1-butan-2-ylpiperidin-4-one

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 11 g of 5-hydrazino-3-methylbenzothiophene hydrochloride and 8.5 g of 1-sec.-butyl-4-piperidone are boiled in 35 ml of isopropanol, and during this procedure isopropanol/HCl are added dropwise. The mixture is then evaporated, the residue is taken up in water and the mixture is rendered alkaline and extracted with methylene chloride. After washing and drying the organic phase, it is evaporated and the residue is recrystallised from cyclohexane. Melting point: 136°-137° C. The mixture is then evaporated extracted with methylene chloride After washing drying the organic phase, it is evaporated the residue is recrystallised from cyclohexane

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 11 g of 5-hydrazino-3-methylbenzothiophene hydrochloride and 8.5 g of 1-sec.-butyl-4-piperidone are boiled in 35 ml of isopropanol, and during this procedure isopropanol/HCl are added dropwise. The mixture is then evaporated, the residue is taken up in water and the mixture is rendered alkaline and extracted with methylene chloride. After washing and drying the organic phase, it is evaporated and the residue is recrystallised from cyclohexane. Melting point: 136°-137° C. The mixture is then evaporated extracted with methylene chloride After washing drying the organic phase, it is evaporated the residue is recrystallised from cyclohexane