1-butylpyrrolidin-2-one

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 15.5 g of n-butylpyrrolidone is heated for 20 hours under reflux in a mixture of 15 g of sodium hydroxide in 100 ml of water. Into the solution (which is cooled to 0° and vigorously agitated) there is slowly introduced (drop by drop) 23.1 g of benzoyl chloride, which is then stirred for a further 5 hours; while further cooling, 5 N hydrochloric acid is added until the reaction mixture becomes acid. The precipitated deposit, which still contains benzoic acid, is separated and recrystallized several times from ligroin to obtain 13.6 g (47% of theory) of N-benzoyl-4-(n-butyl)aminobutyric acid (M.P. 62° to 64°). Into the solution (which is cooled to 0° is then stirred for a further 5 hours The precipitated deposit, which still contains benzoic acid, is separated recrystallized several times from ligroin