(3-chloro-2-methylphenyl)urea

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 3-chloro-2-methylphenylurea (5.0 g, 27.0 mmol), hydrazine hydrate (4.0 g, 80.0 mmol), 4 ml of water and 30 ml of ethanol is heated to reflux for 12 hours. The reaction mixture is then cooled and poured onto ice. A white precipitate forms, which is collected by filtration, washed with water and dried. The resulting solid is dissolved in hot ethanol and conc. HCl is added. The mixture is cooled and the resulting white solid precipitate is collected by filtration, washed with ethanol, and dried under vacuum to give 4-(3-chloro-2-methylphenyl)semicarbazide hydrochloride. is heated to reflux for 12 hours The reaction mixture is then cooled poured onto ice A white precipitate forms, which is collected by filtration washed with water dried The resulting solid is dissolved in hot ethanol conc. HCl is added The mixture is cooled the resulting white solid precipitate is collected by filtration washed with ethanol dried under vacuum

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 3-chloro-2-methylphenylurea (5.0 g, 27.0 mmol), hydrazine hydrate (4.0 g, 80.0 mmol), 4 ml of water and 30 ml of ethanol is heated to reflux for 12 hours. The reaction mixture is then cooled and poured onto ice. A white precipitate forms, which is collected by filtration, washed with water and dried. The resulting solid is dissolved in hot ethanol and conc. HCl is added. The mixture is cooled and the resulting white solid precipitate is collected by filtration, washed with ethanol, and dried under vacuum to give 4-(3-chloro-2-methylphenyl)semicarbazide hydrochloride. is heated to reflux for 12 hours The reaction mixture is then cooled poured onto ice A white precipitate forms, which is collected by filtration washed with water dried The resulting solid is dissolved in hot ethanol conc. HCl is added The mixture is cooled the resulting white solid precipitate is collected by filtration washed with ethanol dried under vacuum