(2R)-2-(4-chlorophenyl)-2-hydroxyacetonitrile

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 1.9 g of (R)-(+)-4-chloromandelonitrile (11 mmol) were dissolved in 18 ml THF and cooled down to 0° C. under nitrogen. 58 ml of a 1M borane-THF complex solution in THF were then added dropwise over 30 min, keeping the temperature between 0-2° C. After addition the reaction mixture was stirred at rt for additional 45 min and then refluxed for 16 h. The reaction mixture is then cooled down to 0° C. and treated between 2 and 5° C. with 13 ml methanol over a period of 35 min. After 1 h refluxing the reaction mixture is concentrated, the residue dissolved in DCM and the amine extracted twice with 1N aqueous HCl. The combined aqueous phases are then treated with concentrated NaOH to adjust the pH to 12, and then extracted twice with DCM. The combined organic phases were then washed with water, dried over magnesium sulfate, filtered and concentrated in vacuo leading to a colorless solid which was dissolved in 100 ml diethylether, treated with 4 ml 2.6N HCl in diethylether, stirred at rt for additional 1 h, filtered and dried under high vacuo, leading to 1.24 g white solid (54%). MS (ISP) 172.1 (M+H)+. between 0-2° C After addition the reaction mixture refluxed for 16 h The reaction mixture is then cooled down to 0° C. After 1 h refluxing the reaction mixture is concentrated the residue dissolved in DCM the amine extracted twice with 1N aqueous HCl The combined aqueous phases are then treated with concentrated NaOH extracted twice with DCM The combined organic phases were then washed with water dried over magnesium sulfate filtered concentrated in vacuo was dissolved in 100 ml diethylether treated with 4 ml 2.6N HCl in diethylether stirred at rt for additional 1 h filtered dried under high vacuo

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 1.9 g of (R)-(+)-4-chloromandelonitrile (11 mmol) were dissolved in 18 ml THF and cooled down to 0° C. under nitrogen. 58 ml of a 1M borane-THF complex solution in THF were then added dropwise over 30 min, keeping the temperature between 0-2° C. After addition the reaction mixture was stirred at rt for additional 45 min and then refluxed for 16 h. The reaction mixture is then cooled down to 0° C. and treated between 2 and 5° C. with 13 ml methanol over a period of 35 min. After 1 h refluxing the reaction mixture is concentrated, the residue dissolved in DCM and the amine extracted twice with 1N aqueous HCl. The combined aqueous phases are then treated with concentrated NaOH to adjust the pH to 12, and then extracted twice with DCM. The combined organic phases were then washed with water, dried over magnesium sulfate, filtered and concentrated in vacuo leading to a colorless solid which was dissolved in 100 ml diethylether, treated with 4 ml 2.6N HCl in diethylether, stirred at rt for additional 1 h, filtered and dried under high vacuo, leading to 1.24 g white solid (54%). MS (ISP) 172.1 (M+H)+. between 0-2° C After addition the reaction mixture refluxed for 16 h The reaction mixture is then cooled down to 0° C. After 1 h refluxing the reaction mixture is concentrated the residue dissolved in DCM the amine extracted twice with 1N aqueous HCl The combined aqueous phases are then treated with concentrated NaOH extracted twice with DCM The combined organic phases were then washed with water dried over magnesium sulfate filtered concentrated in vacuo was dissolved in 100 ml diethylether treated with 4 ml 2.6N HCl in diethylether stirred at rt for additional 1 h filtered dried under high vacuo