cyclopentyl (2R)-2-amino-4-methylpentanoate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: From Intermediate 4F and D-Leucine cyclopentyl ester, LCMS purity 95%, m/z 618 [M+H]+, 1H NMR (300 MHz, DMSO), δ: 10.10 (1H, brs), 9.40-9.10 (2H, m), 8.15 (1H, br s), 7.62-7.52 (1H, m), 7.47-7.31 (2H, m), 7.28-7.12 (1H, m), 7.07 (2H, d, J=10.5 Hz), 5.73 (1H, d, J=9.6 Hz), 5.30-5.20 (1H, m), 4.25-4.00 (3H, m), 3.30-3.00 (2H, m), 2.20-2.00 (2H, m), 1.95-1.80 (2H, m), 1.75-1.55 (10H, m), 1.00-0.90 (6H, m).