No renderable structure data available
C1=CC(=C(C=C1O)C#N)IChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 5-hydroxy-2-iodobenzonitrile |
|---|---|
| IUPAC Name | — |
| CAS Number | 943749-75-5 |
| Database ID | 68696052 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
5-hydroxy-2-iodobenzonitrile (CAS 943749-75-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 68696052
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-ee5b2941289b4d76b2b851292a859a39Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-40fc70de47f744cdbf5cb914e11ba86dConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b137911c936b4e99a9893884c8ed10ceConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-ee5b2941289b4d76b2b851292a859a39Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-40fc70de47f744cdbf5cb914e11ba86dConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b137911c936b4e99a9893884c8ed10ceConditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 5-Hydroxy-2-iodo-benzonitrile (200 mg, 0.82 mmol) and PdCl2(PPh3)2 (20 mg, 0.028 mmol) and 2-furyltributyltin (400 g, 1.12 mmol) in N,N-dimethylformamide (5 mL) is degassed and heated at 100° C. for 15 min. After the mixture cooled to room temperature, an aqueous work up is performed and the product is isolated from chromatography (100 mg, 66%). MS (ESI): 184 (M−1)−1. After the mixture cooled to room temperature the product is isolated from chromatography (100 mg, 66%)
Source ID: ord-71a6bb55f69e48bf953a05f7e80e4ce8Conditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 5-Hydroxy-2-iodo-benzonitrile (200 mg, 0.82 mmol) and PdCl2(PPh3)2 (20 mg, 0.028 mmol) and 2-furyltributyltin (400 g, 1.12 mmol) in N,N-dimethylformamide (5 mL) is degassed and heated at 100° C. for 15 min. After the mixture cooled to room temperature, an aqueous work up is performed and the product is isolated from chromatography (100 mg, 66%). MS (ESI): 184 (M−1)−1. After the mixture cooled to room temperature the product is isolated from chromatography (100 mg, 66%)
Source ID: ord-71a6bb55f69e48bf953a05f7e80e4ce8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 5-Hydroxy-2-iodo-benzonitrile (245 mg, 1 mmol) in THF (3 mL) is added BH3.THF (6 mL, 1 M solution in THF) under N2. The mixture is then allowed to stir at room temperature for 24 hours. The reaction is then quenched with 6N HCl. THF is then removed and the aqueous layer is then neutralized with ammonium hydroxide to pH 9. The mixture is then extracted with CHCl3/MeOH (9:1). The organic layer dried and evaporated and the residue is chromatographed to provide the desired product (80 mg, 32%). The reaction is then quenched with 6N HCl THF is then removed The mixture is then extracted with CHCl3/MeOH (9:1) The organic layer dried evaporated the residue is chromatographed
Source ID: ord-1e0c066abd264201af02fb95b0cb6613Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 5-Hydroxy-2-iodo-benzonitrile (245 mg, 1 mmol) in THF (3 mL) is added BH3.THF (6 mL, 1 M solution in THF) under N2. The mixture is then allowed to stir at room temperature for 24 hours. The reaction is then quenched with 6N HCl. THF is then removed and the aqueous layer is then neutralized with ammonium hydroxide to pH 9. The mixture is then extracted with CHCl3/MeOH (9:1). The organic layer dried and evaporated and the residue is chromatographed to provide the desired product (80 mg, 32%). The reaction is then quenched with 6N HCl THF is then removed The mixture is then extracted with CHCl3/MeOH (9:1) The organic layer dried evaporated the residue is chromatographed
Source ID: ord-1e0c066abd264201af02fb95b0cb6613Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3-Hydroxy-benzonitrile (15 g, 0.126 mol) and iodine monochloride (28 g, 0.172 mol) is heated in acetic acid for 15 hours at 45° C. H2O is added to precipitate the product out. After the precipitate is collected and washed with Na2SO3, the residue is chromatographed with chloroform to get the product (2 g, 7%). to precipitate the product out After the precipitate is collected washed with Na2SO3 the residue is chromatographed with chloroform
Source ID: ord-1733c676e0dd47669e1663e3ec4744ffConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3-Hydroxy-benzonitrile (15 g, 0.126 mol) and iodine monochloride (28 g, 0.172 mol) is heated in acetic acid for 15 hours at 45° C. H2O is added to precipitate the product out. After the precipitate is collected and washed with Na2SO3, the residue is chromatographed with chloroform to get the product (2 g, 7%). MS (ESI): 244.0 (M−1)−1. to precipitate the product out After the precipitate is collected washed with Na2SO3 the residue is chromatographed with chloroform
Source ID: ord-9b9b4aeb07e34314be368335e162467dPubChem References
These sources are listed in the compound's public database record.
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