No renderable structure data available
CCC(C1=CC=CC=C1)ClChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 1-chloropropylbenzene |
|---|---|
| IUPAC Name | — |
| CAS Number | 934-11-2 |
| Database ID | 524241 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
1-chloropropylbenzene (CAS 934-11-2) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 524241
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-fef2b9e01d29402ea4cc3193f4ffd4b9Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-f9eda3f3f3014eb79a2235c709290f1eConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-fef2b9e01d29402ea4cc3193f4ffd4b9Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-fef2b9e01d29402ea4cc3193f4ffd4b9Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under ice cooling, to a solution of 1-phenyl-1-propanol (1.0 g, 7.34 mmol) and N-ethyldiisopropylamine (1.42 g, 11.01 mmol) in dichloromethane (10 ml) was added methanesulfonyl chloride (690 μl, 8.81 mmol), and the mixture was stirred at room temperature for 5 hours. The reaction mixture was diluted with saturated aqueous solution of sodium bicarbonate and extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1) to give 1-chloro-1-phenylpropane (610 mg, 54%) as pale yellow liquid. extracted with ethyl acetate The extract was washed with saturated brine dried over magnesium sulfate, and solvent was distilled off under reduced pressure The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1)
Source ID: ord-63fd590155734261a18701c8a20fd6fbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under ice cooling, to a solution of 1-phenyl-1-propanol (1.0 g, 7.34 mmol) and N-ethyldiisopropylamine (1.42 g, 11.01 mmol) in dichloromethane (10 ml) was added methanesulfonyl chloride (690 μl, 8.81 mmol), and the mixture was stirred at room temperature for 5 hours. The reaction mixture was diluted with saturated aqueous solution of sodium bicarbonate and extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1) to give 1-chloro-1-phenylpropane (610 mg, 54%) as pale yellow liquid. extracted with ethyl acetate The extract was washed with saturated brine dried over magnesium sulfate, and solvent was distilled off under reduced pressure The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1)
Source ID: ord-63fd590155734261a18701c8a20fd6fbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under ice cooling, to a solution of 1-phenyl-1-propanol (1.0 g, 7.34 mmol) and N-ethyldiisopropylamine (1.42 g, 11.01 mmol) in dichloromethane (10 ml) was added methanesulfonyl chloride (690 μl, 8.81 mmol), and the mixture was stirred at room temperature for 5 hours. The reaction mixture was diluted with saturated aqueous solution of sodium bicarbonate and extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1) to give 1-chloro-1-phenylpropane (610 mg, 54%) as pale yellow liquid. extracted with ethyl acetate The extract was washed with saturated brine dried over magnesium sulfate, and solvent was distilled off under reduced pressure The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1)
Source ID: ord-220ff6ae2e7c40578a6107e441c96209Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under ice cooling, to a solution of 1-phenyl-1-propanol (1.0 g, 7.34 mmol) and N-ethyldiisopropylamine (1.42 g, 11.01 mmol) in dichloromethane (10 ml) was added methanesulfonyl chloride (690 μl, 8.81 mmol), and the mixture was stirred at room temperature for 5 hours. The reaction mixture was diluted with saturated aqueous solution of sodium bicarbonate and extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1) to give 1-chloro-1-phenylpropane (610 mg, 54%) as pale yellow liquid. extracted with ethyl acetate The extract was washed with saturated brine dried over magnesium sulfate, and solvent was distilled off under reduced pressure The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1)
Source ID: ord-220ff6ae2e7c40578a6107e441c96209Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was synthesized as a mixture of two diastereomers by general method A from the reaction of (2R)-2-[(2-amino-5-mercapto[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol (30 mg, 100 μmol) with (1-chloropropyl)benzene (15.5 μL, 100 μmol) to give 13 mg (31% yield) as an oil. to give 13 mg (31% yield) as an oil
Source ID: ord-f3b191c93dd14989bc7303a4745678f1Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under ice cooling, to a solution of 1-phenyl-1-propanol (1.0 g, 7.34 mmol) and N-ethyldiisopropylamine (1.42 g, 11.01 mmol) in dichloromethane (10 ml) was added methanesulfonyl chloride (690 μl, 8.81 mmol), and the mixture was stirred at room temperature for 5 hours. The reaction mixture was diluted with saturated aqueous solution of sodium bicarbonate and extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1) to give 1-chloro-1-phenylpropane (610 mg, 54%) as pale yellow liquid. extracted with ethyl acetate The extract was washed with saturated brine dried over magnesium sulfate, and solvent was distilled off under reduced pressure The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1)
Source ID: ord-8d609fad395f47b2b33f5039c244650cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under ice cooling, to a solution of 1-phenyl-1-propanol (1.0 g, 7.34 mmol) and N-ethyldiisopropylamine (1.42 g, 11.01 mmol) in dichloromethane (10 ml) was added methanesulfonyl chloride (690 μl, 8.81 mmol), and the mixture was stirred at room temperature for 5 hours. The reaction mixture was diluted with saturated aqueous solution of sodium bicarbonate and extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1) to give 1-chloro-1-phenylpropane (610 mg, 54%) as pale yellow liquid. extracted with ethyl acetate The extract was washed with saturated brine dried over magnesium sulfate, and solvent was distilled off under reduced pressure The residue was purified by silica gel chromatography (eluent:ethyl acetate/hexane:5/1)
Source ID: ord-8d609fad395f47b2b33f5039c244650cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was synthesized as a mixture of two diastereomers by general method A from the reaction of (2R)-2-[(2-amino-5-mercapto[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol (30 mg, 100 μmol) with (1-chloropropyl)benzene (15.5 μL, 100 μmol) to give 13 mg (31% yield) as an oil. to give 13 mg (31% yield) as an oil
Source ID: ord-a0d16a08c84946b5b53fcdbf122a77cdPubChem References
These sources are listed in the compound's public database record.
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