dodecan-1-amine;hydrochloride

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: n-Dodecylamine hydrochloride (44.4 g, 0.2 mol) and phosphorus oxychloride (91.4 mL, 1.0 mol) were reacted under nitrogen. A clear solution formed within 30 minutes, and the evolution of hydrogen chloride was observed. Heating at reflux was continued for 5 hours. Excess phosphorus oxychloride was removed by distillation in vacuum (40 to 5 torr, 24° to 50° C.) forming N-(n-dodecyl)phosphoramidic dichloride as a viscous liquid. The following spectroscopic data were obtained from the liquid: A clear solution formed within 30 minutes Heating at reflux Excess phosphorus oxychloride was removed by distillation in vacuum (40 to 5 torr, 24° to 50° C.)

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Dodecylamine (85 g, 0.46 mol) was dissolved in methylene chloride (500 mL). The solution was cooled to 0° C., and saturated with anhydrous hydrogen chloride (45 minutes). The white, crystalline solid was separated and dried in vacuum over phosphorus pentoxide, to provide 97.5 g (95.5%) of n-dodecylamine hydrochloride. The white, crystalline solid was separated dried in vacuum over phosphorus pentoxide

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: n-Dodecylamine hydrochloride (44.4 g, 0.2 mol) and phosphorus oxychloride (91.4 mL, 1.0 mol) were reacted under nitrogen. A clear solution formed within 30 minutes, and the evolution of hydrogen chloride was observed. Heating at reflux was continued for 5 hours. Excess phosphorus oxychloride was removed by distillation in vacuum (40 to 5 torr, 24° to 50° C.) forming N-(n-dodecyl)phosphoramidic dichloride as a viscous liquid. The following spectroscopic data were obtained from the liquid: A clear solution formed within 30 minutes Heating at reflux Excess phosphorus oxychloride was removed by distillation in vacuum (40 to 5 torr, 24° to 50° C.)

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Dodecylamine (85 g, 0.46 mol) was dissolved in methylene chloride (500 mL). The solution was cooled to 0° C., and saturated with anhydrous hydrogen chloride (45 minutes). The white, crystalline solid was separated and dried in vacuum over phosphorus pentoxide, to provide 97.5 g (95.5%) of n-dodecylamine hydrochloride. The white, crystalline solid was separated dried in vacuum over phosphorus pentoxide

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: n-Dodecylamine hydrochloride (44.4 g, 0.2 mol) and phosphorus oxychloride (91.4 mL, 1.0 mol) were reacted under nitrogen. A clear solution formed within 30 minutes, and the evolution of hydrogen chloride was observed. Heating at reflux was continued for 5 hours. Excess phosphorus oxychloride was removed by distillation in vacuum (40 to 5 torr, 24° to 50° C.) forming N-(n-dodecyl)phosphoramidic dichloride as a viscous liquid. The following spectroscopic data were obtained from the liquid: A clear solution formed within 30 minutes Heating at reflux Excess phosphorus oxychloride was removed by distillation in vacuum (40 to 5 torr, 24° to 50° C.)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 20 g of N1 -cyano-N3 -benzyl-guanidine and 25.4 g of dodecylamine hydrochloride, 200 ml of mesitylene was added, which was heated and refluxed for 2 hours. After reaction, by the same operation as in Example 1, 23.7 g of the captioned compound was obtained. which was heated refluxed for 2 hours After reaction

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: n-Dodecylamine hydrochloride (44.4 g, 0.2 mol) and phosphorus oxychloride (91.4 mL, 1.0 mol) were reacted under nitrogen. A clear solution formed within 30 minutes, and the evolution of hydrogen chloride was observed. Heating at reflux was continued for 5 hours. Excess phosphorus oxychloride was removed by distillation in vacuum (40 to 5 torr, 24° to 50° C.) forming N-(n-dodecyl)phosphoramidic dichloride as a viscous liquid. The following spectroscopic data were obtained from the liquid: A clear solution formed within 30 minutes Heating at reflux Excess phosphorus oxychloride was removed by distillation in vacuum (40 to 5 torr, 24° to 50° C.)

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Dodecylamine (85 g, 0.46 mol) was dissolved in methylene chloride (500 mL). The solution was cooled to 0° C., and saturated with anhydrous hydrogen chloride (45 minutes). The white, crystalline solid was separated and dried in vacuum over phosphorus pentoxide, to provide 97.5 g (95.5%) of n-dodecylamine hydrochloride. The white, crystalline solid was separated dried in vacuum over phosphorus pentoxide