No renderable structure data available
C1=CC(=C(C=C1Cl)F)CClChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 4-chloro-1-(chloromethyl)-2-fluorobenzene |
|---|---|
| IUPAC Name | — |
| CAS Number | 87417-71-8 |
| Database ID | 14877933 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
4-chloro-1-(chloromethyl)-2-fluorobenzene (CAS 87417-71-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 14877933
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
10 reactions · 10 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7b86a3b9c46c401fba3d9e29b43fc4cfConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-31cca1ddc5474982ac4b9cd88c308aeeConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Then, 18.5 g of 4-chloro-2-fluorobenzyl chloride was dissolved in a mixed solvent consisting of 130 ml of ethanol and 30 ml of water, to which 5.3 g of sodium cyanide was added, and the mixture was heated under reflux for 2 hours. After completion of the reaction, the reaction mixture was allowed to stand for cooling to room temperature, poured into water, and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried, and concentrated. The residue was subjected to silica gel column chromatography, which afforded 15.1 g of 4-chloro-2-fluorophenylacetonitrile. was added the mixture was heated under reflux for 2 hours After completion of the reaction extracted with ethyl acetate The organic layer was washed with saturated sodium chloride solution dried concentrated
Source ID: ord-9c8dcc6cf23b47e990aa25ca7fb5a252Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Then, 16.5 g of 4-chloro-2-fluorobenzylalcohol was dissolved in 150 ml of tetrahydrofuran and 1 ml of pyridine, to which 10 ml of thionyl chloride was added dropwise at 5° C., and the mixture was stirred for 2⅚ hours. After completion of the reaction, the reaction mixture was concentrated, and the precipitated crystals were collected by filtration. The filtrate was subjected to silica gel column chromatography, which afforded 18.5 g of 4-chloro-2-fluorobenzyl chloride. After completion of the reaction the reaction mixture was concentrated the precipitated crystals were collected by filtration
Source ID: ord-c9b36592e60c440fb20983d2b1fa7c29Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7b86a3b9c46c401fba3d9e29b43fc4cfConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-31cca1ddc5474982ac4b9cd88c308aeeConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Then, 18.5 g of 4-chloro-2-fluorobenzyl chloride was dissolved in a mixed solvent consisting of 130 ml of ethanol and 30 ml of water, to which 5.3 g of sodium cyanide was added, and the mixture was heated under reflux for 2 hours. After completion of the reaction, the reaction mixture was allowed to stand for cooling to room temperature, poured into water, and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried, and concentrated. The residue was subjected to silica gel column chromatography, which afforded 15.1 g of 4-chloro-2-fluorophenylacetonitrile. was added the mixture was heated under reflux for 2 hours After completion of the reaction extracted with ethyl acetate The organic layer was washed with saturated sodium chloride solution dried concentrated
Source ID: ord-e3b9ea215b1d4374a45eff06456e2319Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Then, 16.5 g of 4-chloro-2-fluorobenzylalcohol was dissolved in 150 ml of tetrahydrofuran and 1 ml of pyridine, to which 10 ml of thionyl chloride was added dropwise at 5° C., and the mixture was stirred for 2.5/6 hours. After cormpletion of the reaction, the reaction mixture was concentrated, and the precipitated crystals were collected by filtration. The filtrate was subjected to silica gel column chromatography, which afforded 18.5 g of 4-chloro-2-fluorobenzyl chloride. 5/6 hours After cormpletion of the reaction the reaction mixture was concentrated the precipitated crystals were collected by filtration
Source ID: ord-1a1c681692594825969273d9bd98fa08Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Then, 16.5 g of 4-chloro-2-fluorobenzylalcohol was dissolved in 150 ml of tetrahydrofuran and 1 ml of pyridine, to which 10 ml of thionyl chloride was added dropwise at 5° C., and the mixture was stirred for 2⅚ hours. After completion of the reaction, the reaction mixture was concentrated, and the precipitated crystals were collected by filtration. The filtrate was subjected to silica gel column chromatography, which afforded 18.5 g of 4-chloro-2-fluorobenzyl chloride. After completion of the reaction the reaction mixture was concentrated the precipitated crystals were collected by filtration
Source ID: ord-c9b36592e60c440fb20983d2b1fa7c29Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Then, 18.5 g of 4-chloro-2-fluorobenzyl chloride was dissolved in a mixed solvent consisting of 130 ml of ethanol and 30 ml of water, to which 5.3 g of sodium cyanide was added, and the mixture was heated under reflux for 2 hours. After completion of the reaction, the reaction mixture was allowed to stand for cooling to room temperature, poured into water, and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried, and concentrated. The residue was subjected to silica gel column chromatography, which afforded 15.1 g of 4-chloro-2-fluorophenylacetonitrile. was added the mixture was heated under reflux for 2 hours After completion of the reaction extracted with ethyl acetate The organic layer was washed with saturated sodium chloride solution dried concentrated
Source ID: ord-9c8dcc6cf23b47e990aa25ca7fb5a252PubChem References
These sources are listed in the compound's public database record.
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