dichloro-(2-dichlorophosphanylphenyl)phosphane

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 1-Bromo-3,5-bis(2,6-dimethylphenyl)benzene (2.74 g, 7.50 mmol) was added dropwise to magnesium (0.28 g, 11.52 mmol) and THF (10 mL) in an argon atmosphere. After the dropwise addition, the mixture was heated under reflux for 1 hour. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 1-(3,5-bis(2,6-dimethylphenyl))magnesium bromide, and 1,2-bis(dichlorophosphino)benzene (0.28 g, 1.00 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a yellow powder (0.70 g, yield 62%). After the dropwise addition the mixture was heated under reflux for 1 hour filtered After purification

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 3,5-Di-tert-butylbromobenzene (12.50 g, 46.43 mmol) was added dropwise to magnesium (1.70 g, 69.96 mmol) and THF (50 mL) in an argon atmosphere. After the dropwise addition, the mixture was heated under reflux for 1 hour. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 3,5-di-tert-butylphenylmagnesium bromide, and 1,2-bis(dichlorophosphino)benzene (2.00 g, 7.15 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a white powder (4.66 g, yield 73%). After the dropwise addition the mixture was heated under reflux for 1 hour filtered After purification

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 3,5-Di-tert-butylbromobenzene (12.50 g, 46.43 mmol) was added dropwise to magnesium (1.70 g, 69.96 mmol) and THF (50 mL) in an argon atmosphere. After the dropwise addition, the mixture was heated under reflux for 1 hour. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 3,5-di-tert-butylphenylmagnesium bromide, and 1,2-bis(dichlorophosphino)benzene (2.00 g, 7.15 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a white powder (4.66 g, yield 73%). After the dropwise addition the mixture was heated under reflux for 1 hour filtered After purification

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 3,5-Diisopropylbromobenzene (3.04 g, 12.60 mmol) was added dropwise to magnesium (0.48 g, 19.75 mmol) and THF (7 mL) in an argon atmosphere. After the dropwise addition, the mixture was heated under reflux for 1 hour. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 3,5-diisopropylphenylmagnesium bromide, and 1,2-bis(dichlorophosphino)benzene (0.45 g, 1.61 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a yellow oily substance (1.18 g, yield 74%). After the dropwise addition the mixture was heated under reflux for 1 hour filtered After purification

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 3,5-Dimethylbromobenzene (5.54 g, 29.93 mmol) was added dropwise to magnesium (1.07 g, 44.03 mmol) and THF (30 mL) in an argon atmosphere. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 3,5-dimethylphenylmagnesium bromide, and 1,2-bis(dichlorophosphino)benzene (0.95 g, 3.39 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a white powder (1.45 g, yield 76%). filtered After purification

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 3,5-Dimethylbromobenzene (5.54 g, 29.93 mmol) was added dropwise to magnesium (1.07 g, 44.03 mmol) and THF (30 mL) in an argon atmosphere. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 3,5-dimethylphenylmagnesium bromide, and 1,2-bis(dichlorophosphino)benzene (0.95 g, 3.39 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a white powder (1.45 g, yield 76%). filtered After purification

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A THF solution (26.6 mL, 1.03 M, 27.40 mmol) of p-fluorophenylmagnesium bromide was added to a mixture of 1,2-bis(dichlorophosphino)benzene (0.96 g, 3.43 mmol) and THF (20 mL) in an argon atmosphere at −78° C. After warming to room temperature, the mixture was allowed to react overnight at 60° C. The reaction mixture was cooled to ambient temperature, and the solvent was removed under reduced pressure; subsequently, CH2Cl2 (30 mL) was added. 1N aqueous solution of hydrochloric acid (20 mL) was added to the reaction mixture, and the aqueous layer was extracted three times with CH2Cl2. The moisture contained in the combined organic extract was removed with magnesium sulfate, and the extract was filtered. After removing the solvent under reduced pressure, the resulting yellow oily substance was triturated with methanol to give a white powder, and the white powder was washed two times with methanol, giving the title compound as a white powder (1.10 g, yield 62%). to react overnight at 60° C The reaction mixture was cooled to ambient temperature the solvent was removed under reduced pressure subsequently, CH2Cl2 (30 mL) was added 1N aqueous solution of hydrochloric acid (20 mL) was added to the reaction mixture the aqueous layer was extracted three times with CH2Cl2 organic extract was removed with magnesium sulfate the extract was filtered After removing the solvent under reduced pressure the resulting yellow oily substance was triturated with methanol to give a white powder the white powder was washed two times with methanol

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 3,5-Di-tert-butylbromobenzene (12.50 g, 46.43 mmol) was added dropwise to magnesium (1.70 g, 69.96 mmol) and THF (50 mL) in an argon atmosphere. After the dropwise addition, the mixture was heated under reflux for 1 hour. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 3,5-di-tert-butylphenylmagnesium bromide, and 1,2-bis(dichlorophosphino)benzene (2.00 g, 7.15 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a white powder (4.66 g, yield 73%). After the dropwise addition the mixture was heated under reflux for 1 hour filtered After purification

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 3,5-Diisopropylbromobenzene (3.04 g, 12.60 mmol) was added dropwise to magnesium (0.48 g, 19.75 mmol) and THF (7 mL) in an argon atmosphere. After the dropwise addition, the mixture was heated under reflux for 1 hour. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 3,5-diisopropylphenylmagnesium bromide, and 1,2-bis(dichlorophosphino)benzene (0.45 g, 1.61 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a yellow oily substance (1.18 g, yield 74%). After the dropwise addition the mixture was heated under reflux for 1 hour filtered After purification

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 3,5-Dimethylbromobenzene (5.54 g, 29.93 mmol) was added dropwise to magnesium (1.07 g, 44.03 mmol) and THF (30 mL) in an argon atmosphere. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 3,5-dimethylphenylmagnesium bromide, and 1,2-bis(dichlorophosphino)benzene (0.95 g, 3.39 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a white powder (1.45 g, yield 76%). filtered After purification

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A THF solution (26.6 mL, 1.03 M, 27.40 mmol) of p-fluorophenylmagnesium bromide was added to a mixture of 1,2-bis(dichlorophosphino)benzene (0.96 g, 3.43 mmol) and THF (20 mL) in an argon atmosphere at −78° C. After warming to room temperature, the mixture was allowed to react overnight at 60° C. The reaction mixture was cooled to ambient temperature, and the solvent was removed under reduced pressure; subsequently, CH2Cl2 (30 mL) was added. 1N aqueous solution of hydrochloric acid (20 mL) was added to the reaction mixture, and the aqueous layer was extracted three times with CH2Cl2. The moisture contained in the combined organic extract was removed with magnesium sulfate, and the extract was filtered. After removing the solvent under reduced pressure, the resulting yellow oily substance was triturated with methanol to give a white powder, and the white powder was washed two times with methanol, giving the title compound as a white powder (1.10 g, yield 62%). to react overnight at 60° C The reaction mixture was cooled to ambient temperature the solvent was removed under reduced pressure subsequently, CH2Cl2 (30 mL) was added 1N aqueous solution of hydrochloric acid (20 mL) was added to the reaction mixture the aqueous layer was extracted three times with CH2Cl2 organic extract was removed with magnesium sulfate the extract was filtered After removing the solvent under reduced pressure the resulting yellow oily substance was triturated with methanol to give a white powder the white powder was washed two times with methanol

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 1-Bromo-3,5-bis(2,6-dimethylphenyl)benzene (2.74 g, 7.50 mmol) was added dropwise to magnesium (0.28 g, 11.52 mmol) and THF (10 mL) in an argon atmosphere. After the dropwise addition, the mixture was heated under reflux for 1 hour. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 1-(3,5-bis(2,6-dimethylphenyl))magnesium bromide, and 1,2-bis(dichlorophosphino)benzene (0.28 g, 1.00 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a yellow powder (0.70 g, yield 62%). After the dropwise addition the mixture was heated under reflux for 1 hour filtered After purification