[2-(carbamoyloxymethyl)-2-methylpentyl] N-propan-2-ylcarbamate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A second composition to cover the perforated coated cores is prepared as follows: carisoprodol, diclofenac sodium, a diluent and a hinder are placed in a high shear mixer and mix for 5 minutes. The granulation process is initiated by the gradual addition of a granulating solution containing a plasticizer and purified water to the high shear with continuous blending to produce a wet blend. Next, the wet blend is granulated and dried at 40-500 for 20 minutes in a fluid bed to remove the water. Then, the dry granules are screened through a 20 USP mesh screen for size reduction. Next, the screened granules are mixed with a glidant and a lubricant, that have been previously passed through a 60 mesh screen, in a V-Blender during 5 minutes. The granulate is applied over the perforated cores through compression to obtain carisoprodol-diclofenac coated osmotic devices. The coated device has an outer diameter of about 14 mm. is prepared mix for 5 minutes The granulation process is initiated by the gradual addition of a granulating solution containing a plasticizer purified water to the high shear with continuous blending to produce a wet blend dried at 40-500 for 20 minutes in a fluid bed to remove the water Next, the screened granules are mixed with a glidant