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CCOC(=O)CCNC1CC1Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | ethyl 3-(cyclopropylamino)propanoate |
|---|---|
| IUPAC Name | — |
| CAS Number | 76731-85-6 |
| Database ID | 13456042 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
ethyl 3-(cyclopropylamino)propanoate (CAS 76731-85-6) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 13456042
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-a1a319a6c3824d8a9d7effb02489070fConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-4a2a8e0a0de54180a9332cf764823358Conditions: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3 g of sodium carbonate are added to a solution of 3.48 g of 2-chloro-3-ethoxycarbonyl-6,7-difluoroquinoline and 3 g of N-cyclopropyl-N-(β-ethoxycarbonylethyl)amine in 10 cm3 of toluene. The suspension obtained is heated to reflux and then stirred for 15 hours at this temperature. The reaction mixture is then cooled to approximately 20° C. and 30 cm3 of water and 4.5 cm3 of acetic acid are thereafter added. After settling has taken place, the reaction mixture is separated and washed with twice 10 cm3 of water. The organic phase is concentrated to dryness under reduced pressure (20 kPa) at approximately 50° C. 3.3 g of crude 3-ethoxycarbonyl-6,7-difluoro-2-[N-cyclopropyl-N-(β-ethoxycarbonylethyl)amino]quinoline are obtained in the form of an oil, which is used without further purification for the subsequent step. The suspension obtained is heated to reflux the reaction mixture is separated washed with twice 10 cm3 of water The organic phase is concentrated to dryness under reduced pressure (20 kPa) at approximately 50° C
Source ID: ord-b734297800dd43688690a6e9911a857bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 14.0 ml of ethyl 3-bromopropionate are added to a solution of 15.4 ml of cyclopropylamine in 100 ml of toluene and the reaction mixture is heated to 90° for 3 hours. Subsequently, the precipitated salt is filtered and the filtrate is distilled. There are obtained 9.5 g of N-cyclopropyl-β-alanine ethyl ester, Fab-MS: 157 (M+H)+. the reaction mixture is heated to 90° for 3 hours Subsequently, the precipitated salt is filtered the filtrate is distilled
Source ID: ord-dac2e179b3db46c9bcfa592204c73265Conditions: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3 g of sodium carbonate are added to a solution of 3.48 g of 2-chloro-3-ethoxycarbonyl-6,7-difluoroquinoline and 3 g of N-cyclopropyl-N-(β-ethoxycarbonylethyl)amine in 10 cm3 of toluene. The suspension obtained is heated to reflux and then stirred for 15 hours at this temperature. The reaction mixture is then cooled to approximately 20° C. and 30 cm3 of water and 4.5 cm3 of acetic acid are thereafter added. After settling has taken place, the reaction mixture is separated and washed with twice 10 cm3 of water. The organic phase is concentrated to dryness under reduced pressure (20 kPa) at approximately 50° C. 3.3 g of crude 3-ethoxycarbonyl-6,7-difluoro-2-[N-cyclopropyl-N-(β-ethoxycarbonylethyl)amino]quinoline are obtained in the form of an oil, which is used without further purification for the subsequent step. The suspension obtained is heated to reflux the reaction mixture is separated washed with twice 10 cm3 of water The organic phase is concentrated to dryness under reduced pressure (20 kPa) at approximately 50° C
Source ID: ord-b734297800dd43688690a6e9911a857bConditions: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3 g of sodium carbonate are added to a solution of 3.48 g of 2-chloro-3-ethoxycarbonyl-6,7-difluoroquinoline and 3 g of N-cyclopropyl-N-(β-ethoxycarbonylethyl)amine in 10 cm3 of toluene. The suspension obtained is heated to reflux and then stirred for 15 hours at this temperature. The reaction mixture is then cooled to approximately 20° C. and 30 cm3 of water and 4.5 cm3 of acetic acid are thereafter added. After settling has taken place, the reaction mixture is separated and washed with twice 10 cm3 of water. The organic phase is concentrated to dryness under reduced pressure (20 kPa) at approximately 50° C. 3.3 g of crude 3-ethoxycarbonyl-6,7-difluoro-2-[N-cyclopropyl-N-(β-ethoxycarbonylethyl)amino]quinoline are obtained in the form of an oil, which is used without further purification for the subsequent step. The suspension obtained is heated to reflux the reaction mixture is separated washed with twice 10 cm3 of water The organic phase is concentrated to dryness under reduced pressure (20 kPa) at approximately 50° C
Source ID: ord-b734297800dd43688690a6e9911a857bConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-a1a319a6c3824d8a9d7effb02489070fConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-4a2a8e0a0de54180a9332cf764823358Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: B)a) 14.0 ml of ethyl 3-bromopropionate are added to a solution of 15.4 ml of cyclopropylamine in 100 ml of toluene and the reaction mixture is heated to 90° for 3 hours. Subsequently, the precipitated salt is filtered and the filtrate is distilled. There are obtained 9.5 g of N-cyclopropyl-β-alanine ethyl ester, Fab-MS: 157 (M+H)+. the reaction mixture is heated to 90° for 3 hours Subsequently, the precipitated salt is filtered the filtrate is distilled
Source ID: ord-7eda87eb818f44c4be78798302983acaConditions: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3 g of sodium carbonate are added to a solution of 3.48 g of 2-chloro-3-ethoxycarbonyl-6,7-difluoroquinoline, prepared as described in Application Example 1, and 3 g of N-cyclopropyl-N-(b-ethoxycarbonylethyl)amine in 10 cm3 of toluene. The suspension obtained is heated to reflux and then stirred for 15 hours at this temperature. The reaction mixture is then cooled to approximately 20° C. and 30 cm3 of water and 4.5 cm3 of acetic acid are thereafter added. After settling has taken place, the reaction mixture is separated and washed with twice 10 cm3 of water. The organic phase is concentrated to dryness under reduced pressure (20 kPa) at approximately 50° C. 3.3 g of crude 3-ethoxycarbonyl-6,7-difluoro-2-[N-cyclopropyl-N-(b-ethoxycarbonylethyl)amino]quinoline are obtained in the form of an oil, which is used without further purification for the subsequent step. prepared The suspension obtained is heated to reflux the reaction mixture is separated washed with twice 10 cm3 of water The organic phase is concentrated to dryness under reduced pressure (20 kPa) at approximately 50° C
Source ID: ord-b8ce853ca604497faaa22c81f0a662deConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 14.0ml of ethyl 3-bromopropionate are added to a solution of 15.4 ml of cyclopropylamine in 100 ml of toluene and the reaction mixture is heated to 90° for 3 hours. Subsequently, the precipitated salt is filtered and the filtrate is distilled. There are obtained 9.5 g of N-cyclopropyl-β-alanine ethyl ester, Fab-MS: 157 (M+H)+. the reaction mixture is heated to 90° for 3 hours Subsequently, the precipitated salt is filtered the filtrate is distilled
Source ID: ord-4dbfff4dcb564eb2bfca67e3a78b21a9Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 14.0 ml of ethyl 3-bromopropionate are added to a solution of 15.4 ml of cyclopropylamine in 100 ml of toluene and the reaction mixture is heated to 90° for 3 hours. Subsequently, the precipitated salt is filtered and the filtrate is distilled. There are obtained 9.5 g of N-cyclopropyl-β-alanine ethyl ester, Fab-MS: 157 (M+H)+. the reaction mixture is heated to 90° for 3 hours Subsequently, the precipitated salt is filtered the filtrate is distilled
Source ID: ord-0078e503a8624e99a6524d058cd09ef0PubChem References
These sources are listed in the compound's public database record.
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