2-anilino-2-methylpropanamide

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A solution of 2-Methyl-2-phenylamino-propionamide (1 eq) in dry THF (0.2 M) was added dropwise to a stirred ice-cooled suspension of LiAlH4(6 eq) in dry THF (1.2 M) under N2. Upon completion of the addition, the reaction mixture was refluxed for 24 h. The mixture was cooled to 0° C., quenched with water and filtered through Celite. The filtrate was concentrated under reduced pressure and partitioned between water and DCM. The organic phase was separated and washed with brine, then dried (Na2SO4) and concentrated under reduced pressure to yield KK1 as reddish oil which was used as such in the next step. MS (ES) C10H16N2 requires: 164, found: 165 (M+H)+. cooled Upon completion of the addition the reaction mixture was refluxed for 24 h quenched with water filtered through Celite The filtrate was concentrated under reduced pressure partitioned between water and DCM The organic phase was separated washed with brine dried (Na2SO4) concentrated under reduced pressure to yield KK1 as reddish oil which