(2R)-2-chloropropanoyl chloride

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Diethylamine (153 g) is added to a solution, maintained at 20° C., of (R)-2-chloropropionyl chloride (87.7 g) in chloroform (600 cc), in the course of 1 hour. The reaction mixture is washed with distilled water (500 cc), with an aqueous 1N hydrochloric acid solution (3×500 cc) and then with distilled water (500 cc). The organic phase is dried over sodium sulphate, filtered and then concentrated to dryness under reduced pressure (2.7 kPa) at a temperature in the vicinity of 30° C. The residue obtained is distilled under reduced pressure (17 Pa). (R)-N,N-Diethyl-2-chloropropionamide (43 g) in the form of a colourless oil [b.p.17Pa =75°-80° C.; [α]D20 =-43.3° (c=10; CHCl3)] is thereby obtained. The reaction mixture is washed with distilled water (500 cc), with an aqueous 1N hydrochloric acid solution (3×500 cc) The organic phase is dried over sodium sulphate filtered concentrated to dryness under reduced pressure (2.7 kPa) at a temperature in the vicinity of 30° C The residue obtained is distilled under reduced pressure (17 Pa)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Diethylamine (153 g) is added to a solution, maintained at 20° C., of (R)-2-chloropropionyl chloride (87.7 g) in chloroform (600 cc), in the course of 1 hour. The reaction mixture is washed with distilled water (500 cc), with an aqueous 1N hydrochloric acid solution (3×500 cc) and then with distilled water (500 cc). The organic phase is dried over sodium sulphate, filtered and then concentrated to dryness under reduced pressure (2.7 kPa) at a temperature in the vicinity of 30° C. The residue obtained is distilled under reduced pressure (17 Pa). (R)-N,N-Diethyl-2-chloropropionamide (43 g) in the form of a colourless oil [b.p.17Pa =75°-80° C.; [α]D20 =-43.3° (c=10; CHCl3)] is thereby obtained. The reaction mixture is washed with distilled water (500 cc), with an aqueous 1N hydrochloric acid solution (3×500 cc) The organic phase is dried over sodium sulphate filtered concentrated to dryness under reduced pressure (2.7 kPa) at a temperature in the vicinity of 30° C The residue obtained is distilled under reduced pressure (17 Pa)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Diethylamine (153 g) is added to a solution, maintained at 20° C., of (R)-2-chloropropionyl chloride (87.7 g) in chloroform (600 cc), in the course of 1 hour. The reaction mixture is washed with distilled water (500 cc), with an aqueous 1N hydrochloric acid solution (3×500 cc) and then with distilled water (500 cc). The organic phase is dried over sodium sulphate, filtered and then concentrated to dryness under reduced pressure (2.7 kPa) at a temperature in the vicinity of 30° C. The residue obtained is distilled under reduced pressure (17 Pa). (R)-N,N-Diethyl-2-chloropropionamide (43 g) in the form of a colourless oil [b.p.17Pa =75°-80° C.; [α]D20 =-43.3° (c=10; CHCl3)] is thereby obtained. The reaction mixture is washed with distilled water (500 cc), with an aqueous 1N hydrochloric acid solution (3×500 cc) The organic phase is dried over sodium sulphate filtered concentrated to dryness under reduced pressure (2.7 kPa) at a temperature in the vicinity of 30° C The residue obtained is distilled under reduced pressure (17 Pa)