tert-butyl 4-bromo-1H-indole-2-carboxylate

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of 7.3 g 4-Bromo-1H-indole-2-carboxylic acid tert-butyl ester in 100 ml DMF, 6.8 ml NEt3, 276 mg Pd(OAc)2, 128 mg 1,1′-Bis(diphenylphosphino)ferrocene, 12 ml MeOH were added and purged with argon for 15 min. This solution was then purged with carbon monoxide and heated to 70° C. for 4 h. The reaction mixture was concentrated under reduced pressure, the residue dissolved in 200 ml DCM and washed with 100 ml water. The organic layer was dried over MgSO4 and, after removal of the solvent under reduced pressure, the residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1. The fractions containing the product were collected and concentrated under reduced pressure. purged with argon for 15 min This solution was then purged with carbon monoxide The reaction mixture was concentrated under reduced pressure the residue dissolved in 200 ml DCM washed with 100 ml water The organic layer was dried over MgSO4 after removal of the solvent under reduced pressure the residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1 The fractions containing the product were collected concentrated under reduced pressure

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of 7.3 g 4-Bromo-1H-indole-2-carboxylic acid tert-butyl ester in 100 ml DMF, 6.8 ml NEt3, 276 mg Pd(OAc)2, 128 mg 1,1′-Bis(diphenylphosphino)ferrocene, 12 ml MeOH were added and purged with argon for 15 min. This solution was then purged with carbon monoxide and heated to 70° C. for 4 h. The reaction mixture was concentrated under reduced pressure, the residue dissolved in 200 ml DCM and washed with 100 ml water. The organic layer was dried over MgSO4 and, after removal of the solvent under reduced pressure, the residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1. The fractions containing the product were collected and concentrated under reduced pressure. purged with argon for 15 min This solution was then purged with carbon monoxide The reaction mixture was concentrated under reduced pressure the residue dissolved in 200 ml DCM washed with 100 ml water The organic layer was dried over MgSO4 after removal of the solvent under reduced pressure the residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1 The fractions containing the product were collected concentrated under reduced pressure

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of 7.3 g 4-Bromo-1H-indole-2-carboxylic acid tert-butyl ester in 100 ml DMF, 6.8 ml NEt3, 276 mg Pd(OAc)2, 128 mg 1,1′-Bis(diphenylphosphino)ferrocene, 12 ml MeOH were added and purged with argon for 15 min. This solution was then purged with carbon monoxide and heated to 70° C. for 4 h. The reaction mixture was concentrated under reduced pressure, the residue dissolved in 200 ml DCM and washed with 100 ml water. The organic layer was dried over MgSO4 and, after removal of the solvent under reduced pressure, the residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1. The fractions containing the product were collected and concentrated under reduced pressure. Yield: 3.8 g. MS (ESI+): m/e=276. purged with argon for 15 min This solution was then purged with carbon monoxide The reaction mixture was concentrated under reduced pressure the residue dissolved in 200 ml DCM washed with 100 ml water The organic layer was dried over MgSO4 after removal of the solvent under reduced pressure the residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1 The fractions containing the product were collected concentrated under reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7 g 4-Bromo-1H-indole-2-carboxylic acid in 150 ml toluene, 28 ml Di-tert-butoxymethyl-dimethyl-amine were added dropwise at 80° C. The reaction mixture was heated under reflux for additional 12 h. After removal of the solvents under reduced pressure the residue was dissolved in 200 ml DCM and washed with sat. aqueous NaHCO3 solution (2×50 ml). The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1. The fractions containing the product were collected and concentrated under reduced pressure. Yield: 6.5 g . MS (ESI+): m/e=297. The reaction mixture was heated under reflux for additional 12 h After removal of the solvents under reduced pressure the residue was dissolved in 200 ml DCM washed with sat. aqueous NaHCO3 solution (2×50 ml) The organic layer was dried over MgSO4 concentrated under reduced pressure The residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1 The fractions containing the product were collected concentrated under reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7 g 4-Bromo-1H-indole-2-carboxylic acid in 150 ml toluene, 28 ml Di-tert-butoxymethyl-dimethyl-amine were added dropwise at 80° C. The reaction mixture was heated under reflux for additional 12 h. After removal of the solvents under reduced pressure the residue was dissolved in 200 ml DCM and washed with sat. aqueous NaHCO3 solution (2×50 ml). The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1. The fractions containing the product were collected and concentrated under reduced pressure. Yield: 6.5 g . MS (ESI+): m/e=297. The reaction mixture was heated under reflux for additional 12 h After removal of the solvents under reduced pressure the residue was dissolved in 200 ml DCM washed with sat. aqueous NaHCO3 solution (2×50 ml) The organic layer was dried over MgSO4 concentrated under reduced pressure The residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1 The fractions containing the product were collected concentrated under reduced pressure

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of 7.3 g 4-Bromo-1H-indole-2-carboxylic acid tert-butyl ester in 100 ml DMF, 6.8 ml NEt3, 276 mg Pd(OAc)2, 128 mg 1,1′-Bis(diphenylphosphino)ferrocene, 12 ml MeOH were added and purged with argon for 15 min. This solution was then purged with carbon monoxide and heated to 70° C. for 4 h. The reaction mixture was concentrated under reduced pressure, the residue dissolved in 200 ml DCM and washed with 100 ml water. The organic layer was dried over MgSO4 and, after removal of the solvent under reduced pressure, the residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1. The fractions containing the product were collected and concentrated under reduced pressure. purged with argon for 15 min This solution was then purged with carbon monoxide The reaction mixture was concentrated under reduced pressure the residue dissolved in 200 ml DCM washed with 100 ml water The organic layer was dried over MgSO4 after removal of the solvent under reduced pressure the residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1 The fractions containing the product were collected concentrated under reduced pressure

Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of 7.3 g 4-Bromo-1H-indole-2-carboxylic acid tert-butyl ester in 100 ml DMF, 6.8 ml NEt3, 276 mg Pd(OAc)2, 128 mg 1,1′-Bis(diphenylphosphino)ferrocene, 12 ml MeOH were added and purged with argon for 15 min. This solution was then purged with carbon monoxide and heated to 70° C. for 4 h. The reaction mixture was concentrated under reduced pressure, the residue dissolved in 200 ml DCM and washed with 100 ml water. The organic layer was dried over MgSO4 and, after removal of the solvent under reduced pressure, the residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1. The fractions containing the product were collected and concentrated under reduced pressure. Yield: 3.8 g. MS (ESI+): m/e=276. purged with argon for 15 min This solution was then purged with carbon monoxide The reaction mixture was concentrated under reduced pressure the residue dissolved in 200 ml DCM washed with 100 ml water The organic layer was dried over MgSO4 after removal of the solvent under reduced pressure the residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1 The fractions containing the product were collected concentrated under reduced pressure

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To 7 g 4-Bromo-1H-indole-2-carboxylic acid in 150 ml toluene, 28 ml Di-tert-butoxymethyl-dimethyl-amine were added dropwise at 80° C. The reaction mixture was heated under reflux for additional 12 h. After removal of the solvents under reduced pressure the residue was dissolved in 200 ml DCM and washed with sat. aqueous NaHCO3 solution (2×50 ml). The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1. The fractions containing the product were collected and concentrated under reduced pressure. Yield: 6.5 g . MS (ESI+): m/e=297. The reaction mixture was heated under reflux for additional 12 h After removal of the solvents under reduced pressure the residue was dissolved in 200 ml DCM washed with sat. aqueous NaHCO3 solution (2×50 ml) The organic layer was dried over MgSO4 concentrated under reduced pressure The residue was purified by chromatography on silica gel eluting with n-heptane/ethyl acetate 9:1 The fractions containing the product were collected concentrated under reduced pressure