4-chloro-2-fluoro-1-isothiocyanatobenzene

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In 400 ml of chloroform was dissolved 78.9 g of 4-chloro-2-fluorophenyl isothiocyanate, and 68.6 g of 1-morpholino-1-cyclohexene was added dropwise to the solution with stirring over a 10-minute period. After stirring was continued at room temperature for 10 hours, the reaction mixture was concentrated under reduced pressure, and the residue was treated with a small amount of cold ethanol. The resulting crystals were collected by filtration, and there was obtained 127.9 g (yield of 86%) of the subject compound, m.p. 86°-88° C. was added dropwise to the solution After stirring the reaction mixture was concentrated under reduced pressure the residue was treated with a small amount of cold ethanol The resulting crystals were collected by filtration

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In 400 ml of chloroform was dissolved 78.9 g of 4-chloro-2-fluorophenyl isothiocyanate, and 68.6 g of 1-morpholino-1-cyclohexene was added dropwise to the solution with stirring over a 10-minute period. After stirring was continued at room temperature for 10 hours, the reaction mixture was concentrated under reduced pressure, and the residue was treated with a small amount of cold ethanol. The resulting crystals were collected by filtration, and there was obtained 127.9 g (yield of 86%) of the subject compound, m.p. 86°-88° C. was added dropwise to the solution After stirring the reaction mixture was concentrated under reduced pressure the residue was treated with a small amount of cold ethanol The resulting crystals were collected by filtration