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COC(=O)C1=CC(=C(C=C1O)O)ClChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | methyl 5-chloro-2,4-dihydroxybenzoate |
|---|---|
| IUPAC Name | — |
| CAS Number | 67828-69-7 |
| Database ID | 105751 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
methyl 5-chloro-2,4-dihydroxybenzoate (CAS 67828-69-7) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 105751
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-21bfc3a953054d73b2607fa5656705e2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 1-(chloromethyl)-4-methoxybenzene (1.53 g, 9.8 mmol), methyl 5-chloro-2,4-dihydroxybenzoate (1.98 g, 9.8 mmol) and potassiumcarbonate (1.35 g, 9.8 mmol) in acetone (15 mL) was stirred at reflux overnight. The mixture was filtered, solvent was removed in vacuo, the residue was dissolved in ethyl acetate and was washed with brine two times. The organic layer was dried over sodium sulphate, solvent was removed in vacuo and the residue was purified by recrystillaziation from methanol. (1.46 g, 46%) of the title compound was obtained. at reflux overnight The mixture was filtered solvent was removed in vacuo the residue was dissolved in ethyl acetate was washed with brine two times The organic layer was dried over sodium sulphate, solvent was removed in vacuo the residue was purified by recrystillaziation from methanol
Source ID: ord-e550dedff9c94e0994e39ea2f1730c81Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 1-(chloromethyl)-4-methoxybenzene (1.53 g, 9.8 mmol), methyl 5-chloro-2,4-dihydroxybenzoate (1.98 g, 9.8 mmol) and potassiumcarbonate (1.35 g, 9.8 mmol) in acetone (15 mL) was stirred at reflux overnight. The mixture was filtered, solvent was removed in vacuo, the residue was dissolved in ethyl acetate and was washed with brine two times. The organic layer was dried over sodium sulphate, solvent was removed in vacuo and the residue was purified by recrystillaziation from methanol. (1.46 g, 46%) of the title compound was obtained. at reflux overnight The mixture was filtered solvent was removed in vacuo the residue was dissolved in ethyl acetate was washed with brine two times The organic layer was dried over sodium sulphate, solvent was removed in vacuo the residue was purified by recrystillaziation from methanol
Source ID: ord-e550dedff9c94e0994e39ea2f1730c81Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of methyl 5-chloro-2,4-dihydroxybenzoate (0.41 g, 2 mmol) in acetone were added 1-(chloromethyl)-4-methoxybenzene (0.32 g, 2 mmol) and K2CO3 (0.28 g, 2 mmol). The reaction mixture was heated with reflux for 3 days, than cooled to room temperature. The inorganic material was removed by filtration. The solvent was distilled in vacuo, and the residue was recrystallized from methanol to afford white solid (0.37 g, 60%). The reaction mixture was heated with reflux for 3 days The inorganic material was removed by filtration The solvent was distilled in vacuo the residue was recrystallized from methanol
Source ID: ord-97178c0cb3eb4b458f40f9f00d21e1ccConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of methyl 5-chloro-2,4-dihydroxybenzoate (0.41 g, 2 mmol) in acetone were added 1-(chloromethyl)-4-methoxybenzene (0.32 g, 2 mmol) and K2CO3 (0.28 g, 2 mmol). The reaction mixture was heated with reflux for 3 days, than cooled to room temperature. The inorganic material was removed by filtration. The solvent was distilled in vacuo, and the residue was recrystallized from methanol to afford white solid (0.37 g, 60%). The reaction mixture was heated with reflux for 3 days The inorganic material was removed by filtration The solvent was distilled in vacuo the residue was recrystallized from methanol
Source ID: ord-97178c0cb3eb4b458f40f9f00d21e1ccConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 1-(chloromethyl)-4-methoxybenzene (1.53 g, 9.8 mmol), methyl 5-chloro-2,4-dihydroxybenzoate (1.98 g, 9.8 mmol) and potassiumcarbonate (1.35 g, 9.8 mmol) in acetone (15 mL) was stirred at reflux overnight. The mixture was filtered, solvent was removed in vacuo, the residue was dissolved in ethyl acetate and was washed with brine two times. The organic layer was dried over sodium sulphate, solvent was removed in vacuo and the residue was purified by recrystillaziation from methanol. (1.46 g, 46%) of the title compound was obtained. at reflux overnight The mixture was filtered solvent was removed in vacuo the residue was dissolved in ethyl acetate was washed with brine two times The organic layer was dried over sodium sulphate, solvent was removed in vacuo the residue was purified by recrystillaziation from methanol
Source ID: ord-e550dedff9c94e0994e39ea2f1730c81Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of methyl 5-chloro-2,4-dihydroxybenzoate (0.41 g, 2 mmol) in acetone were added 1-(chloromethyl)-4-methoxybenzene (0.32 g, 2 mmol) and K2CO3 (0.28 g, 2 mmol). The reaction mixture was heated with reflux for 3 days, than cooled to room temperature. The inorganic material was removed by filtration. The solvent was distilled in vacuo, and the residue was recrystallized from methanol to afford white solid (0.37 g, 60%). The reaction mixture was heated with reflux for 3 days The inorganic material was removed by filtration The solvent was distilled in vacuo the residue was recrystallized from methanol
Source ID: ord-97178c0cb3eb4b458f40f9f00d21e1ccConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of methyl 5-chloro-2,4-dihydroxybenzoate (0.41 g, 2 mmol) in acetone were added 1-(chloromethyl)-4-methoxybenzene (0.32 g, 2 mmol) and K2CO3 (0.28 g, 2 mmol). The reaction mixture was heated with reflux for 3 days, than cooled to room temperature. The inorganic material was removed by filtration. The solvent was distilled in vacuo, and the residue was recrystallized from methanol to afford white solid (0.37 g, 60%). The reaction mixture was heated with reflux for 3 days The inorganic material was removed by filtration The solvent was distilled in vacuo the residue was recrystallized from methanol
Source ID: ord-97178c0cb3eb4b458f40f9f00d21e1ccConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-21bfc3a953054d73b2607fa5656705e2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of methyl 5-chloro-2,4-dihydroxybenzoate (0.41 g, 2 mmol) in acetone were added 1-(chloromethyl)-4-methoxybenzene (0.32 g, 2 mmol) and K2CO3 (0.28 g, 2 mmol). The reaction mixture was heated with reflux for 3 days, than cooled to room temperature. The inorganic material was removed by filtration. The solvent was distilled in vacuo, and the residue was recrystallized from methanol to afford white solid (0.37 g, 60%). The reaction mixture was heated with reflux for 3 days The inorganic material was removed by filtration The solvent was distilled in vacuo the residue was recrystallized from methanol
Source ID: ord-9a5363e929eb4ba185fd0d7516fbd13cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 1-(chloromethyl)-4-methoxybenzene (1.53 g, 9.8 mmol), methyl 5-chloro-2,4-dihydroxybenzoate (1.98 g, 9.8 mmol) and potassiumcarbonate (1.35 g, 9.8 mmol) in acetone (15 mL) was stirred at reflux overnight. The mixture was filtered, solvent was removed in vacuo, the residue was dissolved in ethyl acetate and was washed with brine two times. The organic layer was dried over sodium sulphate, solvent was removed in vacuo and the residue was purified by recrystillaziation from methanol. (1.46 g, 46%) of the title compound was obtained. at reflux overnight The mixture was filtered solvent was removed in vacuo the residue was dissolved in ethyl acetate was washed with brine two times The organic layer was dried over sodium sulphate, solvent was removed in vacuo the residue was purified by recrystillaziation from methanol
Source ID: ord-e550dedff9c94e0994e39ea2f1730c81Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of methyl 5-chloro-2,4-dihydroxybenzoate (0.41 g, 2 mmol) in acetone were added 1-(chloromethyl)-4-methoxybenzene (0.32 g, 2 mmol) and K2CO3 (0.28 g, 2 mmol). The reaction mixture was heated with reflux for 3 days, than cooled to room temperature. The inorganic material was removed by filtration. The solvent was distilled in vacuo, and the residue was recrystallized from methanol to afford white solid (0.37 g, 60%). The reaction mixture was heated with reflux for 3 days The inorganic material was removed by filtration The solvent was distilled in vacuo the residue was recrystallized from methanol
Source ID: ord-97178c0cb3eb4b458f40f9f00d21e1ccPubChem References
These sources are listed in the compound's public database record.
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