No renderable structure data available
CCNC(=O)OCC1=CC=CC=C1Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | benzyl N-ethylcarbamate |
|---|---|
| IUPAC Name | — |
| CAS Number | 65935-09-3 |
| Database ID | 12384304 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
benzyl N-ethylcarbamate (CAS 65935-09-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 12384304
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-054df3138b85424abf99a649aafabafaConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-9cc641a72d8a451d951297ddebc8e6a0Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7180d2fb18374637a43b690e2d7df675Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To 2-(4-bromo-3-bromomethyl-phenyl)-propan-2-ol (0.255 g, 0.83 mmol) and ethyl-carbamic acid benzyl ester (0.446 g, 2.49 mmol) in DMF (15 mL) was added sodium hydride (60% in mineral oil; 0.103 g, 2.57 mmol), and the reaction was stirred for 30 minutes. The mixture was quenched with H2O and worked-up. The residue was purified by silica gel chromatography (0-40% EtOAc in hexanes) to give the title compound. The mixture was quenched with H2O The residue was purified by silica gel chromatography (0-40% EtOAc in hexanes)
Source ID: ord-1f72b05d210b4aaea4e4f6e4d74f951cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To 2-(4-bromo-3-bromomethyl-phenyl)-propan-2-ol (0.255 g, 0.83 mmol) and ethyl-carbamic acid benzyl ester (0.446 g, 2.49 mmol) in DMF (15 mL) was added sodium hydride (60% in mineral oil; 0.103 g, 2.57 mmol), and the reaction was stirred for 30 minutes. The mixture was quenched with H2O and worked-up. The residue was purified by silica gel chromatography (0-40% EtOAc in hexanes) to give the title compound. The mixture was quenched with H2O The residue was purified by silica gel chromatography (0-40% EtOAc in hexanes)
Source ID: ord-1f72b05d210b4aaea4e4f6e4d74f951cConditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Bromo-3-bromomethyl-benzoic acid ethyl ester (2.95 g, 9.2 mmol) and ethyl-carbamic acid benzyl ester (3.30 g, 18.4 mmol) were combined in DMF (100 mL) and cooled to 0° C. Sodium hydride (60% in mineral oil; 0.772 g, 19.3 mmol) was added slowly, and the reaction was stirred at room temperature for 10 minutes. The mixture was quenched with H2O and 1N aqueous HCl (20 mL), and then extracted with 1:1 EtOAc:hexanes three times. The organic layer was washed with brine, and then dried and concentrated. The residue was purified by silica gel chromatography (0-100% EtOAc in hexanes) to give the title compound, as well as the hydrolyzed product, which was combined with the product from the next step. The mixture was quenched with H2O and 1N aqueous HCl (20 mL) extracted with 1:1 EtOAc The organic layer was washed with brine dried concentrated The residue was purified by silica gel chromatography (0-100% EtOAc in hexanes)
Source ID: ord-cd3398cff1db42aaa277dc4db761a6b4Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Ethylamine (1.3 mL, 20.0 mmol) and diisopropylethylamine (7 mL, 40.0 mmol) were combined in CH2Cl2 (200 mL) and cooled to 0° C. Benzyl chloroformate (2.86 mL, 20.0 mmol) was added dropwise, and the reaction was stirred at 0° C. for 30 minutes. Once no starting material was seen by analytical tlc, the mixture was warmed to room temperature and washed with H2O, 0.1N aqueous HCl, and H2O, and then dried and concentrated to give the title compound. the mixture was warmed to room temperature washed with H2O, 0.1N aqueous HCl, and H2O dried concentrated
Source ID: ord-e512d783c92f401387eeea7e85b6f925Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 4-Bromo-3-bromomethyl-benzoic acid ethyl ester (2.95 g, 9.2 mmol) and ethyl-carbamic acid benzyl ester (3.30 g, 18.4 mmol) were combined in DMF (100 mL) and cooled to 0° C. Sodium hydride (60% in mineral oil; 0.772 g, 19.3 mmol) was added slowly, and the reaction was stirred at room temperature for 10 minutes. The mixture was quenched with H2O and 1N aqueous HCl (20 mL), and then extracted with 1:1 EtOAc:hexanes three times. The organic layer was washed with brine, and then dried and concentrated. The residue was purified by silica gel chromatography (0-100% EtOAc in hexanes) to give 3-[(N-benzyloxycarbonyl-N-ethyl-amino)-methyl]-4-bromo-benzoic acid ethyl ester, as well as the hydrolyzed product, which was combined with the product from the next step. The mixture was quenched with H2O and 1N aqueous HCl (20 mL) extracted with 1:1 EtOAc The organic layer was washed with brine dried concentrated The residue was purified by silica gel chromatography (0-100% EtOAc in hexanes)
Source ID: ord-f0395defb27541b986adc55ea70f066dConditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Ethylamine (1.3 mL, 20.0 mmol) and diisopropylethylamine (7 mL, 40.0 mmol) were combined in CH2Cl2 (200 mL) and cooled to 0° C. Benzyl chloroformate (2.86 mL, 20.0 mmol) was added dropwise, and the reaction was stirred at 0° C. for 30 minutes. The mixture was warmed to room temperature and washed with H2O, 0.1N aqueous HCl, and H2O, and then dried and concentrated to give ethyl-carbamic acid benzyl ester. The mixture was warmed to room temperature washed with H2O, 0.1N aqueous HCl, and H2O dried concentrated
Source ID: ord-f10d517132084b74942779715f223f2fConditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Ethylamine (1.3 mL, 20.0 mmol) and diisopropylethylamine (7 mL, 40.0 mmol) were combined in CH2Cl2 (200 mL) and cooled to 0° C. Benzyl chloroformate (2.86 mL, 20.0 mmol) was added dropwise, and the reaction was stirred at 0° C. for 30 minutes. The mixture was warmed to room temperature and washed with H2O, 0.1N aqueous HCl, and H2O, and then dried and concentrated to give ethyl-carbamic acid benzyl ester. The mixture was warmed to room temperature washed with H2O, 0.1N aqueous HCl, and H2O dried concentrated
Source ID: ord-f10d517132084b74942779715f223f2fConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-054df3138b85424abf99a649aafabafaConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-9cc641a72d8a451d951297ddebc8e6a0PubChem References
These sources are listed in the compound's public database record.
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