3,6-dichloro-2-methyl-1-benzothiophene 1,1-dioxide

Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 3.75 g 3,6-dichloro-2-methyl-benzo[b]-thiophene-1,1-dioxide and 35 ml piperidine is stirred for 4 hours at 80° C., water is subsequently added and it is extracted with ethyl acetate. The extract is concentrated by evaporation and it is ground with ethyl acetate. 1.6 g of the title compound (36% of the theoretical yield) of melting point 154°-156° C. is isolated. it is extracted with ethyl acetate The extract is concentrated by evaporation and it

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 37.3 g (0.15 mol) 3,6-dichloro-2-methylbenzo[b]thiophene-1,1-dioxide, 200 ml methanol and 45 ml diethylamine is heated for 4 hours to reflux. Afterwards it is concentrated by evaporation, taken up in ethyl acetate, washed with water, dried, concentrated and chromatographed on silica gel (eluting agent ethyl acetate/isohexane 1:1). 29.5 g of the title compound (62% of the theoretical yield) having a melting point of 58°-59° C. is isolated. is heated for 4 hours to reflux Afterwards it is concentrated by evaporation washed with water dried concentrated chromatographed on silica gel (eluting agent ethyl acetate/isohexane 1:1)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 37.3 g (0.15 mol) 3,6-dichloro-2-methylbenzo[b]thiophene-1,1-dioxide, 200 ml methanol and 45 ml diethylamine is heated for 4 hours to reflux. Afterwards it is concentrated by evaporation, taken up in ethyl acetate, washed with water, dried, concentrated and chromatographed on silica gel (eluting agent ethyl acetate/isohexane 1:1). 29.5 g of the title compound (62% of the theoretical yield) having a melting point of 58°-59° C. is isolated. is heated for 4 hours to reflux Afterwards it is concentrated by evaporation washed with water dried concentrated chromatographed on silica gel (eluting agent ethyl acetate/isohexane 1:1)

Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 3.75 g 3,6-dichloro-2-methyl-benzo[b]-thiophene-1,1-dioxide and 35 ml piperidine is stirred for 4 hours at 80° C., water is subsequently added and it is extracted with ethyl acetate. The extract is concentrated by evaporation and it is ground with ethyl acetate. 1.6 g of the title compound (36% of the theoretical yield) of melting point 154°-156° C. is isolated. it is extracted with ethyl acetate The extract is concentrated by evaporation and it

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 37.3 g (0.15 mol) 3,6-dichloro-2-methylbenzo[b]thiophene-1,1-dioxide, 200 ml methanol and 45 ml diethylamine is heated for 4 hours to reflux. Afterwards it is concentrated by evaporation, taken up in ethyl acetate, washed with water, dried, concentrated and chromatographed on silica gel (eluting agent ethyl acetate/isohexane 1:1). 29.5 g of the title compound (62% of the theoretical yield) having a melting point of 58°-59° C. is isolated. is heated for 4 hours to reflux Afterwards it is concentrated by evaporation washed with water dried concentrated chromatographed on silica gel (eluting agent ethyl acetate/isohexane 1:1)