2-[4-(2-aminoethyl)piperazin-1-yl]ethanamine

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Beginning with N,N-bis(3 -aminopropyl)methylamine, 1-{3-[methyl(3-aminopropyl)amino]propyl}amino-7-fluoro-4-nitro-10H-acridin-9-one (compound 2c) is prepared by the above method. By the same method, but beginning with 1,4-bis(2-aminoethyl)piperazine, it is possible to prepare 1-{2-[4-(2-aminoethyl)piperazin-1-yl]ethyl}amino-7-fluoro-4-nitro-10H-acridin-9-one. is prepared by the above method

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Beginning with N,N-bis(3 -aminopropyl)methylamine, 1-{3-[methyl(3-aminopropyl)amino]propyl}amino-7-fluoro-4-nitro-10H-acridin-9-one (compound 2c) is prepared by the above method. By the same method, but beginning with 1,4-bis(2-aminoethyl)piperazine, it is possible to prepare 1-{2-[4-(2-aminoethyl)piperazin-1-yl]ethyl}amino-7-fluoro-4-nitro-10H-acridin-9-one. is prepared by the above method

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Beginning with N,N-bis(3 -aminopropyl)methylamine, 1-{3-[methyl(3-aminopropyl)amino]propyl}amino-7-fluoro-4-nitro-10H-acridin-9-one (compound 2c) is prepared by the above method. By the same method, but beginning with 1,4-bis(2-aminoethyl)piperazine, it is possible to prepare 1-{2-[4-(2-aminoethyl)piperazin-1-yl]ethyl}amino-7-fluoro-4-nitro-10H-acridin-9-one. is prepared by the above method