(2S)-N,N-diethyl-2-hydroxy-2-phenylacetamide

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To a solution of the hydroxy-phenyl-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester (0.70 g, 2.8 mmol) in THF/H2O (10 mL, 1:1) was added diethylamine (25% in H2O, 0.58 mL, 5.6 mmol). After stirring for 16 h, the reaction solvent was evaporated under reduced pressure. The resulting residue was diluted with H2O and extracted with EtOAc (3×50 mL). The organic extracts were combined, dried (Na2SO4), and the solvent was evaporated under reduced pressure to yield the title compound. the reaction solvent was evaporated under reduced pressure The resulting residue was diluted with H2O extracted with EtOAc (3×50 mL) dried (Na2SO4) the solvent was evaporated under reduced pressure