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C1=CC=C(C=C1)CC(=S)NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-phenylethanethioamide |
|---|---|
| IUPAC Name | — |
| CAS Number | 645-54-5 |
| Database ID | 731368 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-phenylethanethioamide (CAS 645-54-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 731368
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-ddd3ac7d1f3547d6909d9a96bfa44402Conditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl[(6-bromo-5,6,7,8-tetrahydro-5-oxo-1-naphthalenyl)oxy]acetate (2.16 g, 6.61 mmol) and phenylthioacetamide (1.00 g, 6.61 mmol) in a mixture of ethanol (25 mL) and N,N-dimethylformamide (5 mL) was stirred at 60° C. for 14 hours and, then, refluxed for 2 hours. After cooling, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride solution, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (hexane-ethyl acetate=1:5) to provide ethyl[(2-benzyl-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetate (540 mg). To a solution of this compound (0.54 g, 1.42 mmol) in a mixture of tetrahydrofuran (16 mL) and methanol (4 mL) was added 1N-hydrochloric acid followed by extraction with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride solution, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to provide 320 mg of the title compound. Yield 14%. refluxed for 2 hours After cooling extracted with ethyl acetate The organic layer was washed with water and saturated aqueous sodium chloride solution dried over MgSO4 filtered concentrated under reduced pressure
Source ID: ord-54ded62641cf4f2f8f7ae1f391d89c50Conditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl[(6-bromo-5,6,7,8-tetrahydro-5-oxo-1-naphthalenyl)oxy]acetate (2.16 g, 6.61 mmol) and phenylthioacetamide (1.00 g, 6.61 mmol) in a mixture of ethanol (25 mL) and N,N-dimethylformamide (5 mL) was stirred at 60° C. for 14 hours and, then, refluxed for 2 hours. After cooling, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride solution, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (hexane-ethyl acetate=1:5) to provide ethyl[(2-benzyl-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetate (540 mg). To a solution of this compound (0.54 g, 1.42 mmol) in a mixture of tetrahydrofuran (16 mL) and methanol (4 mL) was added 1N-hydrochloric acid followed by extraction with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride solution, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to provide 320 mg of the title compound. Yield 14%. refluxed for 2 hours After cooling extracted with ethyl acetate The organic layer was washed with water and saturated aqueous sodium chloride solution dried over MgSO4 filtered concentrated under reduced pressure
Source ID: ord-54ded62641cf4f2f8f7ae1f391d89c50Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of phenylacetonitrile (10.0 g, 85.4 mmol) and diethyl dithiophosphate (17.5 g, 93.9 mmol) in 4N-HCl/ethyl acetate (400 mL) was stirred at room temperature for 16 hours. This reaction mixture was washed with water and saturated aqueous sodium hydrogen carbonate solution, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was crystallized from ethanol to provide 7.1 g of the title compound. Yield 55%. This reaction mixture was washed with water and saturated aqueous sodium hydrogen carbonate solution dried over MgSO4 filtered concentrated under reduced pressure The residue was crystallized from ethanol
Source ID: ord-b95e9b3ac9114e76baa3b07b56de8fcdConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound was prepared as described in Example 806A, substituting 2-bromo-1-(5-nitrothiophen-2-yl)ethanone for 2-bromo-1-(4-nitrophenyl)ethanone and 2-(2-chlorophenyl)ethanethioamide for 2-phenylethanethioamide.
Source ID: ord-86da2cf31f0d447f987e1ce787aea6f5Conditions: temp:140.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 2-Bromo-1-(4-nitrophenyl)ethanone (0.5 g, 2.049 mmol) and 2-phenylethanethioamide (0.310 g, 2.049 mmol) were combined in ethanol (10 ml) in a 20 mL microwave reaction vessel and heated at 140° C. for 15 minutes. The solution was transferred to a 250 mL round bottom flask where it immediately solidified. The material was diluted with an additional ethanol (10 ml) and was heated at reflux with stirring until the solids were dissolved. Water (5.0 ml, 278 mmol), and hydrochloric acid (1 ml, 12.00 mmol) were added. Iron (0.625 g, 11.19 mmol) was added and the mixture was heated at reflux for 2 hours. The mixture was allowed to cool and 5 mL NH4OH was added. The material was filtered through a pad of diatomaceous earth and the pad was washed with 50 mL of ethyl acetate. The filtrate was washed with 100 mL of water and the aqueous phase was extracted with an additional 50 mL of ethyl acetate. The combined organic fractions were dried over sodium sulfate, filtered, and the solvent was removed under reduced pressure. The material was re-dissolved in 50 mL of ethyl acetate and filtered through a ¼-inch pad of silica gel. The pad was washed with an additional 50 mL of ethyl acetate and the combined filtrate was concentrated to provide the title compound. The solution was transferred to a 250 mL round bottom flask was heated at reflux were dissolved the mixture was heated at reflux for 2 hours to cool The material was filtered through a pad of diatomaceous earth the pad was washed with 50 mL of ethyl acetate The filtrate was washed with 100 mL of water the aqueous phase was extracted with an additional 50 mL of ethyl acetate The combined organic fractions were dried over sodium sulfate filtered the solvent was removed under reduced pressure The material was re-dissolved in 50 mL of ethyl acetate filtered through a ¼-inch pad of silica gel The pad was washed with an additional 50 mL of ethyl acetate the combined filtrate was concentrated
Source ID: ord-3f4ebb7ed1c14c9792b833efd0771e13Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 40 g of ethyl bromopyruvate were progressively added to a mixture of 30.2 g of phenylthioacetamide, 120 ml of ethanol and 20 ml of pyridine and the mixture was refluxed for 16 hours. The mixture was evaporated to dryness under reduced pressure and the residue was added to a water-ether mixture. The mixture was stirred and the decanted aqueous phase was extracted with ether. The combined organic phases were evaporated to dryness and the residue was chromatographed over silica gel. Elution with a 7-3 hexane-ethyl acetate mixture yielded 22.5 g of ethyl 2-benzyl-thiazole-4-carboxylate melting at 78°-79° C. the mixture was refluxed for 16 hours The mixture was evaporated to dryness under reduced pressure the residue was added to a water-ether mixture the decanted aqueous phase was extracted with ether The combined organic phases were evaporated to dryness the residue was chromatographed over silica gel Elution with a 7-3 hexane-ethyl acetate mixture
Source ID: ord-6e2c49df7d8d4595b97744a178310842Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 40 g of ethyl bromopyruvate were progressively added to a mixture of 30.2 g of phenylthioacetamide, 120 ml of ethanol and 20 ml of pyridine and the mixture was refluxed for 16 hours. The mixture was evaporated to dryness under reduced pressure and the residue was added to a water-ether mixture. The mixture was stirred and the decanted aqueous phase was extracted with ether. The combined organic phases were evaporated to dryness and the residue was chromatographed over silica gel. Elution with a 7-3 hexane-ethyl acetate mixture yielded 22.5 g of ethyl 2-benzyl-thiazole-4-carboxylate melting at 78°-79° C. the mixture was refluxed for 16 hours The mixture was evaporated to dryness under reduced pressure the residue was added to a water-ether mixture the decanted aqueous phase was extracted with ether The combined organic phases were evaporated to dryness the residue was chromatographed over silica gel Elution with a 7-3 hexane-ethyl acetate mixture
Source ID: ord-6e2c49df7d8d4595b97744a178310842Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 40 g of allyl bromopyruvate were progressively added to a mixture of 30.2 gof phenylthioacetamide, 120 ml of ethanol and 20 ml of pyridine and the mixture was refluxed for 16 hours. The mixture was evaporated to dryness under reduced pressure and the residue was added to a water-ether mixture.The mixture was stirred and the decanted aqueous phase was extracte with ether. The combined organic phases were evaporated to dryness and the residue was chromatographed over silica gel. Elution with a 7-3 hexane-ethyl acetate mixture yielded 22.5 g of ethyl 2-benzyl-thiazole-4-carboxylate melting at 78°-79° C. the mixture was refluxed for 16 hours The mixture was evaporated to dryness under reduced pressure the residue was added to a water-ether mixture.The mixture The combined organic phases were evaporated to dryness the residue was chromatographed over silica gel Elution with a 7-3 hexane-ethyl acetate mixture
Source ID: ord-7945e9405fb0499ab04f566604a604d7Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-ddd3ac7d1f3547d6909d9a96bfa44402Conditions: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of ethyl [(6-bromo-5,6,7,8-tetrahydro-5-oxo-1-naphthalenyl)oxy]acetate (2.16 g, 6.61 mmol) and phenylthioacetamide (1.00 g, 6.61 mmol) in a mixture of ethanol (25 mL) and N,N-dimethylformamide (5 mL) was stirred at 60° C. for 14 hours and, then, refluxed for 2 hours. After cooling, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride solution, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (hexane-ethyl acetate=1:5) to provide ethyl [(2-benzyl-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetate (540 mg). To a solution of this compound (0.54 g, 1.42 mmol) in a mixture of tetrahydrofuran (16 mL) and methanol (4 mL) was added 1N-hydrochloric acid followed by extraction with ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride solution, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to provide 320 mg of the title compound Yield 14%. refluxed for 2 hours After cooling extracted with ethyl acetate The organic layer was washed with water and saturated aqueous sodium chloride solution dried over MgSO4 filtered concentrated under reduced pressure
Source ID: ord-5555165bbe554d3c9c352aa18be5a724Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of amino acid methyl ester VI and imidazole in DMF, is added phenylthioacetic acid followed by diisopropylcarbodiimide at room temperature. The reaction mixture is stirred for 12 hours. After filtration on silica gel pad, the filtrate is poured into water and EtOAc. The organic layer is washed twice with water, dried over Na2SO4, and concentrated to afford α-phenylthioacetamide VII. After filtration on silica gel pad the filtrate is poured into water and EtOAc The organic layer is washed twice with water dried over Na2SO4 concentrated
Source ID: ord-3a41d5f021714c87a95f31b87e2b23f6PubChem References
These sources are listed in the compound's public database record.
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