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CC(=O)NC1=CC(=CC=C1)BrChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | N-(3-bromophenyl)acetamide |
|---|---|
| IUPAC Name | — |
| CAS Number | 621-38-5 |
| Database ID | 12123 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
N-(3-bromophenyl)acetamide (CAS 621-38-5) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 12123
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-43a8b6fc6d2d424ab73d1cfd66c92311Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-816f3f6643bf4b4a8fe6587afc453a44Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-a31349d623694a49aa181b27b2b9c90fConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c1e95ec78bfa4b06904dc3fafd66fc60Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-9dd06a3aeed64b4d8ba2ea4fe7dbab1bConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-110661fada1a40b69ff93267927e0650Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-43a8b6fc6d2d424ab73d1cfd66c92311Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-816f3f6643bf4b4a8fe6587afc453a44Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-816f3f6643bf4b4a8fe6587afc453a44Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a manner similar to that of Example (27b), by reaction of 820 mg (20.5 mmol, 1.1 eq) of 60% sodium hydride, 4.0 g (18.7 mmol, 1 eq) of N-(3-bromophenyl)acetamide (prepared in Example 27a) and 2.20 mL (22.4 mmol, 1.2 eq) of 1-iodopropane in 15 ml of tetrahydrofuran in the presence of 1.5 ml of dimethylformamide, N-(3-bromophenyl)-N-propylacetamide is obtained in oil form and is used in the following reaction without further purification.
Source ID: ord-b8c72420ab1243119e5a952cb08513baConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a manner similar to that of Example (27b), by reaction of 820 mg (20.5 mmol, 1.1 eq) of 60% sodium hydride, 4.0 g (18.7 mmol, 1 eq) of N-(3-bromophenyl)acetamide (prepared in Example 27a) and 2.20 mL (22.4 mmol, 1.2 eq) of 1-iodopropane in 15 ml of tetrahydrofuran in the presence of 1.5 ml of dimethylformamide, N-(3-bromophenyl)-N-propylacetamide is obtained in oil form and is used in the following reaction without further purification.
Source ID: ord-b8c72420ab1243119e5a952cb08513baConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 820 mg (20.5 mmol, 1.1 eq) of 60% sodium hydride are added to a solution of 4.0 g (18.7 mmol, 1 eq) of N-(3-bromophenyl)acetamide and 1.80 mL (22.4 mmol, 1.2 eq) of ethyl iodide in 15 ml of tetrahydrofuran in the presence of 1.5 ml of dimethylformamide. The reaction medium is stirred at room temperature for 12 hours and then hydrolyzed with water and extracted with ethyl acetate. The organic phases are combined, washed with sodium chloride solution and dried over sodium sulfate. The solvents are evaporated off and the N-(3-bromophenyl)-N-ethylacetamide obtained in oil form is used in the following reaction without further purification. hydrolyzed with water and extracted with ethyl acetate washed with sodium chloride solution dried over sodium sulfate The solvents are evaporated off
Source ID: ord-0f32b78ee59147788d54de37ff1276ddPubChem References
These sources are listed in the compound's public database record.
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