benzyl (2S)-2-carbamoylpiperidine-1-carboxylate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of (2S)-1-[(benzyloxy)carbonyl]hexahydro-2-pyridinecarboxylic acid (1 eq), TBTU (1.3 eq), DIPEA (1.3 eq), in DMF (2 M) was stirred at R.T. for 30 min then ammonia in dioxane (4 M, 3 eq) was added and stirring was continued for 2 h. The reaction mixture was diluted with EtOAc, washed sequentially with sat. aq. NaHCO3 solution and brine. The solution was dried (Na2SO4), filtered and concentrated under reduced pressure. The crude was purified by crystallization from Et2O giving a white solid. MS (ES) C14H18N2O3 required: 262, found: 263 (M+H)+. washed sequentially with sat. aq. NaHCO3 solution and brine The solution was dried (Na2SO4) filtered concentrated under reduced pressure The crude was purified by crystallization from Et2O giving a white solid

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of (2S)-1-[(benzyloxy)carbonyl]hexahydro-2-pyridinecarboxylic acid (1 eq), TBTU (1.3 eq), DIPEA (1.3 eq), in DMF (2 M) was stirred at R.T. for 30 min then ammonia in dioxane (4 M, 3 eq) was added and stirring was continued for 2 h. The reaction mixture was diluted with EtOAc, washed sequentially with sat. aq. NaHCO3 solution and brine. The solution was dried (Na2SO4), filtered and concentrated under reduced pressure. The crude was purified by crystallization from Et2O giving a white solid. MS (ES) C14H18N2O3 required: 262, found: 263 (M+H)+. washed sequentially with sat. aq. NaHCO3 solution and brine The solution was dried (Na2SO4) filtered concentrated under reduced pressure The crude was purified by crystallization from Et2O giving a white solid