No renderable structure data available
COC(=O)C1=C(C2=CC=CC=C2O1)CBrChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | methyl 3-(bromomethyl)-1-benzofuran-2-carboxylate |
|---|---|
| IUPAC Name | — |
| CAS Number | 58763-73-8 |
| Database ID | 100838 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
methyl 3-(bromomethyl)-1-benzofuran-2-carboxylate (CAS 58763-73-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 100838
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-baf2e84d226a4374b0c399d24c432e30Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c42e3bbca403425f991dc87bb31b5843Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c42e3bbca403425f991dc87bb31b5843Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-c42e3bbca403425f991dc87bb31b5843Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Sodium hydride (15 mg, 0.56 mmol) was suspended in anhydrous DMF and stirred under N2(g). 2,2,2-Trifluoroethanol (270 μL, 3.7 mmol) was added and after stirring the reaction mixture for 15-20 min., 3-bromomethylbenzofuran-2-carboxylic acid methyl ester was added. After 8 h, 1N NaOH (aq.) was added and the reaction mixture was stirred for 10-15 min. The reaction mixture was acidified reaction to pH 3 with aqueous hydrochloric acid and the product was extracted with EtOAc. The organic layer was dried organic over Na2SO4 and concentrated in vacuo to give 3-(2,2,2-trifluoroethoxymethyl)benzofuran-2-carboxylic acid (38 mg) which was then used without purification. after stirring the reaction mixture for 15-20 min. the reaction mixture was stirred for 10-15 min the product was extracted with EtOAc concentrated in vacuo
Source ID: ord-a75a77a5c44a49279363f5abbe636f88Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3-Bromomethylbenzofuran-2-carboxylic acid methyl ester (269 mg, 1 mmol) was dissolved in anhydrous DMF and added 2M dimethylamine/THF solution (1.5 ml, 3 mmol). After 1-2 h, the reaction was diluted with EtOAc and washed twice with saturated NaHCO3 (aq.) and brine. The organic extract over was dried over Na2SO4 and then concentrated in vacuo. The crude was purified on a silica gel column (5% MeOH in dichloromethane) to give 3-dimethylaminomethylbenzofuran-2-carboxylic acid methyl ester (131 mg). washed twice with saturated NaHCO3 (aq.) and brine The organic extract over was dried over Na2SO4 concentrated in vacuo The crude was purified on a silica gel column (5% MeOH in dichloromethane)
Source ID: ord-a94fb4e1a67849fa93c242eadfb1f472Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Sodium hydride (15 mg, 0.56 mmol) was suspended in anhydrous DMF and stirred under N2(g). 2,2,2-Trifluoroethanol (270 μL, 3.7 mmol) was added and after stirring the reaction mixture for 15-20 min., 3-bromomethylbenzofuran-2-carboxylic acid methyl ester was added. After 8 h, 1N NaOH (aq.) was added and the reaction mixture was stirred for 10-15 min. The reaction mixture was acidified reaction to pH 3 with aqueous hydrochloric acid and the product was extracted with EtOAc. The organic layer was dried organic over Na2SO4 and concentrated in vacuo to give 3-(2,2,2-trifluoroethoxymethyl)benzofuran-2-carboxylic acid (38 mg) which was then used without purification. after stirring the reaction mixture for 15-20 min. the reaction mixture was stirred for 10-15 min the product was extracted with EtOAc concentrated in vacuo
Source ID: ord-0b81eb893faa4199a158c8e195a94d9eConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3-Bromomethylbenzofuran-2-carboxylic acid methyl ester (269 mg, 1 mmol) was dissolved in anhydrous DMF and added 2M dimethylamine/THF solution (1.5 ml, 3 mmol). After 1-2 h, the reaction was diluted with EtOAc and washed twice with saturated NaHCO3 (aq.) and brine. The organic extract over was dried over Na2SO4 and then concentrated in vacuo. The crude was purified on a silica gel column (5% MeOH in dichloromethane) to give 3-dimethylaminomethylbenzofuran-2-carboxylic acid methyl ester (131 mg). washed twice with saturated NaHCO3 (aq.) and brine The organic extract over was dried over Na2SO4 concentrated in vacuo The crude was purified on a silica gel column (5% MeOH in dichloromethane)
Source ID: ord-c94ef03950294d5ea886447b70b878deConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Sodium hydride (15 mg, 0.56 mmol) was suspended in anhydrous DMF and stirred under N2(g). 2,2,2-Trifluoroethanol (270 μL, 3.7 mmol) was added and after stirring the reaction mixture for 15-20 min., 3-bromomethylbenzofuran-2-carboxylic acid methyl ester was added. After 8 h, 1N NaOH (aq.) was added and the reaction mixture was stirred for 10-15 min. The reaction mixture was acidified reaction to pH 3 with aqueous hydrochloric acid and the product was extracted with EtOAc. The organic layer was dried organic over Na2SO4 and concentrated in vacuo to give 3-(2,2,2-trifluoroethoxymethyl)benzofuran-2-carboxylic acid (38 mg) which was then used without purification. after stirring the reaction mixture for 15-20 min. the reaction mixture was stirred for 10-15 min the product was extracted with EtOAc concentrated in vacuo
Source ID: ord-66ad7b0b78f64b6891b5b38e7b0a4f68Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3-Bromomethylbenzofuran-2-carboxylic acid methyl ester (269 mg, 1 mmol) was dissolved in anhydrous DMF and added 2M dimethylamine/THF solution (1.5 ml, 3 mmol). After 1-2 h, the reaction was diluted with EtOAc and washed twice with saturated NaHCO3 (aq.) and brine. The organic extract over was dried over Na2SO4 and then concentrated in vacuo. The crude was purified on a silica gel column (5% MeOH in dichloromethane) to give 3-dimethylaminomethylbenzofuran-2-carboxylic acid methyl ester (131 mg). washed twice with saturated NaHCO3 (aq.) and brine The organic extract over was dried over Na2SO4 concentrated in vacuo The crude was purified on a silica gel column (5% MeOH in dichloromethane)
Source ID: ord-b1416ea525ae4d63acecfe128d80009bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Sodium hydride (15 mg, 0.56 mmol) was suspended in anhydrous DMF and stirred under N2(g). 2,2,2-Trifluoroethanol (270 μL, 3.7 mmol) was added and after stirring the reaction mixture for 15-20 min., 3-bromomethylbenzofuran-2-carboxylic acid methyl ester was added. After 8 h, 1N NaOH (aq.) was added and the reaction mixture was stirred for 10-15 min. The reaction mixture was acidified reaction to pH 3 with aqueous hydrochloric acid and the product was extracted with EtOAc. The organic layer was dried organic over Na2SO4 and concentrated in vacuo to give 3-(2,2,2-trifluoroethoxymethyl)benzofuran-2-carboxylic acid (38 mg) which was then used without purification. after stirring the reaction mixture for 15-20 min. the reaction mixture was stirred for 10-15 min the product was extracted with EtOAc concentrated in vacuo
Source ID: ord-66ad7b0b78f64b6891b5b38e7b0a4f68Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 3-Bromomethylbenzofuran-2-carboxylic acid methyl ester (269 mg, 1 mmol) was dissolved in anhydrous DMF and added 2M dimethylamine/THF solution (1.5 ml, 3 mmol). After 1-2 h, the reaction was diluted with EtOAc and washed twice with saturated NaHCO3 (aq.) and brine. The organic extract over was dried over Na2SO4 and then concentrated in vacuo. The crude was purified on a silica gel column (5% MeOH in dichloromethane) to give 3-dimethylaminomethylbenzofuran-2-carboxylic acid methyl ester (131 mg). washed twice with saturated NaHCO3 (aq.) and brine The organic extract over was dried over Na2SO4 concentrated in vacuo The crude was purified on a silica gel column (5% MeOH in dichloromethane)
Source ID: ord-b1416ea525ae4d63acecfe128d80009bPubChem References
These sources are listed in the compound's public database record.
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