(2R)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In a similar procedure as employed in the Intermediate Example 1, D-proline amide (3.2 g) was reacted with chloroacetyl chloride (2.5 ml) and then subjected to dehydration reaction to give the title compound (3.2 g, Y.:66%). subjected to dehydration reaction