methyl 3,3-dimethyloxirane-2-carboxylate

Conditions: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Methyl 3,3-dimethylglycidate (20.0 g, 0.154 mmol) and ethanol (30 mL) were introduced into an eggplant type flask (100 cc) and stirred at room temperature while 70% perchloric acid (5 drops) was added gradually. The resulting reaction solution was heated at 50° C. for 2 hours with stirring. After completion of the reaction, the reaction solution was concentrated under reduced pressure, and a small amount of anhydrous sodium carbonate was added. The reaction solution was left to stand at room temperature for a while, and then the solid was removed by filtration to obtain methyl 3-ethoxy-2-hydroxy-3-methylbutanoate (24.9 g, yield 91.6%) as a transparent liquid. was added gradually The resulting reaction solution After completion of the reaction the reaction solution was concentrated under reduced pressure a small amount of anhydrous sodium carbonate was added The reaction solution was left to stand at room temperature for a while the solid was removed by filtration

Conditions: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Methyl 3,3-dimethylglycidate (20.0 g, 0.154 mmol) and ethanol (30 mL) were introduced into an eggplant type flask (100 cc) and stirred at room temperature while 70% perchloric acid (5 drops) was added gradually. The resulting reaction solution was heated at 50° C. for 2 hours with stirring. After completion of the reaction, the reaction solution was concentrated under reduced pressure, and a small amount of anhydrous sodium carbonate was added. The reaction solution was left to stand at room temperature for a while, and then the solid was removed by filtration to obtain methyl 3-ethoxy-2-hydroxy-3-methylbutanoate (24.9 g, yield 91.6%) as a transparent liquid. was added gradually The resulting reaction solution After completion of the reaction the reaction solution was concentrated under reduced pressure a small amount of anhydrous sodium carbonate was added The reaction solution was left to stand at room temperature for a while the solid was removed by filtration