iodomethylcyclohexane

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In the same manner as in Preparation Example 70-2, the objective compound (797 mg, 56%) was obtained as a colorless oil from 4-bromo-1-((tert-butyldiphenylsilyloxy)methyl)-2-chlorobenzene and cyclohexylmethyl iodide. In the same manner as in Preparation Example 70-2

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: This compound is prepared from 3 g (8 mmol) of methyl 6-methyl-3-nitro-2-oxo-4-[[(trifluoromethyl)-sulphonyl]oxy]-1,2-dihydropyridine-1-acetate and 5.45 g (24.3 mmol) of cyclohexylmethyl iodide according to the method described in Example 1.5. 1.3 g of product are obtained in the form of yellow crystals.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: This compound is prepared from 3 g (8 mmol) of methyl 6-methyl-3-nitro-2-oxo-4-[[(trifluoromethyl)-sulphonyl]oxy]-1,2-dihydropyridine-1-acetate and 5.45 g (24.3 mmol) of cyclohexylmethyl iodide according to the method described in Example 1.5. 1.3 g of product are obtained in the form of yellow crystals.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound is prepared from 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one and iodomethylcyclohexane analogous to Example 57, steps B, C and D: (M−1)−=323. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.89 (d, J=11.37 Hz, 2 H) 1.09-1.19 (m, 2 H) 1.14 (d, J=9.60 Hz, 1 H) 1.44 (dd, J=14.78, 3.66 Hz, 1 H) 1.62 (d, J=10.86 Hz, 5 H) 2.34 (d, J=7.07 Hz, 2 H) 4.00 (s, 2 H) 6.54 (dd, J=7.96, 1.89 Hz, 1 H) 6.61 (d, J=1.77 Hz, 1 H) 7.25 (d, J=8.08 Hz, 1 H) 8.85 (s, 1 H)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In the same manner as in Preparation Example 70-2, the objective compound (797 mg, 56%) was obtained as a colorless oil from 4-bromo-1-((tert-butyldiphenylsilyloxy)methyl)-2-chlorobenzene and cyclohexylmethyl iodide. In the same manner as in Preparation Example 70-2

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In the same manner as in Preparation Example 70-2, the objective compound (797 mg, 56%) was obtained as a colorless oil from 4-bromo-1-((tert-butyldiphenylsilyloxy)methyl)-2-chlorobenzene and cyclohexylmethyl iodide. In the same manner as in Preparation Example 70-2

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: This compound is prepared from 3 g (8 mmol) of methyl 6-methyl-3-nitro-2-oxo-4-[[(trifluoromethyl)-sulphonyl]oxy]-1,2-dihydropyridine-1-acetate and 5.45 g (24.3 mmol) of cyclohexylmethyl iodide according to the method described in Example 1.5. 1.3 g of product are obtained in the form of yellow crystals.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The title compound is prepared from 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one and iodomethylcyclohexane analogous to Example 57, steps B, C and D: (M−1)−=323. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.89 (d, J=11.37 Hz, 2 H) 1.09-1.19 (m, 2 H) 1.14 (d, J=9.60 Hz, 1 H) 1.44 (dd, J=14.78, 3.66 Hz, 1 H) 1.62 (d, J=10.86 Hz, 5 H) 2.34 (d, J=7.07 Hz, 2 H) 4.00 (s, 2 H) 6.54 (dd, J=7.96, 1.89 Hz, 1 H) 6.61 (d, J=1.77 Hz, 1 H) 7.25 (d, J=8.08 Hz, 1 H) 8.85 (s, 1 H)