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CCOP(=O)(CCC1=CC=CC=C1)OCCChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-diethoxyphosphorylethylbenzene |
|---|---|
| IUPAC Name | — |
| CAS Number | 54553-21-8 |
| Database ID | 3448525 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-diethoxyphosphorylethylbenzene (CAS 54553-21-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 3448525
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-42d0a2a304ff433c95ee028c94e43343Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b2d899b2ab83492585390d4db668c906Conditions: temp:-15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl phosphite (27.64 g, 200 m mole) was dissolved in DMF (200 ml), and to the solution at nitrogen atmosphere while stirring and -15° C., sodium hydride (60% in oil, 9.6 g, 220 m mole) was added. The mixture was stirred for 1 hour at not more than 0° C. To the solution phenethyl bromide (37.0 g, 200 m mole) was dropwise added and further the mixture was stirred overnight at room temperature. The DMF solution was distilled under reduced pressure leaving a residue, and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated and the thus obtained oily product was distilled under reduced pressure to obtain diethylphenethylphosphonate (25.0 g, yield: 51.6%) of boiling point 136.5°~137.5° C./3 mmHg. The mixture was stirred for 1 hour at not more than 0° C further the mixture was stirred overnight at room temperature The DMF solution was distilled under reduced pressure leaving a residue The ethyl acetate solution was washed with water dried with anhydrous sodium sulfate The solvent was evaporated the thus obtained oily product was distilled under reduced pressure
Source ID: ord-6cdc5fd140114cde9c4f1e2190f32365Conditions: temp:-15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl phosphite (27.64 g, 200 m mole) was dissolved in DMF (200 ml), and to the solution at nitrogen atmosphere while stirring and -15° C., sodium hydride (60% in oil, 9.6 g, 220 m mole) was added. The mixture was stirred for 1 hour at not more than 0° C. To the solution phenethyl bromide (37.0 g, 200 m mole) was dropwise added and further the mixture was stirred overnight at room temperature. The DMF solution was distilled under reduced pressure leaving a residue, and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated and the thus obtained oily product was distilled under reduced pressure to obtain diethylphenethylphosphonate (25.0 g, yield: 51.6%) of boiling point 136.5°~137.5° C./3 mmHg. The mixture was stirred for 1 hour at not more than 0° C further the mixture was stirred overnight at room temperature The DMF solution was distilled under reduced pressure leaving a residue The ethyl acetate solution was washed with water dried with anhydrous sodium sulfate The solvent was evaporated the thus obtained oily product was distilled under reduced pressure
Source ID: ord-6cdc5fd140114cde9c4f1e2190f32365Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a manner according to Preparation 2 combine 2-phenylethyl bromide and triethyl phosphite. Distill the mixture at reduced pressure (0.15 mm Hg) and collect the fraction distilling at 115°-130° C. to obtain the title compound. Distill the mixture at reduced pressure (0.15 mm Hg) collect the fraction distilling at 115°-130° C.
Source ID: ord-5fdc8f3c0f904a119539b199c5f50e6dConditions: temp:-15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl phosphite (27.64 g, 200 m mole) was dissolved in DMF (200 ml), and to the solution at nitrogen atmosphere while stirring and -15° C., sodium hydride (60% in oil, 9.6 g, 220 m mole) was added. The mixture was stirred for 1 hour at not more than 0° C. To the solution phenethyl bromide (37.0 g, 200 m mole) was dropwise added and further the mixture was stirred overnight at room temperature. DMF was distilled off under reduced pressure, and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated and the thus obtained oily product was distilled under reduced pressure to obtain diethylphenethylphosphonate (25.0 g, yield: 51.6%) of boiling point 136.5~137.5° C./3 mmHg. The mixture was stirred for 1 hour at not more than 0° C further the mixture was stirred overnight at room temperature DMF was distilled off under reduced pressure the residue was dissolved in ethyl acetate The ethyl acetate solution was washed with water dried with anhydrous sodium sulfate The solvent was evaporated the thus obtained oily product was distilled under reduced pressure
Source ID: ord-7c5f995c6a5f42f18e9fa1aeb49db21dConditions: temp:-15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl phosphite (27.64 g, 200 m mole) was dissolved in DMF (200 ml), and to the solution at nitrogen atmosphere while stirring and -15° C., sodium hydride (60% in oil, 9.6 g, 220 m mole) was added. The mixture was stirred for 1 hour at not more than 0° C. To the solution phenethyl bromide (37.0 g, 200 m mole) was dropwise added and further the mixture was stirred overnight at room temperature. The DMF solution was distilled under reduced pressure leaving a residue, and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated and the thus obtained oily product was distilled under reduced pressure to obtain diethylphenethylphosphonate (25.0 g, yield: 51.6%) of boiling point 136.5°~137.5° C./3 mmHg. The mixture was stirred for 1 hour at not more than 0° C further the mixture was stirred overnight at room temperature The DMF solution was distilled under reduced pressure leaving a residue The ethyl acetate solution was washed with water dried with anhydrous sodium sulfate The solvent was evaporated the thus obtained oily product was distilled under reduced pressure
Source ID: ord-6cdc5fd140114cde9c4f1e2190f32365Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-42d0a2a304ff433c95ee028c94e43343Conditions: temp:-15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl phosphite (27.64 g, 200 m mole) was dissolved in DMF (200 ml), and to the solution at nitrogen atmosphere while stirring and -15° C., sodium hydride (60% in oil, 9.6 g, 220 m mole) was added. The mixture was stirred for 1 hour at not more than 0° C. To the solution phenethyl bromide (37.0 g, 200 m mole) was dropwise added and further the mixture was stirred overnight at room temperature. The DMF solution was distilled under reduced pressure leaving a residue, and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated and the thus obtained oily product was distilled under reduced pressure to obtain diethylphenethylphosphonate (25.0 g, yield: 51.6%) of boiling point 136.5°~137.5° C./3 mmHg. The mixture was stirred for 1 hour at not more than 0° C further the mixture was stirred overnight at room temperature The DMF solution was distilled under reduced pressure leaving a residue The ethyl acetate solution was washed with water dried with anhydrous sodium sulfate The solvent was evaporated the thus obtained oily product was distilled under reduced pressure
Source ID: ord-dcd0f02eba574f799999b6ccd76afd91Conditions: temp:-15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl phosphite (27.64 g, 200 m mole) was dissolved in DMF (200 ml), and to the solution at nitrogen atmosphere while stirring and -15° C., sodium hydride (60% in oil, 9.6 g, 220 m mole) was added. The mixture was stirred for 1 hour at not more than 0° C. To the solution phenethyl bromide (37.0 g, 200 m mole) was dropwise added and further the mixture was stirred overnight at room temperature. The DMF solution was distilled under reduced pressure leaving a residue, and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated and the thus obtained oily product was distilled under reduced pressure to obtain diethylphenethylphosphonate (25.0 g, yield: 51.6%) of boiling point 136.5°~137.5° C./3 mmHg. The mixture was stirred for 1 hour at not more than 0° C further the mixture was stirred overnight at room temperature The DMF solution was distilled under reduced pressure leaving a residue The ethyl acetate solution was washed with water dried with anhydrous sodium sulfate The solvent was evaporated the thus obtained oily product was distilled under reduced pressure
Source ID: ord-dcd0f02eba574f799999b6ccd76afd91Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In a manner according to Preparation 2 combine 2-phenylethyl bromide and triethyl phosphite. Distill the mixture at reduced pressure (0.15 mm Hg) and collect the fraction distilling at 115°-130° C. to obtain the title compound. Distill the mixture at reduced pressure (0.15 mm Hg) collect the fraction distilling at 115°-130° C.
Source ID: ord-5fdc8f3c0f904a119539b199c5f50e6dConditions: temp:-15.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl phosphite (27.64 g, 200 m mole) was dissolved in DMF (200 ml), and to the solution at nitrogen atmosphere while stirring and -15° C., sodium hydride (60% in oil, 9.6 g, 220 m mole) was added. The mixture was stirred for 1 hour at not more than 0° C. To the solution phenethyl bromide (37.0 g, 200 m mole) was dropwise added and further the mixture was stirred overnight at room temperature. DMF was distilled off under reduced pressure, and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated and the thus obtained oily product was distilled under reduced pressure to obtain diethylphenethylphosphonate (25.0 g, yield: 51.6%) of boiling point 136.5~137.5° C./3 mmHg. The mixture was stirred for 1 hour at not more than 0° C further the mixture was stirred overnight at room temperature DMF was distilled off under reduced pressure the residue was dissolved in ethyl acetate The ethyl acetate solution was washed with water dried with anhydrous sodium sulfate The solvent was evaporated the thus obtained oily product was distilled under reduced pressure
Source ID: ord-7c5f995c6a5f42f18e9fa1aeb49db21dPubChem References
These sources are listed in the compound's public database record.
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