No renderable structure data available
CC1(C(O1)C(=O)OC)C2=CC=CC=C2Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | methyl 3-methyl-3-phenyloxirane-2-carboxylate |
|---|---|
| IUPAC Name | — |
| CAS Number | 5441-04-3 |
| Database ID | 228011 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
methyl 3-methyl-3-phenyloxirane-2-carboxylate (CAS 5441-04-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 228011
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7fd1fb553c6a416181061c126a424cf1Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-eed76475c00f456ca742fb9e8a0e6552Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 51.9 g (0.3 mol) of 4-bromophenol and 19.2 g (0.1 mol) of methyl 3-phenyl-2,3-epoxybutyrate are stirred at 100° C. for 8 hours and at room temperature for 12 hour. After removal of the excess phenol by distillation, the residue is purified by flash chromatography (silica gel, n-hexane/ethyl acetate 9:1) to result in 7.2 g of a white solid. After removal of the excess phenol by distillation the residue is purified by flash chromatography (silica gel, n-hexane/ethyl acetate 9:1)
Source ID: ord-d9675b544e26491989ee50b08f760dbeConditions: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 9.6 g (50 mmol) of methyl 3-phenyl-2,3-epoxybutyrate are dissolved in 150 ml of benzyl alcohol, and 0.5 ml of concentrated sulfuric acid is added. The mixture is stirred at 50° C. for 6 hours and allowed to cool to room temperature. After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum, and the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate. After removal of the solvent by distillation, 6.5 g of a colorless oil remain. to cool to room temperature After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate After removal of the solvent by distillation, 6.5 g of a colorless oil
Source ID: ord-ec22ef5365b144248f249b920c5151a0Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 51.9 g (0.3 mol) of 4-bromophenol and 19.2 g (0.1 mol) of methyl 3-phenyl-2,3-epoxybutyrate are stirred at 100° C. for 8 h and at room temperature for 12 h. After removal of the excess phenol by distillation, the residue is purified by flash chromatography (silica gel, n-hexane/ethyl acetate 9:1) to result in 7.2 g of a white solid. After removal of the excess phenol by distillation the residue is purified by flash chromatography (silica gel, n-hexane/ethyl acetate 9:1)
Source ID: ord-14124aa0e8a44e7292a3a62925bde09fConditions: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 9.6 g (50 mmol) of methyl 3-phenyl-2,3-epoxybutyrate are dissolved in 150 ml of benzyl alcohol, and 0.5 ml of concentrated sulfuric acid is added. The mixture is stirred at 50° C. for 6 hours and allowed to cool to room temperature. After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum, and the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate. After removal of the solvent by distillation, 6.5 g of a colorless oil remain. to cool to room temperature After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate After removal of the solvent by distillation, 6.5 g of a colorless oil
Source ID: ord-afe9f54ad3f14695a2cdf9ae4e5dd264Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 51.9 g (0.3 mol) of 4-bromophenol and 19.2 g (0.1 mol) of methyl 3-phenyl-2,3-epoxybutyrate are stirred at 100° C. for 8 hours and at room temperature for 12 hour. After removal of the excess phenol by distillation, the residue is purified by flash chromatography (silica gel, n-hexane/ethyl acetate 9:1) to result in 7.2 g of a white solid. After removal of the excess phenol by distillation the residue is purified by flash chromatography (silica gel, n-hexane/ethyl acetate 9:1)
Source ID: ord-d9675b544e26491989ee50b08f760dbeConditions: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 9.6 g (50 mmol) of methyl 3-phenyl-2,3-epoxybutyrate are dissolved in 150 ml of benzyl alcohol, and 0.5 ml of concentrated sulfuric acid is added. The mixture is stirred at 50° C. for 6 hours and allowed to cool to room temperature. After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum, and the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate. After removal of the solvent by distillation, 6.5 g of a colorless oil remain. to cool to room temperature After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate After removal of the solvent by distillation, 6.5 g of a colorless oil
Source ID: ord-ec22ef5365b144248f249b920c5151a0Conditions: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 9.6 g (50 mmol) of methyl 3-phenyl-2,3-epoxybutyrate are dissolved in 150 ml of benzyl alcohol, and 0.5 ml of concentrated sulfuric acid is added. The mixture is stirred at 50° C. for 6 hours and allowed to cool to room temperature. After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum, and the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate. After removal of the solvent by distillation, 6.5 g of a colorless oil remain. to cool to room temperature After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate After removal of the solvent by distillation, 6.5 g of a colorless oil
Source ID: ord-ec22ef5365b144248f249b920c5151a0Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 51.9 g (0.3 mol) of 4-bromophenol and 19.2 g (0.1 mol) of methyl 3-phenyl-2,3-epoxybutyrate are stirred at 100° C. for 8 h and at room temperature for 12 h. After removal of the excess phenol by distillation, the residue is purified by flash chromatography (silica gel, n-hexane/ethyl acetate 9:1) to result in 7.2 g of a white solid. After removal of the excess phenol by distillation the residue is purified by flash chromatography (silica gel, n-hexane/ethyl acetate 9:1)
Source ID: ord-14124aa0e8a44e7292a3a62925bde09fConditions: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: 9.6 g (50 mmol) of methyl 3-phenyl-2,3-epoxybutyrate are dissolved in 150 ml of benzyl alcohol, and 0.5 ml of concentrated sulfuric acid is added. The mixture is stirred at 50° C. for 6 hours and allowed to cool to room temperature. After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum, and the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate. After removal of the solvent by distillation, 6.5 g of a colorless oil remain. to cool to room temperature After neutralization with sodium bicarbonate solution, the excess benzyl alcohol is removed by distillation under high vacuum the residue is purified by flash chromatography on silica gel with 9:1 n-hexane/ethyl acetate After removal of the solvent by distillation, 6.5 g of a colorless oil
Source ID: ord-afe9f54ad3f14695a2cdf9ae4e5dd264Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7fd1fb553c6a416181061c126a424cf1PubChem References
These sources are listed in the compound's public database record.
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