No renderable structure data available
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2,2-diphenylacetamide |
|---|---|
| IUPAC Name | — |
| CAS Number | 4695-13-0 |
| Database ID | 78420 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2,2-diphenylacetamide (CAS 4695-13-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 78420
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-5478f7bb6c5b4a7eb47bc48265abf23bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound, white solid, m.p. 83° C. and MS: m/e=296.3 (M+H+) was prepared in accordance with the general method of example 39 from 2,2-diphenylacetamide and butanecarboxylic acid chloride.
Source ID: ord-eeae5903f0134fb2b4b87fe619e49885Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound, white solid, m.p. 87° C. and MS: m/e=309 (M+) was prepared in accordance with the general method of example 39 from 2,2-diphenylacetamide and pentanecarboxylic acid chloride.
Source ID: ord-ac094164367c4817949da7dc6a3630aeConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound, white solid, m.p. 205° C. and MS: m/e=281 (M+) was prepared in accordance with the general method of example 39 from 2,2-diphenylacetamide and propanecarboxylic acid chloride.
Source ID: ord-54636a99fa394192b67291ea953f2f57Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred and cooled (0° C.) solution of 2,2-diphenylacetamide (500 mg, 2.36 mmol) in THF (20 ml) was added sodium hydride (95 mg, 2.36 mmol; 60%) and the mixture was stirred at RT for 0.5 h. Then cyclopropanecarboxylic acid chloride(247 mg, 2.36 mmol) dissolved in THF (5 ml) was added dropwise at RT and the solution was stirred at RT for 20 h. The reaction mixture was poured into sat. NaHCO3 solution (50 ml) and extracted with ethyl acetate (2×70 ml). The combined organic layers were washed with brine (50 ml), dried (MgSO4) and evaporated. Further purification by column chromatography (toluene/ethyl acetate 19:1) yielded the product which was recrystallized from ethyl acetate/hexane to give a white solid (133 mg, 20%), m.p. 178° C. and MS: m/e=279 (M+). the mixture was stirred at RT for 0.5 h was added dropwise at RT the solution was stirred at RT for 20 h extracted with ethyl acetate (2×70 ml) The combined organic layers were washed with brine (50 ml) dried (MgSO4) evaporated Further purification by column chromatography (toluene/ethyl acetate 19:1) yielded the product which was recrystallized from ethyl acetate/hexane
Source ID: ord-91c362153a5144c98988f42a66dc0ce8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound, white solid, m.p. 83° C. and MS: m/e=296.3 (M+H+) was prepared in accordance with the general method of example 39 from 2,2-diphenylacetamide and butanecarboxylic acid chloride.
Source ID: ord-cca6da205f6345b8adf4f0ea4ee6a707Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound, white solid, m.p. 87° C. and MS: m/e=309 (M+) was prepared in accordance with the general method of example 39 from 2,2-diphenylacetamide and pentanecarboxylic acid chloride.
Source ID: ord-d344076e7874441b89a1efc1618b8b6eConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound, white solid, m.p. 87° C. and MS: m/e=309 (M+) was prepared in accordance with the general method of example 39 from 2,2-diphenylacetamide and pentanecarboxylic acid chloride.
Source ID: ord-d344076e7874441b89a1efc1618b8b6eConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound, white solid, m.p. 205° C. and MS: m/e=281 (M+) was prepared in accordance with the general method of example 39 from 2,2-diphenylacetamide and propanecarboxylic acid chloride.
Source ID: ord-9ea94b919a5a4e1baa2add77dcf68652Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a stirred and cooled (0° C.) solution of 2,2-diphenylacetamide (500 mg, 2.36 mmol) in THF (20 ml) was added sodium hydride (95 mg, 2.36 mmol; 60%) and the mixture was stirred at RT for 0.5 h. Then cyclopropanecarboxylic acid chloride (247 mg, 2.36 mmol) dissolved in THF (5 ml) was added dropwise at RT and the solution was stirred at RT for 20 h. The reaction mixture was poured into sat. NaHCO3 solution (50 ml) and extracted with ethyl acetate (2×70 ml). The combined organic layers were washed with brine (50 ml), dried (MgSO4) and evaporated. Further purification by column chromatography (toluene/ethyl acetate 19:1) yielded the product which was recrystallized from ethyl acetate/hexane to give a white solid (133 mg, 20%), m.p. 178° C. and MS: m/e=279 (M+). the mixture was stirred at RT for 0.5 h was added dropwise at RT the solution was stirred at RT for 20 h extracted with ethyl acetate (2×70 ml) The combined organic layers were washed with brine (50 ml) dried (MgSO4) evaporated Further purification by column chromatography (toluene/ethyl acetate 19:1) yielded the product which was recrystallized from ethyl acetate/hexane
Source ID: ord-811f500ed9274f3eaafac27bedd6658eConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound, white solid, m.p. 83° C. and MS: m/e=296.3 (M+H+) was prepared in accordance with the general method of example 39 from 2,2-diphenylacetamide and butanecarboxylic acid chloride.
Source ID: ord-eeae5903f0134fb2b4b87fe619e49885Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The title compound, white solid, m.p. 83° C. and MS: m/e=296.3 (M+H+) was prepared in accordance with the general method of example 39 from 2,2-diphenylacetamide and butanecarboxylic acid chloride.
Source ID: ord-eeae5903f0134fb2b4b87fe619e49885PubChem References
These sources are listed in the compound's public database record.
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