tert-butyl (2S)-2-carbamoyl-4,4-difluoropyrrolidine-1-carboxylate

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 9.54 mL of trifluoroacetic acid was added to a solution of (S)-tert-butyl 2-carbamoyl-4,4-difluoropyrrolidine-1-carboxylate (1.25 g, 5 mmol) in 10 mL of dichloromethane. The solution was stirred for 1 hour before evaporation. The residue was washed with ether to yield white crystals. The residue was washed with ether to yield white crystals

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 9.54 mL of trifluoroacetic acid was added to a solution of (S)-tert-butyl 2-carbamoyl-4,4-difluoropyrrolidine-1-carboxylate (1.25 g, 5 mmol) in 10 mL of dichloromethane. The solution was stirred for 1 hour before evaporation. The residue was washed with ether to yield white crystals. The residue was washed with ether to yield white crystals

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 9.54 mL of trifluoroacetic acid was added to a solution of (S)-tert-butyl 2-carbamoyl-4,4-difluoropyrrolidine-1-carboxylate (1.25 g, 5 mmol) in 10 mL of dichloromethane. The solution was stirred for 1 hour before evaporation. The residue was washed with ether to yield white crystals. The residue was washed with ether to yield white crystals