1-phenyl-2-piperazin-1-ylethanone;dihydrochloride

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of (2-benzenesulfonylmethyl)-benzyl bromide (0.5 g, 1.54 mmol), N-phenacyl piperazine dihydrochloride (0.32 g, 1.54 mmol) and K2CO3 (0.74 g, 5.38 mmol) in 40 ml of acetone was treated according to general preparation 2 to give 0.4 g of compound (IV-26), yield 50%. M+ 448. was treated according to general preparation 2

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 3-methoxybenzylchloride (0.5 g, 2.15 mmol), N-phenacyl piperazine dihydrochloride (0.6 g, 2.15 mmol) and K2CO3 (1.04 g, 7.52 mmol) in 30 ml of acetone was treated according to general preparation 2 to give 0.46 g of compound (IV-25), yield 54%. M+ 324. was treated according to general preparation 2

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of N-phenacyl piperazine dihydrochloride (1.39 g, 5 mmol), 1-(1-chloroethyl)-4-fluorobenzene (0.95 g, 6 mmol) and K2CO3 (2.42 g, 17.5 mmol) in 40 ml of acetone was treated according to general preparation 2 to give 1.25 g of compound (IV-24), yield 61%. M+ 326. was treated according to general preparation 2

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of N-phenacyl piperazine dihydrochloride (1.7 g, 6.1 mmol), 2-methoxy-5-nitro-benzylbromide (1.5 g, 6.1 mmol) and K2CO3 (2.7 g, 19.5 mmol) in 40 ml of acetone was treated according to general preparation 2 to give 1.80 g of compound (IV-23), yield 60%. M+ 368. was treated according to general preparation 2

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of N-formyl piperazine 35.5 g (310 mmol), 2-chloro-1-phenylethanone (57.6 g, 372 mmol) and anhydrous K2CO3 (64.3 g, 465 mmol) in 320 ml of acetone was treated according to general preparation 1 to give 49 g of N-phenacyl piperazine dihydrochloride, yield 57%, mp 246-8° C. (dec). M+ 204. was treated according to general preparation 1

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of N-[1-(3,4-methylenedioxyphenyl)methyl]-2-chloroacetamide (5 mmol), N-phenacyl piperazine dihydrochloride (5 mmol) and K2CO3 (17.5 mmol) in 60 ml of acetone was treated according to the general preparation 2 to give compound (IV-32), 0.76 g (63.45%), M+ 395. was treated according to the general preparation 2 to give compound (IV-32), 0.76 g (63.45%), M+ 395

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 2-chloro-N-(pyridin-2-ylmethyl)acetamide (1.3 mmol), N-phenacyl piperazine dihydrochloride (1 mmol), and K2CO3 (8.75 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-31), 0.7 g (60.45%), M+ 381. was treated according to the general preparation 2 to give compound (IV-31), 0.7 g (60.45%), M+ 381

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of N-(4-methoxybenzyl)-2-chloroacetamide (3.65 mmol), N-phenacyl piperazine dihydrochloride (3.97 mmol) and K2CO3 (10.5 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-30)(61%), M+ 381. was treated according to the general preparation 2 to give compound (IV-30)(61%), M+ 381

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 2,4-difluorobenzylsulfonylchloride (3.5 mmol), N-phenacyl piperazine dihydrochloride (3 mmol), and K2CO3 (10.5 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-22), 0.81 g (71%), M+ 412. was treated according to the general preparation 2 to give compound (IV-22), 0.81 g (71%), M+ 412

Conditions: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 2-bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one (3.8 mmol), N-phenacyl piperazine dihydrochloride (0.89 g, 3.2 mmol) and K2CO3 (1.56 g, 11.2 mmol) in 30 ml of DMF are stirred at 50° C. for 10 h, then was treated according to the general preparation 2 to give compound(IV-19), 1.09 g (61%), M+ 451. was treated according to the general preparation 2 to give compound(IV-19)

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 3-bromo-1-phenylpropan-1-one (1.5 g, 8.9 mmol), N-phenacyl piperazine dihydrochloride (2.05 g, 7.4 mmol) and K2CO3 (21.75 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-13), 0.64 g (76%), mp 204-205° C., M+ 336. was treated according to the general preparation 2 to give compound (IV-13), 0.64 g (76%), mp 204-205° C., M+ 336

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 2-chloro-1-(4-nitrophenyl)ethanone (3.2 mmol), N-phenacyl piperazine dihydrochloride (3 mmol), and K2CO3 (9 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-11), 0.71 g (61%), mp 204-205° C., M+ 367. was treated according to the general preparation 2 to give compound (IV-11), 0.71 g (61%), mp 204-205° C., M+ 367