No renderable structure data available
CC(C)CCNCChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | N,3-dimethylbutan-1-amine |
|---|---|
| IUPAC Name | — |
| CAS Number | 4104-44-3 |
| Database ID | 521020 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
N,3-dimethylbutan-1-amine (CAS 4104-44-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 521020
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-bc34db0200f9473ba1cded193b585821Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7f60abc63615429d8b0071d6f2d210adConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-648b8ca0ddf343cbada6072908c54140Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To methyl 3-(hydroxymethyl)-5-methylbenzoate prepared by the method in EXAMPLE SP-198, Step 2 in anhydrous methylene chloride at −30° C. is added methanesulfonyl chloride (601 μL, 7.8 mmol), then triethylamine (1.5 mL, 11.1 mmol), and the reaction is stirred at 0° C. 15 min. The resulting precipitate is filtered, and the filtrate is added to N-methylisoamylamine (2.1 mL, 16.7 mmol). The reaction stirred at room temperature 16 h. The solution is concentrated under reduced pressure, redissolved in ethyl acetate and washed with saturated sodium bicarbonate, brine, dried (sodium sulfate), filtered, and concentrated under reduced pressure. Purification by flash column chromatography (silica, 20% ethyl acetate/hexanes) provides the title compound. ESI MS m/z 264.2 [M+H]+. 15 min The resulting precipitate is filtered The solution is concentrated under reduced pressure redissolved in ethyl acetate washed with saturated sodium bicarbonate, brine dried (sodium sulfate) filtered concentrated under reduced pressure Purification by flash column chromatography (silica, 20% ethyl acetate/hexanes)
Source ID: ord-b8e6fb4a9c3d41e9be0fa9a622b67128Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Following Example 216, to a well stirred solution of 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid and N,3-dimethylbutan-1-amine to give 255. MS: (ESI+)=397.1
Source ID: ord-715088a124f04a10b4cfee3a3ec4bb9aConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To methyl 3-(hydroxymethyl)-5-methylbenzoate prepared by the method in EXAMPLE SP-198, Step 2 in anhydrous methylene chloride at −30° C. is added methanesulfonyl chloride (601 μL, 7.8 mmol), then triethylamine (1.5 mL, 11.1 mmol), and the reaction is stirred at 0° C. 15 min. The resulting precipitate is filtered, and the filtrate is added to N-methylisoamylamine (2.1 mL, 16.7 mmol). The reaction stirred at room temperature 16 h. The solution is concentrated under reduced pressure, redissolved in ethyl acetate and washed with saturated sodium bicarbonate, brine, dried (sodium sulfate), filtered, and concentrated under reduced pressure. Purification by flash column chromatography (silica, 20% ethyl acetate/hexanes) provides the title compound. ESI MS m/z 264.2 [M+H]+. 15 min The resulting precipitate is filtered The solution is concentrated under reduced pressure redissolved in ethyl acetate washed with saturated sodium bicarbonate, brine dried (sodium sulfate) filtered concentrated under reduced pressure Purification by flash column chromatography (silica, 20% ethyl acetate/hexanes)
Source ID: ord-b8e6fb4a9c3d41e9be0fa9a622b67128Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To methyl 3-(hydroxymethyl)-5-methylbenzoate prepared by the method in Example SP-198, Step 2 in anhydrous methylene chloride at −30° C. is added methanesulfonyl chloride (601 μL, 7.8 mmol), then triethylamine (1.5 mL, 11.1 mmol), and the reaction is stirred at 0° C. 15 min. The resulting precipitate is filtered, and the filtrate is added to N-methylisoamylamine (2.1 mL, 16.7 mmol). The reaction stirred at room temperature 16 h. The solution is concentrated under reduced pressure, redissolved in ethyl acetate and washed with saturated sodium bicarbonate, brine, dried (sodium sulfate), filtered, and concentrated under reduced pressure. Purification by flash column chromatography (silica, 20% ethyl acetate/hexanes) provides the title compound. ESI MS m/z 264.2 [M+H]+. 15 min The resulting precipitate is filtered The solution is concentrated under reduced pressure redissolved in ethyl acetate washed with saturated sodium bicarbonate, brine dried (sodium sulfate) filtered concentrated under reduced pressure Purification by flash column chromatography (silica, 20% ethyl acetate/hexanes)
Source ID: ord-00113c35734347b0be9a174aae6a904fConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-bc34db0200f9473ba1cded193b585821Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7f60abc63615429d8b0071d6f2d210adConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-648b8ca0ddf343cbada6072908c54140Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To methyl 3-(hydroxymethyl)-5-methylbenzoate prepared by the method in Example SP-198, Step 2 in anhydrous methylene chloride at −30° C. is added methanesulfonyl chloride (601 μL, 7.8 mmol), then triethylamine (1.5 mL, 11.1 mmol), and the reaction is stirred at 0° C. 15 min. The resulting precipitate is filtered, and the filtrate is added to N-methylisoamylamine (2.1 mL, 16.7 mmol). The reaction stirred at room temperature 16 h. The solution is concentrated under reduced pressure, redissolved in ethyl acetate and washed with saturated sodium bicarbonate, brine, dried (sodium sulfate), filtered, and concentrated under reduced pressure. Purification by flash column chromatography (silica, 20% ethyl acetate/hexanes) provides the title compound. ESI MS m/z 264.2 [M+H]+. 15 min The resulting precipitate is filtered The solution is concentrated under reduced pressure redissolved in ethyl acetate washed with saturated sodium bicarbonate, brine dried (sodium sulfate) filtered concentrated under reduced pressure Purification by flash column chromatography (silica, 20% ethyl acetate/hexanes)
Source ID: ord-00113c35734347b0be9a174aae6a904fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Following Example 216, to a well stirred solution of 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid and N,3-dimethylbutan-1-amine to give 255. MS: (ESI+)=397.1
Source ID: ord-86ba030eb2a8419c862b13ae836f85dePubChem References
These sources are listed in the compound's public database record.
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