No renderable structure data available
CCOCC(C(=O)OCC)C(=O)OCCChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | diethyl 2-(ethoxymethyl)propanedioate |
|---|---|
| IUPAC Name | — |
| CAS Number | 40516-46-9 |
| Database ID | 98702 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
diethyl 2-(ethoxymethyl)propanedioate (CAS 40516-46-9) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 98702
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-6724102c04b0410f8ca658a0b4ff4881Conditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under a nitrogen atmosphere, a mixture of 3-(trifluoromethyl)aniline (40 mL, 0.32 mmol) and diethyl ethoxymethylmalonate was heated at 100° C. for 3 hours. The reaction mixture was allowed to cool to room temperature at which time the solution solidified to provide 102 g of diethyl 2-{[3-(trifluoromethyl)anilino]methylene}malonate as a cream colored solid. to cool to room temperature at which time the solution
Source ID: ord-687c605da28247fe8d3981cf472964faConditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under a nitrogen atmosphere, 3-fluoroaniline (50.0 g, 0.45 mol) and diethyl ethoxymethylmalonate (91 mL, 0.45 mol) were combined and heated at 100° C. for 3 hours. The reaction was allowed to cool to ambient temperature and it solidified. Dowtherm A (200 mL) was added and the reaction mixture was heated at 240° C. for 4 hours. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, washed with hexane and then dried in a vacuum oven to provide 71.5 g of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate. to cool to ambient temperature the reaction mixture was heated at 240° C. for 4 hours to cool to ambient temperature The resulting precipitate was isolated by filtration washed with hexane dried in a vacuum oven
Source ID: ord-634289ea48ee4766bd160165ae5e52f6Conditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl ethoxymethylmalonate (37.8 mL, 187 mmol) and m-toluidine (20.0 mL, 187 mmol) were combined and heated at 100° C. for about 3 hours. The reaction mixture was allowed to cool to ambient temperature and it solidified. Dowtherm A (350 mL) was added and the reaction mixture was heated at reflux for about 30 minutes. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed with acetone and dried to provide 33 g of ethyl 4-hydroxy-7-methyl-3-quinolinecarboxylate as a tan powder. to cool to ambient temperature the reaction mixture was heated at reflux for about 30 minutes to cool to ambient temperature The resulting precipitate was isolated by filtration rinsed with acetone dried
Source ID: ord-409dc54188c142688eb537344e936c84Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-6724102c04b0410f8ca658a0b4ff4881Conditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under a nitrogen atmosphere, a mixture of 3-(trifluoromethyl)aniline (40 mL, 0.32 mmol) and diethyl ethoxymethylmalonate was heated at 100° C. for 3 hours. The reaction mixture was allowed to cool to room temperature at which time the solution solidified to provide 102 g of diethyl 2-{[3-(trifluoromethyl)anilino]methylene}malonate as a cream colored solid. to cool to room temperature at which time the solution
Source ID: ord-fb836fd4fedd4b40abbb7dd8be368e52Conditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under a nitrogen atmosphere, 3-fluoroaniline (50.0 g, 0.45 mol) and diethyl ethoxymethylmalonate (91 mL, 0.45 mol) were combined and heated at 100° C. for 3 hours. The reaction was allowed to cool to ambient temperature and it solidified. Dowtherm A (200 mL) was added and the reaction mixture was heated at 240° C. for 4 hours. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, washed with hexane and then dried in a vacuum oven to provide 71.5 g of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate. to cool to ambient temperature the reaction mixture was heated at 240° C. for 4 hours to cool to ambient temperature The resulting precipitate was isolated by filtration washed with hexane dried in a vacuum oven
Source ID: ord-3856652e2ed9497bbeddf530f82620bfConditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl ethoxymethylmalonate (37.8 mL, 187 mmol) and m-toluidine (20.0 mL, 187 mmol) were combined and heated at 100° C. for about 3 hours. The reaction mixture was allowed to cool to ambient temperature and it solidified. Dowtherm A (350 mL) was added and the reaction mixture was heated at reflux for about 30 minutes. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed with acetone and dried to provide 33 g of ethyl 4-hydroxy-7-methyl-3-quinolinecarboxylate as a tan powder. to cool to ambient temperature the reaction mixture was heated at reflux for about 30 minutes to cool to ambient temperature The resulting precipitate was isolated by filtration rinsed with acetone dried
Source ID: ord-fb36f1b3add34ba89cd9a80ac1fab674Conditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl ethoxymethylmalonate (37.8 mL, 187 mmol) and m-toluidine (20.0 mL, 187 mmol) were combined and heated at 100° C. for about 3 hours. The reaction mixture was allowed to cool to ambient temperature and it solidified. Dowtherm A (350 mL) was added and the reaction mixture was heated at reflux for about 30 minutes. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed with acetone and dried to provide 33 g of ethyl 4-hydroxy-7-methyl-3-quinolinecarboxylate as a tan powder. to cool to ambient temperature the reaction mixture was heated at reflux for about 30 minutes to cool to ambient temperature The resulting precipitate was isolated by filtration rinsed with acetone dried
Source ID: ord-fb36f1b3add34ba89cd9a80ac1fab674Conditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: under a nitrogen atmosphere, 3-fluoroaniline (50.0 g, 0.45 mol) and diethyl ethoxymethylmalonate (91 mL, 0.45 mol) were combined and heated at 100° C. for 3 hours. The reaction was allowed to cool to ambient temperature and it solidified. Dowtherm A (200 mL) was added and the reaction mixture was heated at 240° C. for 4 hours. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, washed with hexane and then dried in a vacuum oven to provide 71.5 g of ethyl 7-fluoro-4-hydroxy-3-quinolinecarboxylate. to cool to ambient temperature the reaction mixture was heated at 240° C. for 4 hours to cool to ambient temperature The resulting precipitate was isolated by filtration washed with hexane dried in a vacuum oven
Source ID: ord-7577e2c8c88a4fd8a342bc19ecff852aConditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl ethoxymethylmalonate (37.8 mL, 187 mmol) and m-toluidine (20.0 mL, 187 mmol) were combined and heated at 100° C. for about 3 hours. The reaction mixture was allowed to cool to ambient temperature and it solidified. Dowtherm A (350 mL) was added and the reaction mixture was heated at reflux for about 30 minutes. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed with acetone and dried to provide 33 g of ethyl 4-hydroxy-7-methyl-3-quinolinecarboxylate as a tan powder. to cool to ambient temperature the reaction mixture was heated at reflux for about 30 minutes to cool to ambient temperature The resulting precipitate was isolated by filtration rinsed with acetone dried
Source ID: ord-1ea39f341a784220968943198e07225eConditions: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Diethyl ethoxymethylmalonate (37.8 mL, 187 mmol) and m-toluidine (20.0 mL, 187 mmol) were combined and heated at 100° C. for about 3 hours. The reaction mixture was allowed to cool to ambient temperature and it solidified. Dowtherm A (350 mL) was added and the reaction mixture was heated at reflux for about 30 minutes. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed with acetone and dried to provide 33 g of ethyl 4-hydroxy-7-methyl-3-quinolinecarboxylate as a tan powder. to cool to ambient temperature the reaction mixture was heated at reflux for about 30 minutes to cool to ambient temperature The resulting precipitate was isolated by filtration rinsed with acetone dried
Source ID: ord-1ea39f341a784220968943198e07225ePubChem References
These sources are listed in the compound's public database record.
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