No renderable structure data available
CCSC(=O)C(F)(F)FChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | S-ethyl 2,2,2-trifluoroethanethioate |
|---|---|
| IUPAC Name | — |
| CAS Number | 383-64-2 |
| Database ID | 67844 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
S-ethyl 2,2,2-trifluoroethanethioate (CAS 383-64-2) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 67844
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
10 reactions · 10 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-02034b8d77c84d96977140f4e1d29a1bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a suspension of 2′-amino,2′-deoxyuridine (2.0 g, 8.22 mmoles) in methanol (150 ml) was added S-ethyl trifluorothioacetate (1.6 ml, 12.48 mmoles, 1.5 eq.). This mixture was stirred at room temperature overnight. Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts. The mixture was evaporated to dryness and the solid was recrystallized from methanol/chloroform to yield 2.3 g (82%) of 2′-trifluoroacetylamino,2′-deoxyuridine. The analytical data agreed with the literature (Imazawa and Eckstein (1979) supra). Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts The mixture was evaporated to dryness the solid was recrystallized from methanol/chloroform
Source ID: ord-58ba2e4514ad44fda312e989e40ae450Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a suspension of 2'-amino,2'-deoxyuridine (2.0 g, 8.22 mmoles) in methanol (150 ml) was added S-ethyl trifluorothioacetate (1.6 ml, 12.48 mmoles, 1.5 eq.). This mixture was stirred at room temperature overnight. Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts. The mixture was evaporated to dryness and the solid was recrystallized from methanol/chloroform to yield 2.3 g (82%) of 2'-trifluoroacetylamino,2'-deoxyuridine. The analytical data agreed with the literature (Imazawa and Eckstein (1979) supra). Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts The mixture was evaporated to dryness the solid was recrystallized from methanol/chloroform
Source ID: ord-db3d002fe52248e1abf38595c0e24f37Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a suspension of 2'-amino,2'-deoxyuridine (2.0 g, 8.22 mmoles) in methanol (150 ml) was added S-ethyl trifluorothioacetate (1.6 ml, 12.48 mmoles, 1.5 eq.). This mixture was stirred at room temperature overnight. Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts. The mixture was evaporated to dryness and the solid was recrystallized from methanol/chloroform to yield 2.3 g (82%) of 2'-trifluoroacetylamino,2'-deoxyuridine. The analytical data agreed with the literature (Imazawa and Eckstein (1979) supra). Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts The mixture was evaporated to dryness the solid was recrystallized from methanol/chloroform
Source ID: ord-db3d002fe52248e1abf38595c0e24f37Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-02034b8d77c84d96977140f4e1d29a1bConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a suspension of 2′-amino,2′-deoxyuridine (2.0 g, 8.22 mmoles) in methanol (150 ml) was added S-ethyl trifluorothioacetate (1.6 ml, 12.48 mmoles, 1.5 eq.). This mixture was stirred at room temperature overnight. Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts. The mixture was evaporated to dryness and the solid was recrystallized from methanol/chloroform to yield 2.3 g (82%) of 2′-trifluoroacetylamino,2′-deoxyuridine. The analytical data agreed with the literature (Imazawa and Eckstein (1979) supra). Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts The mixture was evaporated to dryness the solid was recrystallized from methanol/chloroform
Source ID: ord-58ba2e4514ad44fda312e989e40ae450Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a suspension of 2'-amino,2'-deoxyuridine (2.0 g, 8.22 mmoles) in methanol (150 ml) was added S-ethyl trifluorothioacetate (1.6 ml, 12.48 mmoles, 1.5 eq.). This mixture was stirred at room temperature overnight. Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts. The mixture was evaporated to dryness and the solid was recrystallized from methanol/chloroform to yield 2.3 g (82%) of 2'-trifluoroacetylamino, 2'-deoxyuridine. The analytical data agreed with the literature (Imazawa and Eckstein (1979) supra). Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts The mixture was evaporated to dryness the solid was recrystallized from methanol/chloroform
Source ID: ord-fd6c4cb344a24c5e9a81abadae4fd274Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a suspension of 2'-amino,2'-deoxyuridine (2.0 g, 8.22 mmoles) in methanol (150 ml) was added S-ethyl trifluorothioacetate (1.6 ml, 12.48 mmoles, 1.5 eq.). This mixture was stirred at room temperature overnight. Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts. The mixture was evaporated to dryness and the solid was recrystallized from methanol/chloroform to yield 2.3 g (82%) of 2'-trifluoroacetylamino, 2'-deoxyuridine. The analytical data agreed with the literature (Imazawa and Eckstein (1979) supra). Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts The mixture was evaporated to dryness the solid was recrystallized from methanol/chloroform
Source ID: ord-fd6c4cb344a24c5e9a81abadae4fd274Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Ethanolamine (12 g) is dissolved in methanol (50 ml) and S-ethylthiotrifluoroacetate (35 g) is added dropwise. The reaction is permitted to stand overnight irrigated with a stream of argon to remove ethanethiol. The excess solvent is removed in vacuo to leave the title product. to remove ethanethiol The excess solvent is removed in vacuo
Source ID: ord-081d54460a784969b6ff6bd41a780154Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a suspension of 2'-amino,2'-deoxyuridine (2.0 g, 8.22 mmoles) in methanol (150 ml) was added S-ethyl trifluorothioacetate (1.6 ml, 12.48 mmoles, 1.5 eq.). This mixture was stirred at room temperature overnight. Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts. The mixture was evaporated to dryness and the solid was recrystallized from methanol/chloroform to yield 2.3 g (82%) of 2'-trifluoroacetylamino,2'-deoxyuridine. The analytical data agreed with the literature (Imazawa and Eckstein (1979) supra). Nitrogen was bubbled through the reaction mixture for 2 h to remove volatile thio-byproducts The mixture was evaporated to dryness the solid was recrystallized from methanol/chloroform
Source ID: ord-db3d002fe52248e1abf38595c0e24f37PubChem References
These sources are listed in the compound's public database record.
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