No renderable structure data available
C(C#N)S(=O)(=O)CC#NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 2-(cyanomethylsulfonyl)acetonitrile |
|---|---|
| IUPAC Name | — |
| CAS Number | 37463-94-8 |
| Database ID | 142163 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
2-(cyanomethylsulfonyl)acetonitrile (CAS 37463-94-8) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 142163
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-89e4f7bad4534f3f85c306aef26a7407Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: M36 was prepared with 3,5-di-t-butyl-4-hydroxybenzaldehyde and sulfonyl diacetonitrile under similar conditions as described for M27.
Source ID: ord-77d19ad75c304fcca1e3317e67681e55Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of (0.5 g) of 2-nitrothiophen-5-carboxaldehyde and (0.7 g) of sulfonyl diacetonitrile in 6 mL ethanol was refluxed with a few drops of piperidine for 4 hours. Ethanol was removed in a rotavap and the mixture worked up with ethylacetate, diluted acid and brine. A portion of the crude was then purified by HPLC on a C-18 column to provide (0.05 g) of (E)-2-cyanomethylsulfonyl-3-(2-nitrothien-5-yl)acrylonitrile along with (0.03 g) of (E,E)-2-[[1-cyano-2-(2-nitrothien-5-yl)ethenyl]sulfonyl]-3-(2-nitrothien-5-yl)acrylonitrile. Ethanol was removed in a rotavap diluted acid and brine A portion of the crude was then purified by HPLC on a C-18 column
Source ID: ord-3dcc6fd963ca4a3b83425bf6b2ba5022Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 500 mg of 5-bromo-3,4-dihydroxybenzaldehyde and 700 mg of sulfonly diacetonitrile in 6 ml of ethanol was refluxed with few drops of piperidine for 4 hours. Ethanol was removed in rotavap and the mixture worked up with ethyl acetate, diluted acid and brine. A portion of the crude was then purified by HPLC on a C-18 column to provide about 50 mg of 2-(3-bromo-4,5-dihydroxyphenyl)-1-cyano-1-cyanomethylsulfonly ethene. Ethanol was removed in rotavap diluted acid and brine A portion of the crude was then purified by HPLC on a C-18 column
Source ID: ord-7ce82f49b6b4482482eee56e659a480cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 500 mg of 5-bromo-3,4-dihydroxybenzaldehyde and 700 mg of sulfonly diacetonitrile in 6 ml of ethanol was refluxed with few drops of piperidine for 4 hours. Ethanol was removed in rotavap and the mixture worked up with ethyl acetate, diluted acid and brine. A portion of the crude was then purified by HPLC on a C-18 column to provide about 50 mg of 2-(3-bromo-4,5-dihydroxyphenyl)-1-cyano-1-cyanomethylsulfonly ethene. Ethanol was removed in rotavap diluted acid and brine A portion of the crude was then purified by HPLC on a C-18 column
Source ID: ord-7ce82f49b6b4482482eee56e659a480cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: M36 was prepared with 3,5-di-t-butyl-4-hydroxybenzaldehyde and sulfonyl diacetonitrile under similar conditions as described for M27.
Source ID: ord-cc7cefdcfa9f438595b9ec6beded5e12Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The titled compound was prepared with 3,5-di-t-butyl-4-hydroxybenzaldehyde and sulphonyl diacetonitrile under the similar condition as described for EXAMPLE 2.
Source ID: ord-735da5ea5dc04295a1ee10a7e57d81d9Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The titled compound was prepared with 3,5-di-t-butyl-4-hydroxybenzaldehyde and sulphonyl diacetonitrile under the similar condition as described for EXAMPLE 2.
Source ID: ord-735da5ea5dc04295a1ee10a7e57d81d9Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 500 mg of 3,5-diisopropyl-4-hydroxybenzaldehyde and 700 mg of sulphonyl diacetonitrile in 6 ml of ethanol was refluxed with a few drops of piperidine for 4 hours. Ethanol was removed in a rotavap and the mixture worked up with ethyl acetate, diluted acid and brine. A portion of the crude was then purified by HPLC on a C-18 column to provide 50 mg of the titled compound along with 30 mg of (E,E)-2-[[1--Cyano-2-(3,5-diisopropyl-4-hydroxyphenyl)ethenyl]sulfonyl]-3-(3,5-diisopropyl-4-hydroxyphenyl)acrylonitrile. Ethanol was removed in a rotavap diluted acid and brine A portion of the crude was then purified by HPLC on a C-18 column
Source ID: ord-176c1636fb854f6b8b17c03e7c09027cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 500 mg of 3,5-diisopropyl-4-hydroxybenzaldehyde and 700 mg of sulphonyl diacetonitrile in 6 ml of ethanol was refluxed with a few drops of piperidine for 4 hours. Ethanol was removed in a rotavap and the mixture worked up with ethyl acetate, diluted acid and brine. A portion of the crude was then purified by HPLC on a C-18 column to provide 50 mg of the titled compound along with 30 mg of (E,E)-2-[[1--Cyano-2-(3,5-diisopropyl-4-hydroxyphenyl)ethenyl]sulfonyl]-3-(3,5-diisopropyl-4-hydroxyphenyl)acrylonitrile. Ethanol was removed in a rotavap diluted acid and brine A portion of the crude was then purified by HPLC on a C-18 column
Source ID: ord-176c1636fb854f6b8b17c03e7c09027cConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-89e4f7bad4534f3f85c306aef26a7407Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture of 500 mg of 5-bromo-3,4-dihydroxybenzaldehyde and 700 mg of sulfonly diacetonitrile in 6 ml of ethanol was refluxed with few drops of piperidine for 4 hours. Ethanol was removed in rotavap and the mixture worked up with ethyl acetate, diluted acid and brine. A portion of the crude was then purified by HPLC on a C-18 column to provide about 50 mg of 2-(3-bromo-4,5-dihydroxyphenyl)-1-cyano-1-cyanomethylsulfonly ethene. Ethanol was removed in rotavap diluted acid and brine A portion of the crude was then purified by HPLC on a C-18 column
Source ID: ord-1eada25f5d8c4f7891652911b3ea19fcPubChem References
These sources are listed in the compound's public database record.
Request a Quote
Send the required specification, quantity, destination and intended use. The CATO team will review availability and respond.