N,N-diethyl-1,3,2-dioxaphospholan-2-amine

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 2.72 g (10 mmol) of 7-aminocephalosporanic acid are suspended in 50 ml of dry methylene chloride. 1.5 ml (10 mmol) of 2-diethylamino-1,3,2-dioxaphospholane and 1.33 ml (10.5 mmol) of trimethylchlorosilane are added under nitrogen at room temperature. The reaction mixture is stirred for 16 hours at room temperature. After cooling to 0° C, a solution of 10 mmol of cyanoacetyl chloride in 6 ml of methylene chloride is added over 5 minutes. After cooling to 0° C