No renderable structure data available
CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)OChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol |
|---|---|
| IUPAC Name | — |
| CAS Number | 37148-27-9 |
| Database ID | 2783 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol (CAS 37148-27-9) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 2783
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-e6ad6b8a0d1c48b7865f3a36fb9d50edConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-e6ad6b8a0d1c48b7865f3a36fb9d50edConditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture containing 2.5 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol, 25 ml of pyridine and 10 ml of acetic anhydride is stirred for three hours and evaporated to dryness in vacuo with heating up to 70° C. The residue is treated with ice, 100 ml of CH2Cl2 and 50 ml of 10% NaOH solution. evaporated to dryness in vacuo The residue is treated with ice, 100 ml of CH2Cl2 and 50 ml of 10% NaOH solution
Source ID: ord-37a2333456014414a5d8b2539a315087Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture containing 2.5 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol, 25 ml of pyridine and 10 ml of acetic anhydride is stirred for three hours and evaporated to dryness in vacuo with heating up to 70° C. The residue is treated with ice, 100 ml of CH2Cl2 and 50 ml of 10% NaOH solution. evaporated to dryness in vacuo The residue is treated with ice, 100 ml of CH2Cl2 and 50 ml of 10% NaOH solution
Source ID: ord-37a2333456014414a5d8b2539a315087Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In 100 ml of methanol, 10 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol is stirred in an ice bath and dry HCl gas is introduced into the solution. After saturation of the solution, the mixture is stirred at room temperature for an hour and evaporated to dryness. The solid is then stirred in ethyl acetate to afford the title product, which is collected by filtration. evaporated to dryness The solid is then stirred in ethyl acetate
Source ID: ord-f8522215ba9544db853a56e238956a86Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In 100 ml of methanol, 10 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol is stirred in an ice bath and dry HCl gas is introduced into the solution. After saturation of the solution, the mixture is stirred at room temperature for an hour and evaporated to dryness. The solid is then stirred in ethyl acetate to afford the title product, which is collected by filtration. evaporated to dryness The solid is then stirred in ethyl acetate
Source ID: ord-f8522215ba9544db853a56e238956a86Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Under N2 atmosphere, 27.72 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol is added to 200 ml of thionyl chloride stirred at 0°-5° C. After addition is completed, the reaction mixture is stirred at ambient temperature for 3 hours. Subsequently, the mixture is evaporated to dryness in vacuo to afford 37.34 g of yellow solid, which is used as is. After addition the reaction mixture is stirred at ambient temperature for 3 hours Subsequently, the mixture is evaporated to dryness in vacuo
Source ID: ord-5e4ce97cd8af461fa57d9a276134d822Conditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture containing 2.5 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol, 25 ml of pyridine and 10 ml of acetic anhydride is stirred for three hours and evaporated to dryness in vacuo with heating up to 70° C. The residue is treated with ice, 100 ml of CH2Cl2 and 50 ml of 10% NaOH solution. The CH2Cl2 phase is separated, and the aqueous portion is further extracted with CH2CL2 (2×50 ml). The combined CH2CL2 solutions are dried (Na2SO4) and evaporated to dryness to afford a solid after scratching. The solid is washed with hexane and collected to afford 2.61 g of the title compound, mp 126°-136° C. evaporated to dryness in vacuo The residue is treated with ice, 100 ml of CH2Cl2 and 50 ml of 10% NaOH solution The CH2Cl2 phase is separated the aqueous portion is further extracted with CH2CL2 (2×50 ml) The combined CH2CL2 solutions are dried (Na2SO4) evaporated to dryness to afford a solid The solid is washed with hexane collected
Source ID: ord-14af09672e2b4b7ba6311449c1ea71dbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In 100 ml of methanol, 10 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol is stirred in an ice bath and dry HCl gas is introduced into the solution. After saturation of the solution, the mixture is stirred at room temperature for an hour and evaporated to dryness. The solid is then stirred in ethyl acetate to afford the title product, which is collected by filtration. evaporated to dryness The solid is then stirred in ethyl acetate
Source ID: ord-0c2a1dcc61b341fc9e055d5d4aee1b8aConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In 100 ml of methanol, 10 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol is stirred in an ice bath and dry HCl gas is introduced into the solution. After saturation of the solution, the mixture is stirred at room temperature for an hour and evaporated to dryness. The solid is then stirred in ethyl acetate to afford the title product, which is collected by filtration. evaporated to dryness The solid is then stirred in ethyl acetate
Source ID: ord-0c2a1dcc61b341fc9e055d5d4aee1b8aConditions: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A mixture containing 2.5 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol, 25 ml of pyridine and 10 ml of acetic anhydride is stirred for three hours and evaporated to dryness in vacuo with heating up to 70° C. The residue is treated with ice, 100 ml of CH2Cl2 and 50 ml of 10% NaOH solution. The CH2Cl2 phase is separated, and the aqueous portion is further extracted with CH2CL2 (2×50 ml). The combined CH2CL2 solutions are dried (Na2SO4) and evaporated to dryness to afford a solid after scratching. The solid is washed with hexane and collected to afford 2.61 g of the title compound, mp 126°-136° C. evaporated to dryness in vacuo The residue is treated with ice, 100 ml of CH2Cl2 and 50 ml of 10% NaOH solution The CH2Cl2 phase is separated the aqueous portion is further extracted with CH2CL2 (2×50 ml) The combined CH2CL2 solutions are dried (Na2SO4) evaporated to dryness to afford a solid The solid is washed with hexane collected
Source ID: ord-20846a81c2224bfd880273cd7448e0a2Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: In 100 ml of methanol, 10 g of 4-amino-α-[(tert-butylamino)methyl]-3,5-dichlorobenzyl alcohol is stirred in an ice bath and dry HCl gas is introduced into the solution. After saturation of the solution, the mixture is stirred at room temperature for an hour and evaporated to dryness. The solid is then stirred in ethyl acetate to afford the title product, which is collected by filtration. evaporated to dryness The solid is then stirred in ethyl acetate
Source ID: ord-b6a43ce8581546f399c2eedabee6ce36PubChem References
These sources are listed in the compound's public database record.
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