1,1,3,3-tetrafluoropropan-2-one

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: The procedure of Example 4 is used with 2-amino-methoxybenzene and sym-tetrafluoroacetone to give 4-amino[2,2-difluoro-1-hydroxy-1-(difluoromethyl)ethyl]-3-methoxybenzene.

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: A mixture of 2-amino-hydroxybenzene, toluene and sym-tetrafluoroacetone can be heated in a Hastelloy® bomb. The solvent can be removed by evaporation and the residual material can be purified by chromatography on silica gel to give 4-amino[2,2-difluoro-1-hydroxy-1-(difluoromethyl)ethyl]-3-hydroxybenzene. The solvent can be removed by evaporation the residual material can be purified by chromatography on silica gel