dodecoxybenzene

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Dodecyloxybenzene (2.48 g; 9.45 mmol) is dissolved in N-methylformanilide (195.17 g; 9.45 mmol). POCl3 (1.45 g; 159.33 g; 9.45 mmol) is added dropwise with ice-cooling. Stirring is carried out for 1 hour at 25° C., and then for 3 hours at 60° C. Pouring onto ice is then carried out and the pH is adjusted to 6 using sodium hydroxide solution. Extraction is then carried out with tert-butyl methyl ether (2×50 ml), and the combined organic phases are washed with aqueous NaHCO3 solution and dried over Na2SO4. After filtration, concentration to dryness by evaporation is carried out. cooling for 3 hours at 60° C Pouring onto ice Extraction the combined organic phases are washed with aqueous NaHCO3 solution dried over Na2SO4 After filtration, concentration to dryness by evaporation

Conditions: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Phenol (47 g; 0.5 mol) is dissolved in DMF (300 ml), and K2CO3 (82.93 g; 0.6 mol) is added. 1-Bromododecane (124.6 g; 0.5 mol) is then added dropwise to the solution at 70° C. After a further 15 hours at 80° C., cooling to 25° C. is carried out, followed by dilution with water (500 ml) and extraction with tert-butyl methyl ether (2×250 ml). The combined organic extracts are washed with water (2×250 ml) and dried over Na2SO4. After filtration, concentration to dryness by evaporation is carried out. followed by dilution with water (500 ml) and extraction with tert-butyl methyl ether (2×250 ml) The combined organic extracts are washed with water (2×250 ml) dried over Na2SO4 After filtration, concentration to dryness by evaporation