No renderable structure data available
CCC1=C2C(=CC(=C1)Br)C(=O)C(=O)N2Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 5-bromo-7-ethyl-1H-indole-2,3-dione |
|---|---|
| IUPAC Name | — |
| CAS Number | 34921-60-3 |
| Database ID | 8033813 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
5-bromo-7-ethyl-1H-indole-2,3-dione (CAS 34921-60-3) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 8033813
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-5023a92e3bd8408f810fcdd5f0b7671aConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-5023a92e3bd8408f810fcdd5f0b7671aConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-5023a92e3bd8408f810fcdd5f0b7671aConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Following the procedure of example 36.B. except using N-(4-Bromo-2-ethyl-phenyl)-2-hydroxyimino-acetamide as the acetamide component afforded the title compound as a solid. ESI (−) MS m/e=252 (MH−).
Source ID: ord-8bb24b8c0c7a4715bec27885249914e8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Following the procedure of example 36.B. except using N-(4-Bromo-2-ethyl-phenyl)-2-hydroxyimino-acetamide as the acetamide component afforded the title compound as a solid. ESI (−) MS m/e=252 (MH−).
Source ID: ord-8bb24b8c0c7a4715bec27885249914e8Conditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 5-bromo-7-ethyl-1H-indole-2,3-dione (36.g, 144 mmol) in tetrahydrofuran (120 mL) at room temperature was dropped a 2.0 M solution of lithium borohydride in tetrahydrofuran. The reaction mixture was stirred at 90° C. (oil bath) for 5 hours. After cooling down to room temperature, it was quenched with 5% hydrochloric acid solution until the excess lithium borohydride was destroyed. To the mixture was added saturated sodium bicarbonate solution (300 mL) and extracted with ethyl acetate. Extracts were dried over magnesium sulfate and concentrated under reduced pressure to give the crude product of 5-bromo-7-ethyl-1H-indole, which went to next reaction without further purification. After cooling down to room temperature it was quenched with 5% hydrochloric acid solution until the excess lithium borohydride was destroyed To the mixture was added saturated sodium bicarbonate solution (300 mL) extracted with ethyl acetate Extracts were dried over magnesium sulfate concentrated under reduced pressure
Source ID: ord-2f4bbbd98ec54a318d290e8cac149fe1Conditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 5-bromo-7-ethyl-1H-indole-2,3-dione (36.g, 144 mmol) in tetrahydrofuran (120 mL) at room temperature was dropped a 2.0 M solution of lithium borohydride in tetrahydrofuran. The reaction mixture was stirred at 90° C. (oil bath) for 5 hours. After cooling down to room temperature, it was quenched with 5% hydrochloric acid solution until the excess lithium borohydride was destroyed. To the mixture was added saturated sodium bicarbonate solution (300 mL) and extracted with ethyl acetate. Extracts were dried over magnesium sulfate and concentrated under reduced pressure to give the crude product of 5-bromo-7-ethyl-1H-indole, which went to next reaction without further purification. After cooling down to room temperature it was quenched with 5% hydrochloric acid solution until the excess lithium borohydride was destroyed To the mixture was added saturated sodium bicarbonate solution (300 mL) extracted with ethyl acetate Extracts were dried over magnesium sulfate concentrated under reduced pressure
Source ID: ord-2f4bbbd98ec54a318d290e8cac149fe1Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of sulfuric acid (100 mL) and water (10 mL) at 80° C. (oil bath) was added N-(4-bromo-2-ethyl-phenyl)-2-hydroximino-acetoamide (61.0 g, 225 mmol) in small portions over 20 minutes. The reaction mixture was heated at 80° C. (oil bath) for 15 minutes. After cooling to room temperature, ice-water (500 mL) was added and the mixture was extracted with ethyl acetate. Extracts were washed with saturated sodium bicarbonate solution, dried over magnesium sulfate, and concentrated under reduced pressure to give the title compound (42.3 g, 74% yield). 1H NMR (DMSO-d6) δ 8.87 (s, 1H), 7.75 (d, 1H), 7.71 (d, 1H), 2.75 (q, 2H), 1.44 (t, 3H). After cooling to room temperature the mixture was extracted with ethyl acetate Extracts were washed with saturated sodium bicarbonate solution dried over magnesium sulfate concentrated under reduced pressure
Source ID: ord-ea8eaf21ef8e48909001cf7deaafa623Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of sulfuric acid (100 mL) and water (10 mL) at 80° C. (oil bath) was added N-(4-bromo-2-ethyl-phenyl)-2-hydroximino-acetoamide (61.0 g, 225 mmol) in small portions over 20 minutes. The reaction mixture was heated at 80° C. (oil bath) for 15 minutes. After cooling to room temperature, ice-water (500 mL) was added and the mixture was extracted with ethyl acetate. Extracts were washed with saturated sodium bicarbonate solution, dried over magnesium sulfate, and concentrated under reduced pressure to give the title compound (42.3 g, 74% yield). 1H NMR (DMSO-d6) δ 8.87 (s, 1H), 7.75 (d, 1H), 7.71 (d, 1H), 2.75 (q, 2H), 1.44 (t, 3H). After cooling to room temperature the mixture was extracted with ethyl acetate Extracts were washed with saturated sodium bicarbonate solution dried over magnesium sulfate concentrated under reduced pressure
Source ID: ord-ea8eaf21ef8e48909001cf7deaafa623Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Following the procedure of example 36.B. except using N-(4-Bromo-2-ethyl-phenyl)-2-hydroxyimino-acetamide as the acetamide component afforded the title compound as a solid. ESI (−) MS m/e=252 (MH−).
Source ID: ord-8bb24b8c0c7a4715bec27885249914e8Conditions: temp:90.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 5-bromo-7-ethyl-1H-indole-2,3-dione (36.g, 144 mmol) in tetrahydrofuran (120 mL) at room temperature was dropped a 2.0 M solution of lithium borohydride in tetrahydrofuran. The reaction mixture was stirred at 90° C. (oil bath) for 5 hours. After cooling down to room temperature, it was quenched with 5% hydrochloric acid solution until the excess lithium borohydride was destroyed. To the mixture was added saturated sodium bicarbonate solution (300 mL) and extracted with ethyl acetate. Extracts were dried over magnesium sulfate and concentrated under reduced pressure to give the crude product of 5-bromo-7-ethyl-1H-indole, which went to next reaction without further purification. After cooling down to room temperature it was quenched with 5% hydrochloric acid solution until the excess lithium borohydride was destroyed To the mixture was added saturated sodium bicarbonate solution (300 mL) extracted with ethyl acetate Extracts were dried over magnesium sulfate concentrated under reduced pressure
Source ID: ord-2f4bbbd98ec54a318d290e8cac149fe1Conditions: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of sulfuric acid (100 mL) and water (10 mL) at 80° C. (oil bath) was added N-(4-bromo-2-ethyl-phenyl)-2-hydroximino-acetoamide (61.0 g, 225 mmol) in small portions over 20 minutes. The reaction mixture was heated at 80° C. (oil bath) for 15 minutes. After cooling to room temperature, ice-water (500 mL) was added and the mixture was extracted with ethyl acetate. Extracts were washed with saturated sodium bicarbonate solution, dried over magnesium sulfate, and concentrated under reduced pressure to give the title compound (42.3 g, 74% yield). 1H NMR (DMSO-d6) δ 8.87 (s, 1H), 7.75 (d, 1H), 7.71 (d, 1H), 2.75 (q, 2H), 1.44 (t, 3H). After cooling to room temperature the mixture was extracted with ethyl acetate Extracts were washed with saturated sodium bicarbonate solution dried over magnesium sulfate concentrated under reduced pressure
Source ID: ord-ea8eaf21ef8e48909001cf7deaafa623PubChem References
These sources are listed in the compound's public database record.
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