1-chloro-3-(3,4-dimethoxyphenyl)propan-2-one

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: To the solution of 1,2-dimethoxybenzene (0.05 mol) dissolved in dichloromethane (30 mL), AlCl3 (0.10 mol) is added batch by batch and 3-chloropropionyl chloride (0.055 mol) is added dropwise, while the internal temperature is maintained below 5° C. Following procedures described in General Method One-Method A, 3-chloro-1-(3,4-dimethoxyphenyl)-propanone is obtained as a white solid (10.3 g). The yield is 90.0%. MS(m/z): 229.0 [M+1]+. is added dropwise, while the internal temperature is maintained below 5° C