No renderable structure data available
C1=CC=C2C(=C1)C(=O)N(C2=O)CCCCCC(=O)ClChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 6-(1,3-dioxoisoindol-2-yl)hexanoyl chloride |
|---|---|
| IUPAC Name | — |
| CAS Number | 31968-60-2 |
| Database ID | 594868 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
6-(1,3-dioxoisoindol-2-yl)hexanoyl chloride (CAS 31968-60-2) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 594868
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b5b5629ec56f43a387e66a22594c5b3fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 6-phthalimidohexanoyl chloride (2 g.) in dry toluene was added to an ethereal solution of diazoethane at -78° C. and the mixture was allowed to warm to room temperature and stand for 15 hours. On standing a solid crystallized out of solution. The reaction mixture was filtered and the filtrate evaporated to dryness giving 1.43 g. of yellow-green oil. This oil was then dissolved in acetone and concentrated hydrochloric acid added until effervescence ceased. The resulting yellow-brown solution was then evaporated to dryness and azeotroped three times with toluene to give N-(7-chloro-6-oxooctyl)phthalimide (1.4 g.) which was used without further purification. crystallized out of solution The reaction mixture was filtered the filtrate evaporated to dryness giving 1.43 g The resulting yellow-brown solution was then evaporated to dryness azeotroped three times with toluene
Source ID: ord-a29164592f604bc480bf82c469987066Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 6-phthalimidohexanoyl chloride (2 g.) in dry toluene was added to an ethereal solution of diazoethane at -78° C. and the mixture was allowed to warm to room temperature and stand for 15 hours. On standing a solid crystallized out of solution. The reaction mixture was filtered and the filtrate evaporated to dryness giving 1.43 g. of yellow-green oil. This oil was then dissolved in acetone and concentrated hydrochloric acid added until effervescence ceased. The resulting yellow-brown solution was then evaporated to dryness and azeotroped three times with toluene to give N-(7-chloro-6-oxooctyl)phthalimide (1.4 g.) which was used without further purification. crystallized out of solution The reaction mixture was filtered the filtrate evaporated to dryness giving 1.43 g The resulting yellow-brown solution was then evaporated to dryness azeotroped three times with toluene
Source ID: ord-a29164592f604bc480bf82c469987066Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The same procedure is used as for Compound I, using 2,4,6-triiodo-3-amino-benzoic acid as iodo starting marterial and ε-phthalimidocaproic acid chloride.
Source ID: ord-757ded56c3264e91905eb10f6c3901b8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The same procedure is used as for Compound I, using 2,4,6-triiodo-3-amino-benzoic acid as iodo starting material and ε-phthalimidocaproic acid chloride.
Source ID: ord-ad7086829c9f480dabc1dbe902240a24Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The same procedure is used as for Compound I, using 2,4,6-triiodo-3-amino-benzoic acid as iodo starting material and ε-phthalimidocaproic acid chloride.
Source ID: ord-e7cdd99e255142c6979a18d36ef0fbcbConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The same procedure is used as for Compound I, using 2,4,6-triiodo-3-amino-benzoic acid as iodo starting material and ε-phthalimidocaproic acid chloride.
Source ID: ord-2a37f53de13449fd811d527aa2dbdfd5Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 6-phthalimidohexanoyl chloride (2 g.) in dry toluene was added to an ethereal solution of diazoethane at -78° C. and the mixture was allowed to warm to room temperature and stand for 15 hours. On standing a solid crystallized out of solution. The reaction mixture was filtered and the filtrate evaporated to dryness giving 1.43 g. of yellow-green oil. This oil was then dissolved in acetone and concentrated hydrochloric acid added until effervescence ceased. The resulting yellow-brown solution was then evaporated to dryness and azeotroped three times with toluene to give N-(7-chloro-6-oxooctyl)phthalimide (1.4 g.) which was used without further purification. crystallized out of solution The reaction mixture was filtered the filtrate evaporated to dryness giving 1.43 g The resulting yellow-brown solution was then evaporated to dryness azeotroped three times with toluene
Source ID: ord-a29164592f604bc480bf82c469987066Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 6-phthalimidohexanoyl chloride (2 g.) in dry toluene was added to an ethereal solution of diazoethane at -78° C. and the mixture was allowed to warm to room temperature and stand for 15 hours. On standing a solid crystallized out of solution. The reaction mixture was filtered and the filtrate evaporated to dryness giving 1.43 g. of yellow-green oil. This oil was then dissolved in acetone and concentrated hydrochloric acid added until effervescence ceased. The resulting yellow-brown solution was then evaporated to dryness and azeotroped three times with toluene to give N-(7-chloro-6-oxooctyl)phthalimide (1.4 g.) which was used without further purification. crystallized out of solution The reaction mixture was filtered the filtrate evaporated to dryness giving 1.43 g The resulting yellow-brown solution was then evaporated to dryness azeotroped three times with toluene
Source ID: ord-a5b1bb4e06e34b869b0d0326ce8b2fd5Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: A solution of 6-phthalimidohexanoyl chloride (2 g.) in dry toluene was added to an ethereal solution of diazoethane at -78° C. and the mixture was allowed to warm to room temperature and stand for 15 hours. On standing a solid crystallized out of solution. The reaction mixture was filtered and the filtrate evaporated to dryness giving 1.43 g. of yellow-green oil. This oil was then dissolved in acetone and concentrated hydrochloric acid added until effervescence ceased. The resulting yellow-brown solution was then evaporated to dryness and azeotroped three times with toluene to give N-(7-chloro-6-oxooctyl)phthalimide (1.4 g.) which was used without further purification. crystallized out of solution The reaction mixture was filtered the filtrate evaporated to dryness giving 1.43 g The resulting yellow-brown solution was then evaporated to dryness azeotroped three times with toluene
Source ID: ord-a5b1bb4e06e34b869b0d0326ce8b2fd5Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b5b5629ec56f43a387e66a22594c5b3fConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: The same procedure is used as for Compound I, using 2,4,6-triiodo-3-amino-benzoic acid as iodo starting marterial and ε-phthalimidocaproic acid chloride.
Source ID: ord-757ded56c3264e91905eb10f6c3901b8PubChem References
These sources are listed in the compound's public database record.
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