No renderable structure data available
C=CS(=O)(=O)NC1=CC=CC=C1Chemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | N-phenylethenesulfonamide |
|---|---|
| IUPAC Name | — |
| CAS Number | 3192-10-7 |
| Database ID | 12322399 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
N-phenylethenesulfonamide (CAS 3192-10-7) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 12322399
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-cb329a7951c444a5badc63764871e9c6Conditions: temp:85.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of phenyl(vinylsulfonyl)amine (141 mg, 0.77 mmol) and DIEA (0.47 mL, 4.9 mmol) in EtOH (7.5 mL) was added (2R)-1-(2-methylbenzothiazol-5-yloxy)-3-piperazin-1-ylpropan-2-ol (470 mg, 1.5 mmol, crude). The solution was heated for 2 hours at 85° C. on a J-Kem™ block. Upon cooling, the reaction mixture was concentrated to an oil and purified via flash column chromatography (4:1 EtOAc/MeOH) to afford [(2-{4-[(2R)-2-hydroxy-3-(2-methylbenzothiazol-5-yloxy)propyl]piperazinyl}ethyl)sulfonyl]phenylamine. Upon cooling the reaction mixture was concentrated to an oil purified via flash column chromatography (4:1 EtOAc/MeOH)
Source ID: ord-e71caed462a34f4faaa46d68df282de0Conditions: temp:85.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of phenyl(vinylsulfonyl)amine (141 mg, 0.77 mmol) and DIEA (0.47 mL, 4.9 mmol) in EtOH (7.5 mL) was added (2R)-1-(2-methylbenzothiazol-5-yloxy)-3-piperazin-1-ylpropan-2-ol (470 mg, 1.5 mmol, crude). The solution was heated for 2 hours at 85° C. on a J-Kem™ block. Upon cooling, the reaction mixture was concentrated to an oil and purified via flash column chromatography (4:1 EtOAc/MeOH) to afford [(2-{4-[(2R)-2-hydroxy-3-(2-methylbenzothiazol-5-yloxy)propyl]piperazinyl}ethyl)sulfonyl]phenylamine. Upon cooling the reaction mixture was concentrated to an oil purified via flash column chromatography (4:1 EtOAc/MeOH)
Source ID: ord-e71caed462a34f4faaa46d68df282de0Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Aniline (0.98 mL, 10.7 mmol) and Et3N (1.8 mL, 12.9 mmol) in toluene (25 mL) were treated with 2-chloro-1-ethanesulfonylchloride (1.1 mL, 10.5 mmol). The exothermic reaction was stirred for 14 hours at room temperature. After stirring, the solution was diluted with EtOAc and washed with HCl (˜10% aq. soln.). The organic layer concentrated and purified via flash column chromatography (4:1 hexane/EtOAc) to afford two lots of phenyl(vinylsulfonyl)amine. The exothermic reaction After stirring washed with HCl (˜10% aq. soln.) The organic layer concentrated purified via flash column chromatography (4:1 hexane/EtOAc)
Source ID: ord-67e8cb5e915a4fa9a119b8f925cd448eConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Aniline (0.98 mL, 10.7 mmol) and Et3N (1.8 mL, 12.9 mmol) in toluene (25 mL) were treated with 2-chloro-1-ethanesulfonylchloride (1.1 mL, 10.5 mmol). The exothermic reaction was stirred for 14 hours at room temperature. After stirring, the solution was diluted with EtOAc and washed with HCl (˜10% aq. soln.). The organic layer concentrated and purified via flash column chromatography (4:1 hexane/EtOAc) to afford two lots of phenyl(vinylsulfonyl)amine. The exothermic reaction After stirring washed with HCl (˜10% aq. soln.) The organic layer concentrated purified via flash column chromatography (4:1 hexane/EtOAc)
Source ID: ord-67e8cb5e915a4fa9a119b8f925cd448eConditions: temp:85.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of phenyl(vinylsulfonyl)amine (141 mg, 0.77 mmol) and DIEA (0.47 mL, 4.9 mmol) in EtOH (7.5 mL) was added (2R)-1-(2-methylbenzothiazol-5-yloxy)-3-piperazin-1-ylpropan-2-ol (470 mg, 1.5 mmol, crude). The solution was heated for 2 hours at 85° C. on a J-Kem™ block. Upon cooling, the reaction mixture was concentrated to an oil and purified via flash column chromatography (4:1 EtOAc/MeOH) to afford [(2-{4-[(2R)-2-hydroxy-3-(2-methylbenzothiazol-5-yloxy)propyl]piperazinyl}ethyl)sulfonyl]phenylamine. Upon cooling the reaction mixture was concentrated to an oil purified via flash column chromatography (4:1 EtOAc/MeOH)
Source ID: ord-59da7c17812943aa921c05e1ebe0d25dConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Aniline (0.98 mL, 10.7 mmol) and Et3N (1.8 mL, 12.9 mmol) in toluene (25 mL) were treated with 2-chloro-1-ethanesulfonylchloride (1.1 mL, 10.5 mmol). The exothermic reaction was stirred for 14 hours at room temperature. After stirring, the solution was diluted with EtOAc and washed with HCl (˜10% aq. soln.). The organic layer concentrated and purified via flash column chromatography (4:1 hexane/EtOAc) to afford two lots of phenyl(vinylsulfonyl)amine. The exothermic reaction After stirring washed with HCl (˜10% aq. soln.) The organic layer concentrated purified via flash column chromatography (4:1 hexane/EtOAc)
Source ID: ord-2e0d6debf4b047bc91d5fe645326e8f8Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Aniline (0.98 mL, 10.7 mmol) and Et3N (1.8 mL, 12.9 mmol) in toluene (25 mL) were treated with 2-chloro-1-ethanesulfonylchloride (1.1 mL, 10.5 mmol). The exothermic reaction was stirred for 14 hours at room temperature. After stirring, the solution was diluted with EtOAc and washed with HCl (˜10% aq. soln.). The organic layer concentrated and purified via flash column chromatography (4:1 hexane/EtOAc) to afford two lots of phenyl(vinylsulfonyl)amine. The exothermic reaction After stirring washed with HCl (˜10% aq. soln.) The organic layer concentrated purified via flash column chromatography (4:1 hexane/EtOAc)
Source ID: ord-2e0d6debf4b047bc91d5fe645326e8f8Conditions: temp:85.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of phenyl(vinylsulfonyl)amine (141 mg, 0.77 mmol) and DIEA (0.47 mL, 4.9 mmol) in EtOH (7.5 mL) was added (2R)-1-(2-methylbenzothiazol-5-yloxy)-3-piperazin-1-ylpropan-2-ol (470 mg, 1.5 mmol, crude). The solution was heated for 2 hours at 85° C. on a J-Kem™ block. Upon cooling, the reaction mixture was concentrated to an oil and purified via flash column chromatography (4:1 EtOAc/MeOH) to afford [(2-{4-[(2R)-2-hydroxy-3-(2-methylbenzothiazol-5-yloxy)propyl]piperazinyl}ethyl)sulfonyl]phenylamine. Upon cooling the reaction mixture was concentrated to an oil purified via flash column chromatography (4:1 EtOAc/MeOH)
Source ID: ord-e71caed462a34f4faaa46d68df282de0Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Aniline (0.98 mL, 10.7 mmol) and Et3N (1.8 mL, 12.9 mmol) in toluene (25 mL) were treated with 2-chloro-1-ethanesulfonylchloride (1.1 mL, 10.5 mmol). The exothermic reaction was stirred for 14 hours at room temperature. After stirring, the solution was diluted with EtOAc and washed with HCl (˜10% aq. soln.). The organic layer concentrated and purified via flash column chromatography (4:1 hexane/EtOAc) to afford two lots of phenyl(vinylsulfonyl)amine. The exothermic reaction After stirring washed with HCl (˜10% aq. soln.) The organic layer concentrated purified via flash column chromatography (4:1 hexane/EtOAc)
Source ID: ord-67e8cb5e915a4fa9a119b8f925cd448eConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-cb329a7951c444a5badc63764871e9c6Conditions: temp:85.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of phenyl(vinylsulfonyl)amine (141 mg, 0.77 mmol) and DIEA (0.47 mL, 4.9 mmol) in EtOH (7.5 mL) was added (2R)-1-(2-methylbenzothiazol-5-yloxy)-3-piperazin-1-ylpropan-2-ol (470 mg, 1.5 mmol, crude). The solution was heated for 2 hours at 85° C. on a J-Kem™ block. Upon cooling, the reaction mixture was concentrated to an oil and purified via flash column chromatography (4:1 EtOAc/MeOH) to afford [(2-{4-[(2R)-2-hydroxy-3-(2-methylbenzothiazol-5-yloxy)propyl]piperazinyl}ethyl)sulfonyl]phenylamine. Upon cooling the reaction mixture was concentrated to an oil purified via flash column chromatography (4:1 EtOAc/MeOH)
Source ID: ord-59da7c17812943aa921c05e1ebe0d25dPubChem References
These sources are listed in the compound's public database record.
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