propan-2-ylsulfanylbenzene

Conditions: temp:0.00; pressure:0.00; stir:

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In a round bottom flask was placed methylene chloride (70 mL) and aluminum trichloride (6.09 g, 45.65 mmol) and it was cooled to 0° C. in an ice bath. To this was then added dropwise chloro-oxo-acetic acid ethyl ester (3.98 mL, 35.79 mmol) keeping the temperature of the solution below 5° C. and it was then stirred for 30 min at 0° C. After this time a solution of isopropylsulfanyl-benzene (5.00 g, 32.84 mmol) in methylene chloride (5 mL) was added dropwise while keeping the temperature of the solution below 5° C. The ice bath was then removed and the reaction allowed to warm up to 25° C. and stirred for 3 h. The reaction was then cooled back down to 0° C. in an ice bath and added dropwise ice water (20 mL) keeping the temperature of the solution below 20° C. It was then stirred for 15 min and then transferred to a separatory funnel and separated. The organic phase was then washed with water (2×25 mL), saturated aqueous sodium bicarbonate solution (2×25 mL) and water (25 mL) and then dried over magnesium sulfate, filtered and concentrated in vacuo to afford (4-isopropylsulfanyl-phenyl)-oxo-acetic acid ethyl ester (5.85 g, 71%) as a yellow oil and used without further purification. In a round bottom flask was placed the temperature of the solution below 5° C. and it the temperature of the solution below 5° C The ice bath was then removed to warm up to 25° C. stirred for 3 h The reaction was then cooled back down to 0° C. in an ice bath added dropwise ice water (20 mL) the temperature of the solution below 20° C It was then stirred for 15 min transferred to a separatory funnel separated The organic phase was then washed with water (2×25 mL), saturated aqueous sodium bicarbonate solution (2×25 mL) and water (25 mL) dried over magnesium sulfate filtered concentrated in vacuo

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In a round bottom flask was placed methylene chloride (70 mL) and aluminum trichloride (6.09 g, 45.65 mmol) and it was cooled to 0° C. in an ice bath. To this was then added dropwise chloro-oxo-acetic acid ethyl ester (3.98 mL, 35.79 mmol) keeping the temperature of the solution below 5° C. and it was then stirred for 30 min at 0° C. After this time a solution of isopropylsulfanyl-benzene (5.00 g, 32.84 mmol) in methylene chloride (5 mL) was added dropwise while keeping the temperature of the solution below 5° C. The ice bath was then removed and the reaction allowed to warm up to 25° C. and stirred for 3 h. The reaction was then cooled back down to 0° C. in an ice bath and added dropwise ice water (20 mL) keeping the temperature of the solution below 20° C. It was then stirred for 15 min and then transferred to a separatory funnel and separated. The organic phase was then washed with water (2×25 mL), saturated aqueous sodium bicarbonate solution (2×25 mL) and water (25 mL) and then dried over magnesium sulfate, filtered and concentrated in vacuo to afford (4-isopropylsulfanyl-phenyl)-oxo-acetic acid ethyl ester (5.85 g, 71%) as a yellow oil and used without further purification. In a round bottom flask was placed the temperature of the solution below 5° C. and it the temperature of the solution below 5° C The ice bath was then removed to warm up to 25° C. stirred for 3 h The reaction was then cooled back down to 0° C. in an ice bath added dropwise ice water (20 mL) the temperature of the solution below 20° C It was then stirred for 15 min transferred to a separatory funnel separated The organic phase was then washed with water (2×25 mL), saturated aqueous sodium bicarbonate solution (2×25 mL) and water (25 mL) dried over magnesium sulfate filtered concentrated in vacuo

Conditions: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In a round bottom flask was placed methylene chloride (70 mL) and aluminum trichloride (6.09 g, 45.65 mmol) and it was cooled to 0° C. in an ice bath. To this was then added dropwise chloro-oxo-acetic acid ethyl ester (3.98 mL, 35.79 mmol) keeping the temperature of the solution below 5° C. and it was then stirred for 30 min at 0° C. After this time a solution of isopropylsulfanyl-benzene (5.00 g, 32.84 mmol) in methylene chloride (5 mL) was added dropwise while keeping the temperature of the solution below 5° C. The ice bath was then removed and the reaction allowed to warm up to 25° C. and stirred for 3 h. The reaction was then cooled back down to 0° C. in an ice bath and added dropwise ice water (20 mL) keeping the temperature of the solution below 20° C. It was then stirred for 15 min and then transferred to a separatory funnel and separated. The organic phase was then washed with water (2×25 mL), saturated aqueous sodium bicarbonate solution (2×25 mL) and water (25 mL) and then dried over magnesium sulfate, filtered and concentrated in vacuo to afford (4-isopropylsulfanyl-phenyl)-oxo-acetic acid ethyl ester (5.85 g, 71%) as a yellow oil and used without further purification. In a round bottom flask was placed the temperature of the solution below 5° C. and it the temperature of the solution below 5° C The ice bath was then removed to warm up to 25° C. stirred for 3 h The reaction was then cooled back down to 0° C. in an ice bath added dropwise ice water (20 mL) the temperature of the solution below 20° C It was then stirred for 15 min transferred to a separatory funnel separated The organic phase was then washed with water (2×25 mL), saturated aqueous sodium bicarbonate solution (2×25 mL) and water (25 mL) dried over magnesium sulfate filtered concentrated in vacuo