6-methyl-1,3-diazinane-2,4-dione

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In the manner described in IV above, 16.9 gm (0.13 mol) of 6-methyl-5,6-dihydrouracil were reacted with ketene in boiling ethyl acetate in the presence of sodium acetate. The product was recrystallized from a mixture of benzine (b.p. 70° C. to 95° C.) and isopropanol in the volume ratio of 1:1. The melting point was 84° C. to 86° C., and the elementary analysis resulted in the following values: The product was recrystallized from a mixture of benzine (b.p. 70° C. to 95° C.) and isopropanol in the volume ratio of 1:1 The melting point was 84° C. to 86° C., and the elementary analysis resulted in the following values

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In the manner described in IV above, 16.9 gm (0.13 mol) of 6-methyl-5,6-dihydrouracil were reacted with ketene in boiling ethyl acetate in the presence of sodium acetate. The product was recrystallized from a mixture of benzine (b.p. 70° C. to 95° C.) and isopropanol in the volume ratio of 1:1. The melting point was 84° C. to 86° C., and the elementary analysis resulted in the following values: The product was recrystallized from a mixture of benzine (b.p. 70° C. to 95° C.) and isopropanol in the volume ratio of 1:1 The melting point was 84° C. to 86° C., and the elementary analysis resulted in the following values

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: In the manner described above, 65 gm (0.5 mol) of 6-methyl-5,6-dihydrouracil were reacted with 8 mols of acetic acid anhydride in the presence of 2 ml of H2SO4. The product recrystallized from isopropanol had a melting point of 107° C to 109° C and the following analysis values: The product recrystallized from isopropanol

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: 6-Methyl-3-(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)dihydropyrimidine-2,4(1H,3H)-dione was prepared as for Example 10 from 6-methyldihydropyrimidine-2,4(1H,3H)-dione and the bromide from Example 7. After aqueous work-up and silica gel chromatography, the title compound was obtained.