1-chloropiperidine

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Under agitation, a solution of 12 g. of N-chloropiperidine in 15 ml. of concentrated sulfuric acid is added dropwise within 10 minutes to a mixture of 24.2 g. of 2-methyl-2-(4-phenylphenoxy)-propanol (obtainable from 4-hydroxy-diphenyl and 2-bromo-2-methylpropanol), 7 g. of iron(II) sulfate heptahydrate, 8 ml. of concentrated sulfuric acid, and 3 ml. of water. The mixture is agitated for 15 minutes at 20°, then poured on ice water, washed with ether, made alkaline with sodium hydroxide solution, and extracted with chloroform. From the extract, after evaporation, one obtains 2-methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propanol, m.p. 158°-160°. poured on ice water washed with ether extracted with chloroform From the extract, after evaporation, one

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Under agitation, a solution of 12 g. of N-chloropiperidine in 15 ml. of concentrated sulfuric acid is added dropwise within 10 minutes to a mixture of 24.2 g. of 2-methyl-2-(4-phenylphenoxy)-propanol (obtainable from 4-hydroxy-diphenyl and 2-bromo-2-methylpropanol), 7 g. of iron(II) sulfate heptahydrate, 8 ml. of concentrated sulfuric acid, and 3 ml. of water. The mixture is agitated for 15 minutes at 20°, then poured on ice water, washed with ether, made alkaline with sodium hydroxide solution, and extracted with chloroform. From the extract, after evaporation, one obtains 2-methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propanol, m.p. 158°-160°. poured on ice water washed with ether extracted with chloroform From the extract, after evaporation, one

Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

Procedure: Under agitation, a solution of 12 g. of N-chloropiperidine in 15 ml. of concentrated sulfuric acid is added dropwise within 10 minutes to a mixture of 24.2 g. of 2-methyl-2-(4-phenylphenoxy)-propanol (obtainable from 4-hydroxy-diphenyl and 2-bromo-2-methylpropanol), 7 g. of iron(II) sulfate heptahydrate, 8 ml. of concentrated sulfuric acid, and 3 ml. of water. The mixture is agitated for 15 minutes at 20°, then poured on ice water, washed with ether, made alkaline with sodium hydroxide solution, and extracted with chloroform. From the extract, after evaporation, one obtains 2-methyl-2-[4-(4-piperidinophenyl)-phenoxy]-propanol, m.p. 158°-160°. poured on ice water washed with ether extracted with chloroform From the extract, after evaporation, one