No renderable structure data available
CN1CC2=CC=CC=C2C(C1=O)NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | 4-amino-2-methyl-1,4-dihydroisoquinolin-3-one |
|---|---|
| IUPAC Name | — |
| CAS Number | 209983-88-0 |
| Database ID | 22312334 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
4-amino-2-methyl-1,4-dihydroisoquinolin-3-one (CAS 209983-88-0) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 22312334
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-ab9c429a0ad441718410c9ac6c8e6185Conditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step D—Removal of the Methoxyoxycarbonyl Group (MOC): To the 4-methoxycarbonylamino-1,2,3,4-tetrahydroisoquinoline-3-one (3.4 mmoles) in 30 ML of acetonitrile was added 2 mole equivalents of trimethylsilyliodide (TMSI). The reaction mixture was heated to 50-80° C. for 3 hrs and then cooled and poured into a separatory funnel. The reaction mixture was diluted with ethyl acetate and washed with 1 molar K2CO3 and then with 5% NaHSO3. The organic layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure to give the 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one derivative. Typical yields range from 50-87%. cooled poured into a separatory funnel washed with 1 molar K2CO3 The organic layer was dried over Na2SO4 filtered The solvent was removed under reduced pressure
Source ID: ord-4d1cd93b61e94170b10daebff9bea18bConditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step D—Removal of the Methoxyoxycarbonyl Group (MOC): To the 4-methoxycarbonylamino-1,2,3,4-tetrahydroisoquinoline-3-one (3.4 mmoles) in 30 mL of acetonitrile was added 2 mole equivalents of trimethylsilyliodide (TMSI). The reaction mixture was heated to 50-80° C. for 3 hrs and then cooled and poured into a seperatory funnel. The reaction mixture was diluted with ethyl acetate and washed with 1 molar K2CO3 and then with 5% NaHSO3. The organic layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure to give the 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one derivative. Typical yields range from 50-87%. cooled poured into a seperatory funnel washed with 1 molar K2CO3 The organic layer was dried over Na2SO4 filtered The solvent was removed under reduced pressure
Source ID: ord-79c385c681ce400b828d3c084f2974efConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Following General Procedure D above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 4-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline-3-one (General Procedure 5-D), the title compound was prepared as a solid having a melting point of 174-175° C.
Source ID: ord-2b6de1378ebf454f9b8c6ef916751a44Conditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step D—Removal of the Methoxyoxycarbonyl Group (MOC): To the 4-methoxycarbonylamino-1,2,3,4-tetrahydroisoquinoline-3-one (3.4 mmoles) in 30 mL of acetonitrile was added 2 mole equivalents of trimethylsilyliodide (TMSI). The reaction mixture was heated to 50-80° C. for 3 hrs and then cooled and poured into a seperatory funnel. The reaction mixture was diluted with ethyl acetate and washed with 1 molar K2CO3 and then with 5% NaHSO3. The organic layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure to give the 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one derivative. Typical yields range from 50-87%. cooled poured into a seperatory funnel washed with 1 molar K2CO3 The organic layer was dried over Na2SO4 filtered The solvent was removed under reduced pressure
Source ID: ord-2678e0c208844193ad5310a577a9d0f5Conditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step D—Removal of the Methoxyoxycarbonyl Group (MOC): To the 4-methoxycarbonylamino-1,2,3,4-tetrahydroisoquinoline-3-one (3.4 mmoles) in 30 mL of acetonitrile was added 2 mole equivalents of trimethylsilyliodide (TMSI). The reaction mixture was heated to 50-80° C. for 3 hrs and then cooled and poured into a seperatory funnel. The reaction mixture was diluted with ethyl acetate and washed with 1 molar K2CO3 and then with 5% NaHSO3. The organic layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure to give the 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one derivative. Typical yields range from 50-87%. cooled poured into a seperatory funnel washed with 1 molar K2CO3 The organic layer was dried over Na2SO4 filtered The solvent was removed under reduced pressure
Source ID: ord-ac07dd396dd04e72976c7a13151e70c3Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step D—Removal of the Methoxyoxycarbonyl Group (MOC): To the 4-methoxycarbonylamino-1,2,3,4-tetrahydroisoquinoline-3-one (3.4 mmoles) in 30 mL of acetonitrile was added 2 mole equivalents of trimethylsilyliodide (TMSI). The reaction mixture was heated to 50–80° C. for 3 hrs and then cooled and poured into a seperatory funnel. The reaction mixture was diluted with ethyl acetate and washed with 1 molar K2CO3 and then with 5% NaHSO3. The organic layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure to give the 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one derivative. Typical yields range from 50–87%. The reaction mixture was heated to 50–80° C. for 3 hrs cooled poured into a seperatory funnel washed with 1 molar K2CO3 The organic layer was dried over Na2SO4 filtered The solvent was removed under reduced pressure
Source ID: ord-92281e3b17f8412faa90cb15593141c9Conditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step D—Removal of the Methoxyoxycarbonyl Group (MOC): To the 4-methoxycarbonylamino-1,2,3,4-tetrahydroisoquinoline-3-one (3.4 mmoles) in 30 mL of acetonitrile was added 2 mole equivalents of trimethylsilyliodide (TMSI). The reaction mixture was heated to 50-80° C. for 3 hrs and then cooled and poured into a seperatory funnel. The reaction mixture was diluted with ethyl acetate and washed with 1 molar K2CO3 and then with 5% NaHSO3. The organic layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure to give the 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one derivative. Typical yields range from 50-87%. cooled poured into a seperatory funnel washed with 1 molar K2CO3 The organic layer was dried over Na2SO4 filtered The solvent was removed under reduced pressure
Source ID: ord-451c3567786a4558b7322ff08532a196Conditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step D—Removal of the Methoxyoxvcarbonyl Group (MOC): To the 4-methoxycarbonylamino-1,2,3,4-tetrahydroisoquinoline-3-one (3,4 mmoles) in 30 mL of acetonitrile was added 2 mole equivalents of trimethylsilyliodide (TMSI). The reaction mixture was heated to 50-80° C. for 3 hrs and then cooled and poured into a seperatory funnel. The reaction mixture was diluted with ethyl acetate and washed with 1 molar K2CO3 and then with 5% NaHSO3. The organic layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure to give the 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one derivative. Typical yields range from 50-87%. cooled poured into a seperatory funnel washed with 1 molar K2CO3 The organic layer was dried over Na2SO4 filtered The solvent was removed under reduced pressure
Source ID: ord-96cc6c572bb4433ab28fe436221f35a6Conditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step D—Removal of the Methoxyoxvcarbonyl Group (MOC): To the 4-methoxycarbonylamino-1,2,3,4-tetrahydroisoquinoline-3-one (3,4 mmoles) in 30 mL of acetonitrile was added 2 mole equivalents of trimethylsilyliodide (TMSI). The reaction mixture was heated to 50-80° C. for 3 hrs and then cooled and poured into a seperatory funnel. The reaction mixture was diluted with ethyl acetate and washed with 1 molar K2CO3 and then with 5% NaHSO3. The organic layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure to give the 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one derivative. Typical yields range from 50-87%. cooled poured into a seperatory funnel washed with 1 molar K2CO3 The organic layer was dried over Na2SO4 filtered The solvent was removed under reduced pressure
Source ID: ord-96cc6c572bb4433ab28fe436221f35a6Conditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step D—Removal of the Methoxyoxycarbonyl Group (MOC): To the 4-methoxycarbonylamino-1,2,3,4-tetrahydroisoquinoline-3-one (3.4 mmoles) in 30 ML of acetonitrile was added 2 mole equivalents of trimethylsilyliodide (TMSI). The reaction mixture was heated to 50-80° C. for 3 hrs and then cooled and poured into a separatory funnel. The reaction mixture was diluted with ethyl acetate and washed with 1 molar K2CO3 and then with 5% NaHSO3. The organic layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure to give the 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one derivative. Typical yields range from 50-87%. cooled poured into a separatory funnel washed with 1 molar K2CO3 The organic layer was dried over Na2SO4 filtered The solvent was removed under reduced pressure
Source ID: ord-4d1cd93b61e94170b10daebff9bea18bConditions: temp:65.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: Step D—Removal of the Methoxyoxycarbonyl Group (MOC): To the 4-methoxycarbonylamino-1,2,3,4-tetrahydroisoquinoline-3-one (3.4 mmoles) in 30 mL of acetonitrile was added 2 mole equivalents of trimethylsilyliodide (TMSI). The reaction mixture was heated to 50-80° C. for 3 hrs and then cooled and poured into a seperatory funnel. The reaction mixture was diluted with ethyl acetate and washed with 1 molar K2CO3 and then with 5% NaHSO3. The organic layer was dried over Na2SO4 and filtered. The solvent was removed under reduced pressure to give the 4-amino-1,2,3,4-tetrahydroisoquinoline-3-one derivative. Typical yields range from 50-87%. cooled poured into a seperatory funnel washed with 1 molar K2CO3 The organic layer was dried over Na2SO4 filtered The solvent was removed under reduced pressure
Source ID: ord-79c385c681ce400b828d3c084f2974efPubChem References
These sources are listed in the compound's public database record.
Request a Quote
Send the required specification, quantity, destination and intended use. The CATO team will review availability and respond.