No renderable structure data available
COC1=CC(=C(C=C1C(=O)OC)Cl)NChemical Intermediate
Structures, identifiers and computed properties have been matched to the database record by CAS.
| Intermediates | Methyl 4-amino-5-chloro-2-methoxybenzoate |
|---|---|
| IUPAC Name | — |
| CAS Number | 20896-27-9 |
| Database ID | 700493 |
| Molecular Formula | — |
| Molecular Weight | — |
Product Information
Methyl 4-amino-5-chloro-2-methoxybenzoate (CAS 20896-27-9) product identity, structure identifiers and related reaction data for chemical intermediate research and sourcing review.
Potential Applications
For professional research and industrial use only
Database ID 700493
Safety Notice
For professional research and industrial use only. Review the supplier safety data sheet before handling.
Synthesis data
12 reactions · 12 references
Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-474976d998ad443a89eeb42c72403696Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b32e7e54a63e46fb99a52ae2e936c63eConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-a889f3b1f5c44004ae75c31d934d034bConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-7ae465e6d88642398da8a1684fc4cd45Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-6ee6b4d56303492c88f9be294b9f60d6Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a 1-liter three-necked round-bottom flask equipped with overhead stirrer, temperature control and addition funnel was added methyl 4-amino-5-chloro-2-methoxybenzoate (44.2 g, 200 mmol), dichloromethane (500 mL) and diisopropylethylamine (104.5 mL, 600 mmol). The resulting mixture was stirred at room temperature until the ingredients dissolved and then the mixture was cooled to 0° C. Acryloyl chloride (16.25 mL, 200 mmol) was then added dropwise while maintaining the internal reaction mixture temperature below 10° C. The total time for addition was about 30 min. The reaction mixture was then slowly warmed from 0° C. to room temperature over a period of about 2 hours. Aqueous saturated sodium bicarbonate solution (200 mL) and dichloromethane (200 mL) were then added and this mixture was stirred for 15 min. and then the layers were separated. The dichloromethane layer was washed with 1 M hydrochloric acid (200 mL) and then concentrated under reduced pressure to about one-third its original volume resulting in a thick slurry. The slurry was filtered and the filter cake was washed with dichloromethane (100 mL) and dried to provide the title compound as an off-white solid (36 g, 67% yield, >98% purity by HPLC). To a 1-liter three-necked round-bottom flask equipped with overhead stirrer temperature control and addition funnel dissolved the mixture was cooled to 0° C while maintaining the internal reaction mixture temperature below 10° C The total time for addition The reaction mixture was then slowly warmed from 0° C. to room temperature over a period of about 2 hours this mixture was stirred for 15 min. the layers were separated The dichloromethane layer was washed with 1 M hydrochloric acid (200 mL) concentrated under reduced pressure to about one-third its original volume resulting in a thick slurry The slurry was filtered the filter cake was washed with dichloromethane (100 mL) dried
Source ID: ord-1ceb5bdbb1d44a5bac33cae815091e3cConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-amino-5-chloro-2-methoxybenzoic acid (1.008 g, 5.0 mmol) in a mixture of toluene (9 mL) and methanol (1 mL) at 0° C. was added (trimethylsilyl)diazomethane (2.0 M in hexane, 3.0 mL, 6.0 mmol) dropwise. The reaction mixture was then warmed to room temperature and stirred for 16 h. Excess (trimethylsilyl)diazomethane was quenched by adding acetic acid until the bright yellow color of the reaction mixture disappeared. The mixture was then concentrated in vacuo to give the title compound as an off-white solid, which was used without further purification. Excess (trimethylsilyl)diazomethane was quenched by adding acetic acid until the bright yellow color of the reaction mixture The mixture was then concentrated in vacuo
Source ID: ord-9456091775ba44c8bed1ceebb8f05febConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a 1-liter three-necked round-bottom flask equipped with overhead stirrer, temperature control and addition funnel was added methyl 4-amino-5-chloro-2-methoxybenzoate (44.2 g, 200 mmol), dichloromethane (500 mL) and diisopropylethylamine (104.5 mL, 600 mmol). The resulting mixture was stirred at room temperature until the ingredients dissolved and then the mixture was cooled to 0° C. Acryloyl chloride (16.25 mL, 200 mmol) was then added dropwise while maintaining the internal reaction mixture temperature below 10° C. The total time for addition was about 30 min. The reaction mixture was then slowly warmed from 0° C. to room temperature over a period of about 2 hours. Aqueous saturated sodium bicarbonate solution (200 mL) and dichloromethane (200 mL) were then added and this mixture was stirred for 15 min. and then the layers were separated. The dichloromethane layer was washed with 1 M hydrochloric acid (200 mL) and then concentrated under reduced pressure to about one-third its original volume resulting in a thick slurry. The slurry was filtered and the filter cake was washed with dichloromethane (100 mL) and dried to provide the title compound as an off-white solid (36 g, 67% yield, >98% purity by HPLC). To a 1-liter three-necked round-bottom flask equipped with overhead stirrer temperature control and addition funnel dissolved the mixture was cooled to 0° C while maintaining the internal reaction mixture temperature below 10° C The total time for addition The reaction mixture was then slowly warmed from 0° C. to room temperature over a period of about 2 hours this mixture was stirred for 15 min. the layers were separated The dichloromethane layer was washed with 1 M hydrochloric acid (200 mL) concentrated under reduced pressure to about one-third its original volume resulting in a thick slurry The slurry was filtered the filter cake was washed with dichloromethane (100 mL) dried
Source ID: ord-89574fdd6e744409a0eaf5f0e5795212Conditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-amino-5-chloro-2-methoxybenzoic acid (1.008 g, 5.0 mmol) in a mixture of toluene (9 mL) and methanol (1 mL) at 0° C. was added (trimethylsilyl)diazomethane (2.0 M in hexane, 3.0 mL, 6.0 mmol) dropwise. The reaction mixture was then warmed to room temperature and stirred for 16 h. Excess (trimethylsilyl)diazomethane was quenched by adding acetic acid until the bright yellow color of the reaction mixture disappeared. The mixture was then concentrated in vacuo to give the title compound as an off-white solid, which was used without further purification. Excess (trimethylsilyl)diazomethane was quenched by adding acetic acid until the bright yellow color of the reaction mixture The mixture was then concentrated in vacuo
Source ID: ord-5bb34760073c43ca8f9742c14fb559aeConditions: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
Procedure: To a solution of 4-amino-5-chloro-2-methoxybenzoic acid (20.0 g, 99.2 mmol) in methanol (250 mL) was added thionyl chloride (7.2 mL, 99.2 mmol). The reaction was refluxed for 16 h then concentrated in vacuo. Purification by silica gel chromatography (0-90% ethyl acetate/hexanes) provided methyl 4-amino-5-chloro-2-methoxybenzoate (21.3 g, quantitative yield). LC/MS m/z 216.3 [M+H]+. The reaction was refluxed for 16 h then concentrated in vacuo Purification by silica gel chromatography (0-90% ethyl acetate/hexanes)
Source ID: ord-c854b6fe5af44a9c93661e851951073bConditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-474976d998ad443a89eeb42c72403696Conditions: temp:0.00; pressure:0.00; stir:
Source ID: ord-b32e7e54a63e46fb99a52ae2e936c63ePubChem References
These sources are listed in the compound's public database record.
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